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Chemical Compound Review

isopropanol     propan-2-ol

Synonyms: Alkolave, Avantine, Hartosol, Petrohol, Spectrar, ...
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Disease relevance of isopropanol


Psychiatry related information on isopropanol


High impact information on isopropanol


Chemical compound and disease context of isopropanol


Biological context of isopropanol


Anatomical context of isopropanol


Associations of isopropanol with other chemical compounds

  • Natural bond orbital (NBO) analysis of glucose and dihedral rotational equilibrium isotope effects in 2-propanol strongly imply a hyperconjugative mechanism for the isotope effects at H1 and H2 [30].
  • Ab initio calculations on 2-propanol with or without a hydrogen bonding partner, in steric collision with formaldehyde or methane, and on ethanol, cyclohexanol and 1-hydroxymethyl-tetrahydropyran are presented to clarify the magnitude of isotope effects possible in such interactions and the accompanying changes in free energy [31].
  • A T2-RNase treatment of poly(A) irradiated with 2-propanol gave the modified Ado-21:3'-P, while T2-RNase digestion of poly(A) irradiated with D-ribose led to the cyclic modified mononucleotides, in addition to the modified mononucleotides [32].
  • Addition of 2-propanol and benzamidine/HCl proved essential to obtain single crystals suitable for X-ray analysis [33].
  • Next, the optimization of the ESI-MS sheath liquid composition is conducted comparing methanol to isopropanol followed by the use of experimental design for analysis of spray chamber parameters [34].

Gene context of isopropanol

  • Furthermore, Kit receptors can be down-regulated by proteolytic cleavage induced by either activation of protein kinase C or by isopropyl alcohol [35].
  • A truncated variant of TPK1, the yeast cAMP-dependent protein kinase catalytic subunit, was overexpressed in an engineered strain of Saccharomyces cerevisiae, purified by liquid chromatography, and crystallized from solutions of 2-propanol and magnesium at alkaline pH [36].
  • Reversible activation of prophenoloxidase with 2-propanol in Drosophila melanogaster [37].
  • The MTCP-1 recombinant proteins display greater solubility, do not form disulfide linked dimers or oligomers, and elute at a lower isopropanol concentration than the corresponding TCL-1 proteins [38].
  • In addition, 2-propanol derived from the crystallization solution occupied the hydrophobic cavity, which is proposed to be a CO trapping site in rat HO-1 that suppresses product inhibition [39].

Analytical, diagnostic and therapeutic context of isopropanol

  • 5 seconds of skin cleansing of sites on the leg, arm, and abdomen with 70% isopropyl alcohol reduced bacterial counts by 82-91% [40].
  • Equivalent results are obtained by pulse radiolysis using isopropanol radical as the reducing agent [41].
  • Isopropanol precipitation removes PCR inhibitors from ancient bone extracts [42].
  • This review presents clinical, pharmacologic, and management data, contrasts important aspects in differential diagnosis, and suggests an appropriate approach to management of isopropyl alcohol intoxication [43].
  • We now report a rapid, simple isocratic HPLC procedure for the determination of CoQ10H2 and CoQ10 in plasma isopropanol extracts, and we used this method to investigate conditions by which the CoQ10H2/CoQ10 ratio can be reliably measured [44].


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  20. The elongation factor G carries a catalytic site for GTP hydrolysis, which is revealed by using 2-propanol in the absence of ribosomes. De Vendittis, E., Masullo, M., Bocchini, V. J. Biol. Chem. (1986) [Pubmed]
  21. Pseudomonas aeruginosa and Enterobacteriaceae bacteremia after biliary endoscopy: an outbreak investigation using DNA macrorestriction analysis. Struelens, M.J., Rost, F., Deplano, A., Maas, A., Schwam, V., Serruys, E., Cremer, M. Am. J. Med. (1993) [Pubmed]
  22. Iridium(0) nanocluster, acid-assisted catalysis of neat acetone hydrogenation at room temperature: exceptional activity, catalyst lifetime, and selectivity at complete conversion. Ozkar, S., Finke, R.G. J. Am. Chem. Soc. (2005) [Pubmed]
  23. Probing molecular structure at interfaces for comparison with bulk solution behavior: water/2-propanol mixtures monitored by vibrational sum frequency spectroscopy. Kataoka, S., Cremer, P.S. J. Am. Chem. Soc. (2006) [Pubmed]
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  28. Retinoid kinetics in eye tissues of VPP transgenic mice and their normal littermates. Qtaishat, N.M., Okajima, T.I., Li, S., Naash, M.I., Pepperberg, D.R. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
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  33. Crystallization of enzyme IIB of the cellobiose-specific phosphotransferase system of Escherichia coli. van Montfort, R.L., Pijning, T., Kalk, K.H., Schuurman-Wolters, G.K., Reizer, J., Saier, M.H., Robillard, G., Dijkstra, B.W. J. Mol. Biol. (1994) [Pubmed]
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  38. Purification and characterization of recombinant forms of TCL-1 and MTCP-1 proteins. Du Bois, G.C., Song, S.P., Kulikovskaya, I., Virgilio, L., Varnum, J., Germann, M.W., Croce, C.M. Protein Expr. Purif. (1998) [Pubmed]
  39. Crystal structure of heme oxygenase-1 from cyanobacterium Synechocystis sp. PCC 6803 in complex with heme. Sugishima, M., Migita, C.T., Zhang, X., Yoshida, T., Fukuyama, K. Eur. J. Biochem. (2004) [Pubmed]
  40. Is skin preparation necessary before insulin injection? Koivisto, V.A., Felig, P. Lancet (1978) [Pubmed]
  41. Direct measurements of intramolecular electron transfer rates between cytochrome c and cytochrome c peroxidase: effects of exothermicity and primary sequence on rate. Cheung, E., Taylor, K., Kornblatt, J.A., English, A.M., McLendon, G., Miller, J.R. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  42. Isopropanol precipitation removes PCR inhibitors from ancient bone extracts. Hänni, C., Brousseau, T., Laudet, V., Stehelin, D. Nucleic Acids Res. (1995) [Pubmed]
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