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Chemical Compound Review:

CHEMBL177305 N-(6-aminohexyl)ethanamide

Synonyms: AC1L4QNL, AC1Q5PBQ, CTK8I8712, AR-1J9600, AR-1J9601, ...

Snyder, S.W. et al., Papazafiri, P. et al., Xie, D. et al.

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High impact information on N-Acetyl-1,6-hexanediamine

These results show that in proliferating cultured cells changes in ornithine-decarboxylase-gene transcription can be uncoupled from changes in cell growth and that N-acetyl-1,6-hexanediamine only regulates ornithine decarboxylase expression post-transcriptionally [1].
Hexamethylene bisacetamide (HMBA) is converted by successive deacetylation and oxidation reactions to four major metabolites; in vitro, the initial deacetylated metabolite, N-acetyl-1,6-diaminohexane (NAD-AH), is more potent than HMBA (Synder, S.W.; Egorin, M.J.; Geelhaar, L.A.; Hamburger, A.W.; Callery, P.S. Cancer Res. 48:3613-3616; 1988) [2].
Effects of the monoamine oxidase inhibitor, tranylcypromine, on induction of HL60 cell differentiation by hexamethylene bisacetamide and N-acetyl-1,6-diaminohexane [2].

Analytical, diagnostic and therapeutic context of N-Acetyl-1,6-hexanediamine

Methods of separating N-acetyl-1,6-diaminohexane (NADAH) and its immobilization to diol-silica have been developed [3].

References

Regulation of ornithine decarboxylase in murine erythroleukemic cells by N,N'-diacetyl-1,6-hexanediamine and N-acetyl-1,6-hexanediamine. Papazafiri, P., Osborne, H.B. Eur. J. Biochem. (1989) [Pubmed]
Effects of the monoamine oxidase inhibitor, tranylcypromine, on induction of HL60 cell differentiation by hexamethylene bisacetamide and N-acetyl-1,6-diaminohexane. Snyder, S.W., Egorin, M.J., Zuhowski, E.G., Schimpff, E.C., Callery, P.S. Cancer Commun. (1990) [Pubmed]
Hydrophobic chromatography of the HL-60 cellular fraction co-binding with hexamethylene bisacetamide. Xie, D., Li, S., Ren, L. J. Chromatogr. B Biomed. Sci. Appl. (1997) [Pubmed]

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