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Chemical Compound Review:

3alpha5betaHS sodium4- [[(3R,5R,10S,13S,17S)-17- ethanoyl...

Synonyms:

Weaver, C.E. et al., Sadri-Vakili, G. et al.

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Disease relevance of 4-[[(3R,5R,10S,13R,17S)-17-ethanoyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-4-oxo-butanoic acid

Intravenous administration of 3alpha5betaHS to rats (at a nonsedating dose) following focal cerebral ischemia induced by middle cerebral artery occlusion significantly reduces cortical and subcortical infarct size [1].
The in vitro and in vivo neuroprotective effects of 3alpha5betaHS demonstrate that this steroid represents a new class of potentially useful therapeutic agents for the treatment of stroke and certain neurodegenerative diseases that involve over activation of NMDA receptors [1].

High impact information on 4-[[(3R,5R,10S,13R,17S)-17-ethanoyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-4-oxo-butanoic acid

Our laboratory has previously shown that the synthetic neuroactive steroid 3alpha-hydroxy-5beta-pregnan-20-one hemisuccinate (3alpha5betaHS) is a negative modulator of NMDA receptors in vitro [2].

References

Neuroprotective activity of a new class of steroidal inhibitors of the N-methyl-D-aspartate receptor. Weaver, C.E., Marek, P., Park-Chung, M., Tam, S.W., Farb, D.H. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
Inhibition of NMDA-induced striatal dopamine release and behavioral activation by the neuroactive steroid 3alpha-hydroxy-5beta-pregnan-20-one hemisuccinate. Sadri-Vakili, G., Johnson, D.W., Janis, G.C., Gibbs, T.T., Pierce, R.C., Farb, D.H. J. Neurochem. (2003) [Pubmed]

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