High impact information on Valerenic acid

• In addition, pretreatment with valerian extract or valerenic acid decreased the brainstem inhibitory effects produced by muscimol (both P < 0.05), suggesting that these compounds play an important role in the regulation of GABAergic activity [1].
• Seasonal variation of the essential oil, valerenic acid and derivatives, and velopotriates in Valeriana officinalis roots and rhizomes, and the selection of plants suitable for phytomedicines [2].
• Pharmacokinetics of valerenic acid after administration of valerian in healthy subjects [3].
• The area under the concentration time curve (AUC) as a measure of valerenic acid exposure was variable (4.80 +/- 2.96 microg/mL. h) and not correlated with subject's age or weight [3].
• A separation of valerenic acid and its hydroxy and acetoxy derivatives, three compounds characteristic for the species, was achieved using a 40 mM phosphate-borate buffer at pH 8.5, which contained 10% isopropanol as organic modifier [4].

Analytical, diagnostic and therapeutic context of Valerenic acid

• To investigate the variations of active compounds between species, varieties and individuals of Valeriana cultivated under the same environmental condition, the contents of valerenic acid derivatives and valepotriates in rhizomes and roots of different plant material were analysed by a HPLC method [5].

References