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Gene Review

Kcnma1  -  potassium channel, calcium activated large...

Rattus norvegicus

Synonyms: BK channel, BKCA alpha, BKCa, Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel, subfamily M subunit alpha-1, ...
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Disease relevance of Kcnma1


Psychiatry related information on Kcnma1


High impact information on Kcnma1

  • Our results indicate instead that somatostatin stimulates BK channel activity through protein dephosphorylation [6].
  • Thus, the hormonal stress axis is likely to control the excitable properties of epinephrine-secreting cells by regulating alternative splicing of Slo messenger RNA [7].
  • These results support the novel concept that changes in BK channel subunit composition regulate arterial smooth muscle function [1].
  • We conclude that downregulation of the beta1 subunit of the BK channel contributes to vascular dysfunction in hypertension [1].
  • Ethanol inhibition of BK transients was caused by a reduction in Ca(2+) spark frequency (-49%), a subsarcolemmal Ca(2+) signal that evokes the BK transients, and a direct inhibition of BK channel steady-state activity (-44%) [8].

Chemical compound and disease context of Kcnma1

  • A new study demonstrates that angiotensin-induced hypertension results in a marked decrease in expression of the beta subunit of the BK channel, suggesting a role for this critical subunit in the regulation of vascular tone [9].
  • Upregulation of the BK channel alpha subunit contributes to the enhanced depressor response caused by tempol in DOCA-salt hypertension [10].

Biological context of Kcnma1

  • Moreover, they reveal down-regulation by splice variants as a new mechanism that may contribute to the diverse levels of MaxiK channel expression in non-excitable and excitable cells [11].
  • STREX alternative-exon adds to Slo channel a phosphorylation sequence that can invert protein kinase A (PKA) regulation from excitatory to inhibitory [12].
  • This study pinpoints the Ca(2+) spark/BK channel negative-feedback mechanism as the primary effector of ethanol vasoconstriction [8].
  • The expression pattern of Slo is consistent with its targeting into a presynaptic compartment, which implies an important role in neural transmission [13].
  • BK channel activation and vasorelaxation by iloprost were similar in lean and ZDF rats [14].

Anatomical context of Kcnma1

  • We hypothesize that Slo splicing in adrenal chromaffin cells in vivo is differentially regulated by the integrative, concentration- and time-dependent actions of glucocorticoids and androgens, with potentially important ramifications for stress-evoked catecholamine secretion [15].
  • We identified a novel MaxiK alpha subunit splice variant (SV1) from rat myometrium that is also present in brain [11].
  • Expression of Ca2+-activated BK channel mRNA and its splice variants in the rat cochlea [16].
  • Extensive splicing of BK channel transcripts, however, does not seem to be used in mammalian hair cells as is done in lower vertebrates [16].
  • Thus, we report (i) steroidal regulation of Slo splicing in the pituitary and (ii) participation of the male gonads in this regulation [17].

Associations of Kcnma1 with chemical compounds


Regulatory relationships of Kcnma1

  • In contrast, stimulation of P2Y2 receptors led to a 20% inhibition of co-expressed BK channel activity, a response that was sensitive to TEA [20].

Other interactions of Kcnma1


Analytical, diagnostic and therapeutic context of Kcnma1


  1. Modulation of the molecular composition of large conductance, Ca(2+) activated K(+) channels in vascular smooth muscle during hypertension. Amberg, G.C., Bonev, A.D., Rossow, C.F., Nelson, M.T., Santana, L.F. J. Clin. Invest. (2003) [Pubmed]
  2. The maxi-K channel opener BMS-204352 attenuates regional cerebral edema and neurologic motor impairment after experimental brain injury. Cheney, J.A., Weisser, J.D., Bareyre, F.M., Laurer, H.L., Saatman, K.E., Raghupathi, R., Gribkoff, V., Starrett , J.E., McIntosh, T.K. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  3. Involvement of BKCa alpha subunit tyrosine phosphorylation in vascular hyporesponsiveness of superior mesenteric artery following hemorrhagic shock in rats. Zhou, R., Liu, L., Hu, D. Cardiovasc. Res. (2005) [Pubmed]
  4. BK channel activity determines the extent of cell degeneration after oxygen and glucose deprivation: a study in organotypical hippocampal slice cultures. Rundén-Pran, E., Haug, F.M., Storm, J.F., Ottersen, O.P. Neuroscience (2002) [Pubmed]
  5. 4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunction. Hewawasam, P., Fan, W., Ding, M., Flint, K., Cook, D., Goggins, G.D., Myers, R.A., Gribkoff, V.K., Boissard, C.G., Dworetzky, S.I., Starrett, J.E., Lodge, N.J. J. Med. Chem. (2003) [Pubmed]
  6. Somatostatin stimulates Ca(2+)-activated K+ channels through protein dephosphorylation. White, R.E., Schonbrunn, A., Armstrong, D.L. Nature (1991) [Pubmed]
  7. Control of alternative splicing of potassium channels by stress hormones. Xie, J., McCobb, D.P. Science (1998) [Pubmed]
  8. Essential role for smooth muscle BK channels in alcohol-induced cerebrovascular constriction. Liu, P., Xi, Q., Ahmed, A., Jaggar, J.H., Dopico, A.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  9. Hypertension: beta testing. Kotlikoff, M., Hall, I. J. Clin. Invest. (2003) [Pubmed]
  10. Activation of vascular BK channel by tempol in DOCA-salt hypertensive rats. Xu, H., Bian, X., Watts, S.W., Hlavacova, A. Hypertension (2005) [Pubmed]
  11. A novel MaxiK splice variant exhibits dominant-negative properties for surface expression. Zarei, M.M., Zhu, N., Alioua, A., Eghbali, M., Stefani, E., Toro, L. J. Biol. Chem. (2001) [Pubmed]
  12. Alternative splicing of Slo channel gene programmed by estrogen, progesterone and pregnancy. Zhu, N., Eghbali, M., Helguera, G., Song, M., Stefani, E., Toro, L. FEBS Lett. (2005) [Pubmed]
  13. Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: targeting to axons and nerve terminals. Knaus, H.G., Schwarzer, C., Koch, R.O., Eberhart, A., Kaczorowski, G.J., Glossmann, H., Wunder, F., Pongs, O., Garcia, M.L., Sperk, G. J. Neurosci. (1996) [Pubmed]
  14. Impaired arachidonic acid-mediated activation of large-conductance Ca2+-activated K+ channels in coronary arterial smooth muscle cells in Zucker Diabetic Fatty rats. Lu, T., Wang, X.L., He, T., Zhou, W., Kaduce, T.L., Katusic, Z.S., Spector, A.A., Lee, H.C. Diabetes (2005) [Pubmed]
  15. Opposing actions of adrenal androgens and glucocorticoids on alternative splicing of Slo potassium channels in bovine chromaffin cells. Lai, G.J., McCobb, D.P. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  16. Expression of Ca2+-activated BK channel mRNA and its splice variants in the rat cochlea. Langer, P., Gründer, S., Rüsch, A. J. Comp. Neurol. (2003) [Pubmed]
  17. Regulation of Slo potassium channel alternative splicing in the pituitary by gonadal testosterone. Mahmoud, S.F., McCobb, D.P. J. Neuroendocrinol. (2004) [Pubmed]
  18. A cysteine-rich domain defined by a novel exon in a slo variant in rat adrenal chromaffin cells and PC12 cells. Saito, M., Nelson, C., Salkoff, L., Lingle, C.J. J. Biol. Chem. (1997) [Pubmed]
  19. A novel conotoxin from Conus betulinus, kappa-BtX, unique in cysteine pattern and in function as a specific BK channel modulator. Fan, C.X., Chen, X.K., Zhang, C., Wang, L.X., Duan, K.L., He, L.L., Cao, Y., Liu, S.Y., Zhong, M.N., Ulens, C., Tytgat, J., Chen, J.S., Chi, C.W., Zhou, Z. J. Biol. Chem. (2003) [Pubmed]
  20. P2Y2 and P2Y4 receptors regulate pancreatic Ca(2+)-activated K+ channels differently. Hede, S.E., Amstrup, J., Klaerke, D.A., Novak, I. Pflugers Arch. (2005) [Pubmed]
  21. Leptin-induced dynamic alterations in the actin cytoskeleton mediate the activation and synaptic clustering of BK channels. O'Malley, D., Irving, A.J., Harvey, J. FASEB J. (2005) [Pubmed]
  22. Adenylate cyclase 5 and KCa1.1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle. Ivanov, A., Gerzanich, V., Ivanova, S., Denhaese, R., Tsymbalyuk, O., Simard, J.M. J. Physiol. (Lond.) (2006) [Pubmed]
  23. Somatostatin stimulates BKCa channels in rat pituitary tumor cells through lipoxygenase metabolites of arachidonic acid. Duerson, K., White, R.E., Jiang, F., Schonbrunn, A., Armstrong, D.L. Neuropharmacology (1996) [Pubmed]
  24. Essential roles of Homer-1a in homeostatic regulation of pyramidal cell excitability: a possible link to clinical benefits of electroconvulsive shock. Sakagami, Y., Yamamoto, K., Sugiura, S., Inokuchi, K., Hayashi, T., Kato, N. Eur. J. Neurosci. (2005) [Pubmed]
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