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Chemical Compound Review:

RI-331 (2S)-2-amino-5-hydroxy-4-oxo- pentanoic acid

Synonyms: AG-K-68475, H-899, AC1Q5QJM, LS-97526, CTK4I8166, ...

Yamaguchi, M. et al., Yamaki, H. et al., Yamaki, H. et al.

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Disease relevance of Norvaline, 5-hydroxy-4-oxo-

An antifungal amino acid antibiotic, (S)2-amino-4-oxo-5-hydroxypentanoic acid (RI-331) isolated from Streptomyces sp., inhibited the biosynthesis of protein to a greater extent than that of RNA or DNA in growing Saccharomyces cerevisiae cells [1].

High impact information on Norvaline, 5-hydroxy-4-oxo-

The mechanism of antifungal action of (S)-2-amino-4-oxo-5-hydroxypentanoic acid, RI-331: the inhibition of homoserine dehydrogenase in Saccharomyces cerevisiae [2].
It looks likely therefore that the inhibition of biosyntheses of some or all of these amino acids by RI-331 is primarily responsible for overall inhibition of protein biosynthesis in yeasts, ultimately leading to cytostasis [1].

Biological context of Norvaline, 5-hydroxy-4-oxo-

Mechanism of action of an antifungal antibiotic, RI-331, (S) 2-amino-4-oxo-5-hydroxypentanoic acid; kinetics of inactivation of homoserine dehydrogenase from Saccharomyces cerevisiae [3].

References

The mode of antifungal action of (S)2-amino-4-oxo-5-hydroxypentanoic acid, RI-331. Yamaguchi, M., Yamaki, H., Shinoda, T., Tago, Y., Suzuki, H., Nishimura, T., Yamaguchi, H. J. Antibiot. (1990) [Pubmed]
The mechanism of antifungal action of (S)-2-amino-4-oxo-5-hydroxypentanoic acid, RI-331: the inhibition of homoserine dehydrogenase in Saccharomyces cerevisiae. Yamaki, H., Yamaguchi, M., Imamura, H., Suzuki, H., Nishimura, T., Saito, H., Yamaguchi, H. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
Mechanism of action of an antifungal antibiotic, RI-331, (S) 2-amino-4-oxo-5-hydroxypentanoic acid; kinetics of inactivation of homoserine dehydrogenase from Saccharomyces cerevisiae. Yamaki, H., Yamaguchi, M., Tsuruo, T., Yamaguchi, H. J. Antibiot. (1992) [Pubmed]

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