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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Valerian

  • The frequency of positive precipitin reactions to the antigen of Gram-negative bacterium Pantoea agglomerans was very high in valerian farmers (45.5 %) with 3-fold concentrated sera and significantly greater compared to the reference group (p < 0.001) [1].

Psychiatry related information on Valerian


High impact information on Valerian


Biological context of Valerian


Anatomical context of Valerian


Associations of Valerian with chemical compounds


Gene context of Valerian

  • Our results indicate that although a modest increase was observed in the alprazolam Cmax, typical doses of valerian are unlikely to produce clinically significant effects on the disposition of medications dependent on the CYP2D6 or CYP3A4 pathways of metabolism [17].
  • The objective of this study was to assess the influence of a valerian extract on the activity of the drug-metabolizing enzymes cytochrome P450 2D6 (CYP2D6) and 3A4 [17].
  • Valerian extracts from the products tested also exhibited a marked capacity to inhibit cytochrome P450 3A4-mediated metabolism and P-glycoprotein transport based upon the ATPase assay [18].
  • In this report, the binding of Ze91019, and the component valerian and hops extracts within, was tested on 14 subtypes of five classes of central receptors (dopamine, serotonin, melatonin, MCH and neuropeptide-Y) [19].
  • Neurological stamp. Valeriana officinalis (garden heliotrope) [20].

Analytical, diagnostic and therapeutic context of Valerian

  • Over-the-counter agents such as valerian and melatonin may be useful in alleviating mild, short-term insomnia, but further clinical trials are required to fully evaluate their safety and efficacy [21].
  • The essential oil content and the composition of subterranean parts of two valerian (Valeriana officinalis, L.) cultivars Select and Anthose, from certified commercial organic fields, were determined by hydrodistillation, followed by gas chromatography (GC) and GC/mass spectrometry analysis [22].
  • Concomitant administration of valerian extract and pentobarbital showed a synergistic effect on motor coordination and traction force in mice [23].
  • To investigate the variations of active compounds between species, varieties and individuals of Valeriana cultivated under the same environmental condition, the contents of valerenic acid derivatives and valepotriates in rhizomes and roots of different plant material were analysed by a HPLC method [24].


  1. Health effects of exposure to herb dust in valerian growing farmers. Skórska, C., Golec, M., Mackiewicz, B., Góra, A., Dutkiewicz, J. Annals of agricultural and environmental medicine : AAEM. (2005) [Pubmed]
  2. Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Morin, C.M., Koetter, U., Bastien, C., Ware, J.C., Wooten, V. Sleep. (2005) [Pubmed]
  3. Herbs and nutrients in the treatment of depression, anxiety, insomnia, migraine, and obesity. Brown, R.P., Gerbarg, P.L. Journal of psychiatric practice. (2001) [Pubmed]
  4. Dietary supplements used in the treatment of depression, anxiety, and sleep disorders. Cauffield, J.S., Forbes, H.J. Lippincott's primary care practice. (1999) [Pubmed]
  5. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Gurley, B.J., Gardner, S.F., Hubbard, M.A., Williams, D.K., Gentry, W.B., Khan, I.A., Shah, A. Clin. Pharmacol. Ther. (2005) [Pubmed]
  6. Complementary medicines in psychiatry: review of effectiveness and safety. Werneke, U., Turner, T., Priebe, S. The British journal of psychiatry : the journal of mental science. (2006) [Pubmed]
  7. Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects. Glass, J.R., Sproule, B.A., Herrmann, N., Streiner, D., Busto, U.E. Journal of clinical psychopharmacology. (2003) [Pubmed]
  8. Could valerian have been the first anticonvulsant? Eadie, M.J. Epilepsia (2004) [Pubmed]
  9. Seasonal variation of the essential oil, valerenic acid and derivatives, and velopotriates in Valeriana officinalis roots and rhizomes, and the selection of plants suitable for phytomedicines. Bos, R., Woerdenbag, H.J., van Putten, F.M., Hendriks, H., Scheffer, J.J. Planta Med. (1998) [Pubmed]
  10. The amount of GABA present in aqueous extracts of valerian is sufficient to account for [3H]GABA release in synaptosomes. Santos, M.S., Ferreira, F., Faro, C., Pires, E., Carvalho, A.P., Cunha, A.P., Macedo, T. Planta Med. (1994) [Pubmed]
  11. Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors. Schumacher, B., Scholle, S., Hölzl, J., Khudeir, N., Hess, S., Müller, C.E. J. Nat. Prod. (2002) [Pubmed]
  12. Ultrasound-assisted extraction of water-soluble polysaccharides from the roots of valerian (Valeriana officinalis L.). Hromádková, Z., Ebringerová, A., Valachovic, P. Ultrasonics sonochemistry. (2002) [Pubmed]
  13. In vitro study on the interaction of Valeriana officinalis L. extracts and their amino acids on GABAA receptor in rat brain. Cavadas, C., Araújo, I., Cotrim, M.D., Amaral, T., Cunha, A.P., Macedo, T., Ribeiro, C.F. Arzneimittel-Forschung. (1995) [Pubmed]
  14. Dietary supplements: how they are used and regulated. Hathcock, J. J. Nutr. (2001) [Pubmed]
  15. The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. Yuan, C.S., Mehendale, S., Xiao, Y., Aung, H.H., Xie, J.T., Ang-Lee, M.K. Anesth. Analg. (2004) [Pubmed]
  16. The fixed combination of valerian and hops (Ze91019) acts via a central adenosine mechanism. Schellenberg, R., Sauer, S., Abourashed, E.A., Koetter, U., Brattström, A. Planta Med. (2004) [Pubmed]
  17. Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers. Donovan, J.L., DeVane, C.L., Chavin, K.D., Wang, J.S., Gibson, B.B., Gefroh, H.A., Markowitz, J.S. Drug Metab. Dispos. (2004) [Pubmed]
  18. In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4. Lefebvre, T., Foster, B.C., Drouin, C.E., Krantis, A., Livesey, J.F., Jordan, S.A. Journal of pharmacy & pharmaceutical sciences [electronic resource] : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques. (2004) [Pubmed]
  19. In vitro binding experiments with a Valerian, hops and their fixed combination extract (Ze91019) to selected central nervous system receptors. Abourashed, E.A., Koetter, U., Brattström, A. Phytomedicine (2004) [Pubmed]
  20. Neurological stamp. Valeriana officinalis (garden heliotrope). Haas, L.F. J. Neurol. Neurosurg. Psychiatr. (1996) [Pubmed]
  21. Beyond benzodiazepines: alternative pharmacologic agents for the treatment of insomnia. Wagner, J., Wagner, M.L., Hening, W.A. The Annals of pharmacotherapy. (1998) [Pubmed]
  22. Essential oil of Valeriana officinalis L. cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation. Letchamo, W., Ward, W., Heard, B., Heard, D. J. Agric. Food Chem. (2004) [Pubmed]
  23. Neuropharmacological profile of hydroalcohol extract of Valeriana edulis ssp. procera roots in mice. Oliva, I., González-Trujano, M.E., Arrieta, J., Enciso-Rodríguez, R., Navarrete, A. Phytotherapy research : PTR. (2004) [Pubmed]
  24. Valerenic acid derivatives and valepotriates among individuals, varieties and species of Valeriana. Gao, X.Q., Björk, L. Fitoterapia (2000) [Pubmed]
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