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Gene Review

HOM6  -  homoserine dehydrogenase

Saccharomyces cerevisiae S288c

Synonyms: HDH, Homoserine dehydrogenase, J2132, YJR139C
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Disease relevance of HOM6


Psychiatry related information on HOM6

  • Moreover, in the case of the other strain, higher levels of enzymes required for sulfur metabolism (Cys4p, Hom6p, and Met22p) are observed, which could be related to the production of particular organoleptic compounds or to detoxification processes [3].

High impact information on HOM6


Chemical compound and disease context of HOM6


Biological context of HOM6


Associations of HOM6 with chemical compounds


Analytical, diagnostic and therapeutic context of HOM6


  1. Evolutionary relationships between yeast and bacterial homoserine dehydrogenases. Thomas, D., Barbey, R., Surdin-Kerjan, Y. FEBS Lett. (1993) [Pubmed]
  2. Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity. Jacques, S.L., Nieman, C., Bareich, D., Broadhead, G., Kinach, R., Honek, J.F., Wright, G.D. Biochim. Biophys. Acta (2001) [Pubmed]
  3. Transcriptomic and proteomic approach for understanding the molecular basis of adaptation of Saccharomyces cerevisiae to wine fermentation. Zuzuarregui, A., Monteoliva, L., Gil, C., del Olmo, M. Appl. Environ. Microbiol. (2006) [Pubmed]
  4. Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases. DeLaBarre, B., Thompson, P.R., Wright, G.D., Berghuis, A.M. Nat. Struct. Biol. (2000) [Pubmed]
  5. Transcriptional and biochemical regulation of a novel Arabidopsis thaliana bifunctional aspartate kinase-homoserine dehydrogenase gene isolated by functional complementation of a yeast hom6 mutant. Rognes, S.E., Dewaele, E., Aas, S.F., Jacobs, M., Frankard, V. Plant Mol. Biol. (2003) [Pubmed]
  6. Mechanism of action of an antifungal antibiotic, RI-331, (S) 2-amino-4-oxo-5-hydroxypentanoic acid; kinetics of inactivation of homoserine dehydrogenase from Saccharomyces cerevisiae. Yamaki, H., Yamaguchi, M., Tsuruo, T., Yamaguchi, H. J. Antibiot. (1992) [Pubmed]
  7. FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation. Arévalo-Rodríguez, M., Pan, X., Boeke, J.D., Heitman, J. Eukaryotic Cell (2004) [Pubmed]
  8. The mechanism of antifungal action of (S)-2-amino-4-oxo-5-hydroxypentanoic acid, RI-331: the inhibition of homoserine dehydrogenase in Saccharomyces cerevisiae. Yamaki, H., Yamaguchi, M., Imamura, H., Suzuki, H., Nishimura, T., Saito, H., Yamaguchi, H. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  9. Rapid purification and characterization of homoserine dehydrogenase from Saccharomyces cerevisiae. Yumoto, N., Kawata, Y., Noda, S., Tokushige, M. Arch. Biochem. Biophys. (1991) [Pubmed]
  10. New phenolic inhibitors of yeast homoserine dehydrogenase. Ejim, L., Mirza, I.A., Capone, C., Nazi, I., Jenkins, S., Chee, G.L., Berghuis, A.M., Wright, G.D. Bioorg. Med. Chem. (2004) [Pubmed]
  11. Crystallization and preliminary X-ray diffraction studies of homoserine dehydrogenase from Saccharomyces cerevisiae. DeLaBarre, B., Jacques, S.L., Pratt, C.E., Ruth, D.A., Wright, G.D., Berghuis, A.M. Acta Crystallogr. D Biol. Crystallogr. (1998) [Pubmed]
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