Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Lactoyl-PH4 2-amino-6-(2- hydroxypropanoyl)-5,6,7,8...

Synonyms: AG-K-92616, SureCN1858785, CHEBI:17248, HMDB02065, AC1Q5GME, ...

Katoh, S. et al., Milstien, S. et al.

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High impact information on Lactoyl-PH4

We have also purified extensively from brain an enzyme, distinct from sepiapterin reductase, that catalyzes the TPNH-dependent reduction of 6-pyruvoyl-tetrahydropterin to 6-lactoyl-tetrahydropterin [1].
Isomerization of 6-lactoyl tetrahydropterin by sepiapterin reductase [2].

Associations of Lactoyl-PH4 with other chemical compounds

Isomerization of 6-1'-oxo-2'-hydroxypropyl tetrahydropterin (6-lactoyl tetrahydropterin) to 6-1'-hydroxy-2'-oxopropyl tetrahydropterin has been attributed to sepiapterin reductase [2].

References

Biosynthesis of tetrahydrobiopterin: conversion of dihydroneopterin triphosphate to tetrahydropterin intermediates. Milstien, S., Kaufman, S. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
Isomerization of 6-lactoyl tetrahydropterin by sepiapterin reductase. Katoh, S., Sueoka, T. J. Biochem. (1987) [Pubmed]

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