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Chemical Compound Review

Jatrosom     (1R)-2-phenylcyclopropan-1- amine

Synonyms: Parnate, Transamine, tranylcypromine, Sulfate, Tranylcypromine, trans-2-Phenylcyclopropylamine, ...
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Disease relevance of tranylcypromine


Psychiatry related information on tranylcypromine


High impact information on tranylcypromine


Chemical compound and disease context of tranylcypromine


Biological context of tranylcypromine


Anatomical context of tranylcypromine

  • We evaluated the effect of both brief (15 min) and prolonged (60 min) exposure of pancreas segments to non-hydrazine (harmine, alpha-methyltryptamine, tranylcypromine and pargyline) and hydrazine (phenelzine, nialamide, iproniazid) type MAO inhibitors [21].
  • Two weeks of daily injections with the monoamine (MAO)-A and -B inhibitor tranylcypromine (8-10 mg/kg, IP) increased BDNF by 15% in the frontal cortex, and 3 weeks treatment increased it by 18% in the frontal cortex and by 29% in the neostriatum [22].
  • Since recovery of MAO B activity approximated the reported half-life of blood platelets, these results suggest that recovery of platelet MAO activity after tranylcypromine treatment is due to the replacement of old platelets by new ones which contain catalytically active MAO B [23].
  • Chronic treatment with tricylic (desipramine and amitriptyline) and monoamine oxidase inhibiting (tranylcypromine) antidepressants did not significantly affect the immunoreactivity levels of G alpha s (both 45- and 52-kDa species), G alpha i1, G alpha i2, G beta 36, and beta 35 in rat cerebral cortex [24].
  • However, in rats previously treated with the MAO inhibitors pargyline or tranylcypromine, the same L-DOPA or free DA treatment resulted in significant increases in both 3-MT and DA sulfate in the hypothalamus, brainstem, and striatum [25].

Associations of tranylcypromine with other chemical compounds


Gene context of tranylcypromine


Analytical, diagnostic and therapeutic context of tranylcypromine


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  2. Cardiac myonecrosis in hypertensive crisis associated with monoamine oxidase inhibitor therapy. Liu, L.X., Rustgi, A.K. Am. J. Med. (1987) [Pubmed]
  3. Monoamine oxidase and catechol-O-methyltransferase activity in hamster and rat insulinomas. Feldman, J.M., Reintgen, D.S., Seigler, H.F. Diabetologia (1979) [Pubmed]
  4. Interactions of levodopa with inhibitors of monoamine oxidase and L-aromatic amino acid decarboxylase. Teychenne, P.F., Calne, D.B., Lewis, P.J., Findley, L.J. Clin. Pharmacol. Ther. (1975) [Pubmed]
  5. Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Lee, M.G., Wynder, C., Schmidt, D.M., McCafferty, D.G., Shiekhattar, R. Chem. Biol. (2006) [Pubmed]
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  9. Treatment of melancholia with tranylcypromine. McGrath, P.J., Quitkin, F.M., Harrison, W., Stewart, J.W. The American journal of psychiatry. (1984) [Pubmed]
  10. Rapid response of severe obsessive-compulsive disorder to tranylcypromine. Jenike, M.A. The American journal of psychiatry. (1981) [Pubmed]
  11. Brain monoamine oxidase A inhibition in cigarette smokers. Fowler, J.S., Volkow, N.D., Wang, G.J., Pappas, N., Logan, J., Shea, C., Alexoff, D., MacGregor, R.R., Schlyer, D.J., Zezulkova, I., Wolf, A.P. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  12. Enhancement of platelet aggregation by tranylcypromine in mouse cerebral microvessels. Rosenblum, W.I., El-Sabban, F. Circ. Res. (1978) [Pubmed]
  13. A parkinsonian syndrome induced in the goldfish by the neurotoxin MPTP. Pollard, H.B., Dhariwal, K., Adeyemo, O.M., Markey, C.J., Caohuy, H., Levine, M., Markey, S., Youdim, M.B. FASEB J. (1992) [Pubmed]
  14. Tranylcypromine and 15-hydroperoxyarachidonate affect arachidonic acid release in addition to inhibition of prostacyclin synthesis in calf aortic endothelial cells. Hong, S.L., Carty, T., Deykin, D. J. Biol. Chem. (1980) [Pubmed]
  15. A case report of successful treatment of dysmorphophobia with tranylcypromine. Jenike, M.A. The American journal of psychiatry. (1984) [Pubmed]
  16. Evidence concerning the involvement of 5-hydroxytryptamine in the locomotor activity produced by amphetamine or tranylcypromine plus L-DOPA. Green, A.R., Kelly, P.H. Br. J. Pharmacol. (1976) [Pubmed]
  17. Effects of tranylcypromine stereoisomers, clorgyline and deprenyl on open field activity during long term lithium administration in rats. Smith, D.F. Psychopharmacology (Berl.) (1976) [Pubmed]
  18. Enhanced 5-hydroxytryptamine-mediated behavioural responses in rats following repeated electroconvulsive shock: relevance to the mechanism of the antidepressive effect of electroconvulsive therapy. Costain, D.W., Green, A.R., Grahame-Smith, D.G. Psychopharmacology (Berl.) (1979) [Pubmed]
  19. Pharmacokinetics of tranylcypromine in patients who are depressed: relationship to cardiovascular effects. Mallinger, A.G., Edwards, D.J., Himmelhoch, J.M., Knopf, S., Ehler, J. Clin. Pharmacol. Ther. (1986) [Pubmed]
  20. Formation and metabolism of catecholestrogens in depressed patients. Banger, M., Hiemke, C., Knuppen, R., Ball, P., Haupt, M., Wiedemann, K. Biol. Psychiatry (1990) [Pubmed]
  21. Monoamine oxidase inhibitors: nature of their interaction with rabbit pancreatic islets to alter insluin secretion. Feldman, J.M., Chapman, B. Diabetologia (1975) [Pubmed]
  22. Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain. Altar, C.A., Whitehead, R.E., Chen, R., Wörtwein, G., Madsen, T.M. Biol. Psychiatry (2003) [Pubmed]
  23. Tranylcypromine lowers human platelet MAO B activity but not concentration. Fritz, R.R., Malek-Ahmadi, P., Rose, R.M., Denney, R.M., Abell, C.W. Biol. Psychiatry (1983) [Pubmed]
  24. Lack of effect of chronic antidepressant treatment on Gs and Gi alpha-subunit protein and mRNA levels in the rat cerebral cortex. Emamghoreishi, M., Warsh, J.J., Sibony, D., Li, P.P. Neuropsychopharmacology (1996) [Pubmed]
  25. Relationship between catechol-O-methyltransferase and phenolsulfotransferase in the metabolism of dopamine in the rat brain. Buu, N.T. J. Neurochem. (1985) [Pubmed]
  26. Tranylcypromine Versus Venlafaxine Plus Mirtazapine Following Three Failed Antidepressant Medication Trials for Depression: A STAR*D Report. McGrath, P.J., Stewart, J.W., Fava, M., Trivedi, M.H., Wisniewski, S.R., Nierenberg, A.A., Thase, M.E., Davis, L., Biggs, M.M., Shores-Wilson, K., Luther, J.F., Niederehe, G., Warden, D., Rush, A.J. The American journal of psychiatry. (2006) [Pubmed]
  27. Adverse reactions to monoamine oxidase inhibitors. Part II. Treatment correlates and clinical management. Rabkin, J.G., Quitkin, F.M., McGrath, P., Harrison, W., Tricamo, E. Journal of clinical psychopharmacology. (1985) [Pubmed]
  28. MAOIs in the contemporary treatment of depression. Thase, M.E., Trivedi, M.H., Rush, A.J. Neuropsychopharmacology (1995) [Pubmed]
  29. Addition of monoamine oxidase inhibitors to carbamazepine: preliminary evidence of safety and antidepressant efficacy in treatment-resistant depression. Ketter, T.A., Post, R.M., Parekh, P.I., Worthington, K. The Journal of clinical psychiatry. (1995) [Pubmed]
  30. Monoamine oxidase inhibitors allow locomotor and rewarding responses to nicotine. Villégier, A.S., Salomon, L., Granon, S., Changeux, J.P., Belluzzi, J.D., Leslie, F.M., Tassin, J.P. Neuropsychopharmacology (2006) [Pubmed]
  31. Evaluation of methoxsalen, tranylcypromine, and tryptamine as specific and selective CYP2A6 inhibitors in vitro. Zhang, W., Kilicarslan, T., Tyndale, R.F., Sellers, E.M. Drug Metab. Dispos. (2001) [Pubmed]
  32. In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (tranylcypromine), and its nonamine analog, cyclopropylbenzene. Taavitsainen, P., Juvonen, R., Pelkonen, O. Drug Metab. Dispos. (2001) [Pubmed]
  33. The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19. Härtter, S., Tybring, G., Friedberg, T., Weigmann, H., Hiemke, C. Pharm. Res. (2002) [Pubmed]
  34. Antidepressant drug treatment induces Arc gene expression in the rat brain. Pei, Q., Zetterström, T.S., Sprakes, M., Tordera, R., Sharp, T. Neuroscience (2003) [Pubmed]
  35. Treatment of imipramine-resistant recurrent depression, IV: A double-blind crossover study of tranylcypromine for anergic bipolar depression. Thase, M.E., Mallinger, A.G., McKnight, D., Himmelhoch, J.M. The American journal of psychiatry. (1992) [Pubmed]
  36. Amphetamine and tranylcypromine in an animal model of depression: pharmacological specificity of the reversal effect. Katz, R.J., Roth, K.A., Schmaltz, K. Neuroscience and biobehavioral reviews. (1981) [Pubmed]
  37. Plasma tranylcypromine: relationship to pharmacokinetic variables and clinical antidepressant actions. Mallinger, A.G., Himmelhoch, J.M., Thase, M.E., Edwards, D.J., Knopf, S. Journal of clinical psychopharmacology. (1990) [Pubmed]
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