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Chemical Compound Review:

DHS-I (2S,3S,4S,5R)-6- [[(3S,4R,4aR,6aR,6bS,8aR...

Synonyms: AC1L4U20, Dehydrosoyasaponin I

Nishimaru, K. et al., Nishimaru, K. et al., Taylor, W.G. et al., Saito, M. et al., Giangiacomo, K.M. et al.

Taylor, Fields, Sutherland,

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High impact information on Dehydrosoyasaponin I

Furthermore, a beta-subunit-dependent Slo channel activator, dehydrosoyasaponin I, was without effect on chromaffin cell BK current [1].
Mechanism of maxi-K channel activation by dehydrosoyasaponin-I [2].
Sensitivity to nanomolar concentrations of dehydrosoyasaponin-I that activates channels formed by alpha and beta subunits is also the same in young and old myocytes [3].
However, dehydrosoyasaponin I could be isolated from saponin-enriched fractions with a reversed phase column of styrene/divinylbenzene operated at alkaline pH [4].

Biological context of Dehydrosoyasaponin I

Indeed, MaxiK channel properties, defined by coassembly of beta1 and alpha subunits, were equivalent in young versus old, for example in terms of (i) activation kinetics, (ii) sensitivity to Ca2+ levels > 1 microm (iii) dehydrosoyasaponin-I-induced activation, and (iv) iberiotoxin blockade [5].

References

A cysteine-rich domain defined by a novel exon in a slo variant in rat adrenal chromaffin cells and PC12 cells. Saito, M., Nelson, C., Salkoff, L., Lingle, C.J. J. Biol. Chem. (1997) [Pubmed]
Mechanism of maxi-K channel activation by dehydrosoyasaponin-I. Giangiacomo, K.M., Kamassah, A., Harris, G., McManus, O.B. J. Gen. Physiol. (1998) [Pubmed]
Function and clustered expression of MaxiK channels in cerebral myocytes remain intact with aging. Nishimaru, K., Eghbali, M., Stefani, E., Toro, L. Exp. Gerontol. (2004) [Pubmed]
Insecticidal components from field pea extracts: soyasaponins and lysolecithins. Taylor, W.G., Fields, P.G., Sutherland, D.H. J. Agric. Food Chem. (2004) [Pubmed]
Functional and molecular evidence of MaxiK channel beta1 subunit decrease with coronary artery ageing in the rat. Nishimaru, K., Eghbali, M., Lu, R., Marijic, J., Stefani, E., Toro, L. J. Physiol. (Lond.) (2004) [Pubmed]

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