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Chemical Compound Review

AG-J-73101     [8-(5-chloropyridin-2-yl)-7- oxo-2,5,8...

Synonyms: SureCN11485705, CTK5B0635, AR-1G9843, AR-1G9844, FT-0666252, ...
 
 
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High impact information on N-Desmethylzopiclone

  • In human liver microsomes, zopiclone was metabolized into N-desmethyl-zopiclone (ND-Z) and N-oxide-zopiclone (NO-Z) with the following K(m) and V(m) of 78 +/- 5 and 84 +/- 19 microM, 45 +/- 1 and 54 +/- 5 pmol/min/mg for ND-Z and NO-Z generation, respectively [1].
 

Analytical, diagnostic and therapeutic context of N-Desmethylzopiclone

References

  1. Cytochrome P-450 3A4 and 2C8 are involved in zopiclone metabolism. Becquemont, L., Mouajjah, S., Escaffre, O., Beaune, P., Funck-Brentano, C., Jaillon, P. Drug Metab. Dispos. (1999) [Pubmed]
  2. Development of a radioimmunoassay for the determination of N-desmethylzopiclone in urine. Mannaert, E., Daenens, P. The Analyst. (1994) [Pubmed]
  3. Development of a fluorescence polarization immunoassay for the routine detection of N-desmethylzopiclone in urine samples. Mannaert, E., Daenens, P. The Analyst. (1996) [Pubmed]
 
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