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Chemical Compound Review:

CCRIS 2208 pyrene-4,5-dione

Synonyms: AG-J-80655, ANW-67565, AC1L4OAU, AC1Q6OPY, AK-88042, ...

Zielinska-Park, J. et al., Liang, Y. et al., Kazunga, C. et al.

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Disease relevance of CCRIS 2208

Pyrene-4,5-dione, which accumulates as an end product in some gram-negative bacterial cultures, was further utilized and degraded by Mycobacterium sp. strain KMS [1].
Sphingomonas yanoikuyae strain R1 transformed pyrene to PYRdHD and pyrene-4,5-dione (PYRQ) [2].

High impact information on CCRIS 2208

In this study, two bacterial transformation products of polycyclic aromatic hydrocarbons (PAHs), pyrene-4,5-quinone (P45Q) and fluoranthene-2,3-quinone (F23Q), were evaluated for mutagenicity by measuring aldehydic DNA lesions (ADL) in calf thymus DNA and HeLa S3 cells [3].

References

Study of Biochemical Pathways and Enzymes Involved in Pyrene Degradation by Mycobacterium sp. Strain KMS. Liang, Y., Gardner, D.R., Miller, C.D., Chen, D., Anderson, A.J., Weimer, B.C., Sims, R.C. Appl. Environ. Microbiol. (2006) [Pubmed]
Products from the incomplete metabolism of pyrene by polycyclic aromatic hydrocarbon-degrading bacteria. Kazunga, C., Aitken, M.D. Appl. Environ. Microbiol. (2000) [Pubmed]
Aldehydic DNA lesions in calf thymus DNA and HeLa S3 cells produced by bacterial quinone metabolites of fluoranthene and pyrene. Zielinska-Park, J., Nakamura, J., Swenberg, J.A., Aitken, M.D. Carcinogenesis (2004) [Pubmed]

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