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Gene Review

Odc1  -  ornithine decarboxylase, structural 1

Mus musculus

Synonyms: ODC, Odc, Ornithine decarboxylase
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Disease relevance of Odc1


Psychiatry related information on Odc1


High impact information on Odc1

  • We have previously shown that treatment of T lymphocytes with mitogenic ligands induces a rapid activation of ornithine decarboxylase (ODC) through a mechanism that is independent of protein synthesis but requires energy and an intact cytoskeleton [7].
  • Growth signal transduction: rapid activation of covalently bound ornithine decarboxylase during phosphatidylinositol breakdown [7].
  • Here we show by immunoprecipitation experiments and by chemical analyses that ODC is covalently linked to the cell membrane by inositol [7].
  • These isolates were highly potent when evaluated for inhibition of chemically induced preneoplastic lesions in mammary organ culture and inhibition of papillomas in the two-stage mouse skin model, and they appear to function by a unique mechanism at the level of ODC messenger RNA expression [8].
  • Using a cell-free degradation system, we demonstrate that immunodepletion of proteasomes from cell extracts causes almost complete loss of ATP- and antizyme-dependent degradation of ODC [9].

Chemical compound and disease context of Odc1


Biological context of Odc1


Anatomical context of Odc1


Associations of Odc1 with chemical compounds


Physical interactions of Odc1


Enzymatic interactions of Odc1


Regulatory relationships of Odc1

  • Our results demonstrate that AZ1 acts on ODC to enhance the association of ODC with the proteasome, not the rate of its processing [26].
  • These sites conferred Myc responsiveness on heterologous promoter constructs, suggesting that ODC is regulated by Myc at the level of transcription initiation [16].
  • These mice demonstrate for the first time that AZ suppresses tumor growth in an animal cancer model and provide a valuable model system to evaluate the role of ODC and polyamines in skin tumorigenesis [27].
  • Treatment of B16 cells with TPA or alphaMSH rapidly stimulated ODC activity [28].
  • A transgenic mouse line expressing a truncated form of the ornithine decarboxylase (ODC) dominant-negative mutant K69A/C360A under the control of the keratin 6 promoter has been established (K6/ODCdn mice) [29].

Other interactions of Odc1

  • The 37 C-terminal amino acids of ODC harbor an AZ1-modulated recognition determinant [26].
  • The ornithine decarboxylase gene is a transcriptional target of c-Myc [16].
  • Enforced expression of ODC, like c-myc, is sufficient to induce accelerated death following IL-3 withdrawal [17].
  • High constitutive ODC expression and decreased K1 and K10 expression will be useful phenotypic markers for studying the early stages of tumorigenesis in mouse skin [2].
  • This intense staining for ODC occurred consistently in areas with decreased K1 and K10 expression, and, therefore, was associated with an altered pattern of differentiation [2].

Analytical, diagnostic and therapeutic context of Odc1

  • The two transgenic lines had substantial, but different, levels of antizyme in the heart, as detected by Western blotting and by the ability of heart extracts to inhibit exogenous purified ODC [10].
  • The DNA-binding activity of some transcription factors known to bind and transactivate the ODC gene was investigated by gel mobility-shift assay under the same experimental conditions [30].
  • We studied changes in morphogenesis and the expression of the developmental control genes in the embryonic mouse kidney in response to polyamine depletion, using a kidney organ culture approach and reducing the polyamine pools with alpha-difluoromethylornithine (DFMO), an irreversible suicide inhibitor of ornithine decarboxylase (ODC) [31].
  • The major degradation products of ODC, which were separated by high performance liquid chromatography on a reverse-phase column, were identified by N-terminal amino acid sequencing [32].
  • Northern blot analysis revealed that the ODC mRNA level, that was increased 10-fold by testosterone, was decreased 2-fold in catecholamine-depleted hypertrophic kidney [33].


  1. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice. Tang, X., Kim, A.L., Feith, D.J., Pegg, A.E., Russo, J., Zhang, H., Aszterbaum, M., Kopelovich, L., Epstein, E.H., Bickers, D.R., Athar, M. J. Clin. Invest. (2004) [Pubmed]
  2. Ornithine decarboxylase expression in cutaneous papillomas in SENCAR mice is associated with altered expression of keratins 1 and 10. Sundberg, J.P., Erickson, A.A., Roop, D.R., Binder, R.L. Cancer Res. (1994) [Pubmed]
  3. Protective role of arginase in a mouse model of colitis. Gobert, A.P., Cheng, Y., Akhtar, M., Mersey, B.D., Blumberg, D.R., Cross, R.K., Chaturvedi, R., Drachenberg, C.B., Boucher, J.L., Hacker, A., Casero, R.A., Wilson, K.T. J. Immunol. (2004) [Pubmed]
  4. Polyamine depletion by ODC-AdoMetDC antisense adenovirus impairs human colorectal cancer growth and invasion in vitro and in vivo. Zhang, B., Liu, X.X., Zhang, Y., Jiang, C.Y., Hu, H.Y., Gong, L., Liu, M., Teng, Q.S. The journal of gene medicine. (2006) [Pubmed]
  5. Dietary modification of UV-induced epidermal ornithine decarboxylase. Peterson, A.O., McCann, V., Black, H.S. J. Invest. Dermatol. (1980) [Pubmed]
  6. Porphyrin-mediated photosensitization has a weak tumor promoting activity in mouse skin: possible role of in situ-generated reactive oxygen species. Giri, U., Iqbal, M., Athar, M. Carcinogenesis (1996) [Pubmed]
  7. Growth signal transduction: rapid activation of covalently bound ornithine decarboxylase during phosphatidylinositol breakdown. Mustelin, T., Pösö, H., Lapinjoki, S.P., Gynther, J., Andersson, L.C. Cell (1987) [Pubmed]
  8. Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase. Gerhäuser, C., Mar, W., Lee, S.K., Suh, N., Luo, Y., Kosmeder, J., Luyengi, L., Fong, H.H., Kinghorn, A.D., Moriarty, R.M. Nat. Med. (1995) [Pubmed]
  9. Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination. Murakami, Y., Matsufuji, S., Kameji, T., Hayashi, S., Igarashi, K., Tamura, T., Tanaka, K., Ichihara, A. Nature (1992) [Pubmed]
  10. Overexpression of antizyme in the hearts of transgenic mice prevents the isoprenaline-induced increase in cardiac ornithine decarboxylase activity and polyamines, but does not prevent cardiac hypertrophy. Mackintosh, C.A., Feith, D.J., Shantz, L.M., Pegg, A.E. Biochem. J. (2000) [Pubmed]
  11. Arginine and ornithine metabolizing enzymes in testosterone-induced hypertrophic mouse kidney. Manteuffel-Cymborowska, M., Chmurzyńska, W., Peska, M., Grzelakowska-Sztabert, B. Int. J. Biochem. Cell Biol. (1995) [Pubmed]
  12. Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation. Nilsson, J.A., Keller, U.B., Baudino, T.A., Yang, C., Norton, S., Old, J.A., Nilsson, L.M., Neale, G., Kramer, D.L., Porter, C.W., Cleveland, J.L. Cancer Cell (2005) [Pubmed]
  13. Estradiol is trophic for colon cancer in mice: effect on ornithine decarboxylase and c-myc messenger RNA. Narayan, S., Rajakumar, G., Prouix, H., Singh, P. Gastroenterology (1992) [Pubmed]
  14. Antizyme protects against abnormal accumulation and toxicity of polyamines in ornithine decarboxylase-overproducing cells. Suzuki, T., He, Y., Kashiwagi, K., Murakami, Y., Hayashi, S., Igarashi, K. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  15. 20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1. Asher, G., Bercovich, Z., Tsvetkov, P., Shaul, Y., Kahana, C. Mol. Cell (2005) [Pubmed]
  16. The ornithine decarboxylase gene is a transcriptional target of c-Myc. Bello-Fernandez, C., Packham, G., Cleveland, J.L. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  17. Ornithine decarboxylase is a mediator of c-Myc-induced apoptosis. Packham, G., Cleveland, J.L. Mol. Cell. Biol. (1994) [Pubmed]
  18. Loss of p27Kip1 from cyclin E/cyclin-dependent kinase (CDK) 2 but not from cyclin D1/CDK4 complexes in cells transformed by polyamine biosynthetic enzymes. Ravanko, K., Järvinen, K., Paasinen-Sohns, A., Hölttä, E. Cancer Res. (2000) [Pubmed]
  19. Helicobacter pylori induces macrophage apoptosis by activation of arginase II. Gobert, A.P., Cheng, Y., Wang, J.Y., Boucher, J.L., Iyer, R.K., Cederbaum, S.D., Casero, R.A., Newton, J.C., Wilson, K.T. J. Immunol. (2002) [Pubmed]
  20. c-Myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathways. Packham, G., Porter, C.W., Cleveland, J.L. Oncogene (1996) [Pubmed]
  21. Degradation of antizyme inhibitor, an ornithine decarboxylase homologous protein, is ubiquitin-dependent and is inhibited by antizyme. Bercovich, Z., Kahana, C. J. Biol. Chem. (2004) [Pubmed]
  22. Helicobacter pylori-induced macrophage apoptosis requires activation of ornithine decarboxylase by c-Myc. Cheng, Y., Chaturvedi, R., Asim, M., Bussière, F.I., Scholz, A., Xu, H., Casero, R.A., Wilson, K.T. J. Biol. Chem. (2005) [Pubmed]
  23. Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells. Sako, T., Yuspa, S.H., Herald, C.L., Pettit, G.R., Blumberg, P.M. Cancer Res. (1987) [Pubmed]
  24. Spermidine-induced destabilization of ornithine decarboxylase (ODC) is mediated by accumulation of antizyme in ODC-overproducing variant cells. Kanamoto, R., Kameji, T., Iwashita, S., Igarashi, K., Hayashi, S. J. Biol. Chem. (1993) [Pubmed]
  25. A rat monoclonal antibody which interacts with mammalian ornithine decarboxylase at an epitope involved in phosphorylation. Donato, N.J., Ware, C.F., Byus, C.V. Biochim. Biophys. Acta (1986) [Pubmed]
  26. Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate. Zhang, M., Pickart, C.M., Coffino, P. EMBO J. (2003) [Pubmed]
  27. Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis. Feith, D.J., Shantz, L.M., Pegg, A.E. Cancer Res. (2001) [Pubmed]
  28. Regulation of ornithine decarboxylase in B16 mouse melanoma cells: synergistic activation of melanogenesis by alphaMSH and ornithine decarboxylase inhibition. Sanchez Mas, J., Martijnez-Esparza, M., Bastida, C.M., Solano, F., Penafiel, R., Garcija-Borron, J.C. Biochim. Biophys. Acta (2002) [Pubmed]
  29. Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation. Shantz, L.M., Guo, Y., Sawicki, J.A., Pegg, A.E., O'Brien, T.G. Carcinogenesis (2002) [Pubmed]
  30. Inhibition of the expression of ornithine decarboxylase and c-Myc by cell-permeant ceramide in difluoromethylornithine-resistant leukaemia cells. Flamigni, F., Faenza, I., Marmiroli, S., Stanic', I., Giaccari, A., Muscari, C., Stefanelli, C., Rossoni, C. Biochem. J. (1997) [Pubmed]
  31. Polyamines are involved in murine kidney development controlling expression of c-ret, E-cadherin, and Pax2/8 genes. Loikkanen, I., Lin, Y., Railo, A., Pajunen, A., Vainio, S. Differentiation (2005) [Pubmed]
  32. ATP- and antizyme-dependent endoproteolysis of ornithine decarboxylase to oligopeptides by the 26 S proteasome. Tokunaga, F., Goto, T., Koide, T., Murakami, Y., Hayashi, S., Tamura, T., Tanaka, K., Ichihara, A. J. Biol. Chem. (1994) [Pubmed]
  33. Catecholamines are required for androgen-induced ODC expression but not for hypertrophy of mouse kidney. Manteuffel-Cymborowska, M., Peska, M., Chmurzyńska, W., Grzelakowska-Sztabert, B. Biochim. Biophys. Acta (1997) [Pubmed]
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