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Chemical Compound Review

DHS-I     (2S,3S,4S,5R)-6- [[(3S,4R,4aR,6aR,6bS,8aR...

Synonyms: AC1L4U20, Dehydrosoyasaponin I
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High impact information on Dehydrosoyasaponin I


Biological context of Dehydrosoyasaponin I

  • Indeed, MaxiK channel properties, defined by coassembly of beta1 and alpha subunits, were equivalent in young versus old, for example in terms of (i) activation kinetics, (ii) sensitivity to Ca2+ levels > 1 microm (iii) dehydrosoyasaponin-I-induced activation, and (iv) iberiotoxin blockade [5].


  1. A cysteine-rich domain defined by a novel exon in a slo variant in rat adrenal chromaffin cells and PC12 cells. Saito, M., Nelson, C., Salkoff, L., Lingle, C.J. J. Biol. Chem. (1997) [Pubmed]
  2. Mechanism of maxi-K channel activation by dehydrosoyasaponin-I. Giangiacomo, K.M., Kamassah, A., Harris, G., McManus, O.B. J. Gen. Physiol. (1998) [Pubmed]
  3. Function and clustered expression of MaxiK channels in cerebral myocytes remain intact with aging. Nishimaru, K., Eghbali, M., Stefani, E., Toro, L. Exp. Gerontol. (2004) [Pubmed]
  4. Insecticidal components from field pea extracts: soyasaponins and lysolecithins. Taylor, W.G., Fields, P.G., Sutherland, D.H. J. Agric. Food Chem. (2004) [Pubmed]
  5. Functional and molecular evidence of MaxiK channel beta1 subunit decrease with coronary artery ageing in the rat. Nishimaru, K., Eghbali, M., Lu, R., Marijic, J., Stefani, E., Toro, L. J. Physiol. (Lond.) (2004) [Pubmed]
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