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Chemical Compound Review

Dyspropterin     1-(2-amino-4-oxo-5,6,7,8- tetrahydro-1H...

Synonyms: PPH4, SureCN188413, AG-H-62763, SureCN2510640, ACMC-20lp9i, ...
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Disease relevance of Dyspropterin


High impact information on Dyspropterin


Biological context of Dyspropterin


Anatomical context of Dyspropterin


Associations of Dyspropterin with other chemical compounds


Gene context of Dyspropterin


Analytical, diagnostic and therapeutic context of Dyspropterin


  1. Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase I is stimulated by interferon-gamma, and 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively present. Werner, E.R., Werner-Felmayer, G., Fuchs, D., Hausen, A., Reibnegger, G., Yim, J.J., Pfleiderer, W., Wachter, H. J. Biol. Chem. (1990) [Pubmed]
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  4. Human liver 6-pyruvoyl tetrahydropterin reductase is biochemically and immunologically indistinguishable from aldose reductase. Steinerstauch, P., Wermuth, B., Leimbacher, W., Curtius, H.C. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  5. Sepiapterin reductases from Chlorobium tepidum and Chlorobium limicola catalyze the synthesis of L-threo-tetrahydrobiopterin from 6-pyruvoyltetrahydropterin. Choi, Y.K., Jun, S.R., Cha, E.Y., Park, J.S., Park, Y.S. FEMS Microbiol. Lett. (2005) [Pubmed]
  6. Structure of Chlorobium tepidum sepiapterin reductase complex reveals the novel substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin. Supangat, S., Seo, K.H., Choi, Y.K., Park, Y.S., Son, D., Han, C.D., Lee, K.H. J. Biol. Chem. (2006) [Pubmed]
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  9. Hyperphenylalaninemia due to deficiency of 6-pyruvoyl tetrahydropterin synthase. Unusual gene dosage effect in heterozygotes. Scriver, C.R., Clow, C.L., Kaplan, P., Niederwieser, A. Hum. Genet. (1987) [Pubmed]
  10. Tetrahydrobiopterin and cytokines. Werner, E.R., Werner-Felmayer, G., Wachter, H. Proc. Soc. Exp. Biol. Med. (1993) [Pubmed]
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  12. Progression of 6-pyruvoyl-tetrahydropterin synthase deficiency from a peripheral into a central phenotype. Ponzone, A., Blau, N., Guardamagna, O., Ferrero, G.B., Dianzani, I., Endres, W. J. Inherit. Metab. Dis. (1990) [Pubmed]
  13. Cloning and tissue expression of 6-pyruvoyl tetrahydropterin synthase and xanthine dehydrogenase from Poecilia reticulata. Ben, J., Lim, T.M., Phang, V.P., Chan, W.K. Mar. Biotechnol. (2003) [Pubmed]
  14. Analysis of the tetrahydrobiopterin synthesizing system during maturation of murine reticulocytes. Kerler, F., Hültner, L., Ziegler, I., Katzenmaier, G., Bacher, A. J. Cell. Physiol. (1990) [Pubmed]
  15. Antenatal diagnosis of tetrahydrobiopterin deficiency by quantification of pterins in amniotic fluid and enzyme activity in fetal and extrafetal tissue. Blau, N., Kierat, L., Matasovic, A., Leimbacher, W., Heizmann, C.W., Guardamagna, O., Ponzone, A. Clin. Chim. Acta (1994) [Pubmed]
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  17. Purification and characterization of 6-pyruvoyl tetrahydropterin synthase from human pituitary gland. Guzman, J., Redweik, U., Schoedon, G., Hunziker, P., Wiestler, O.D., Heizmann, C.W., Blau, N. Enzyme (1992) [Pubmed]
  18. The pathway from GTP to tetrahydrobiopterin: three-dimensional structures of GTP cyclohydrolase I and 6-pyruvoyl tetrahydropterin synthase. Auerbach, G., Nar, H. Biol. Chem. (1997) [Pubmed]
  19. High-performance liquid chromatographic methods for the quantification of tetrahydrobiopterin biosynthetic enzymes. Werner, E.R., Werner-Felmayer, G., Wachter, H. J. Chromatogr. B, Biomed. Appl. (1996) [Pubmed]
  20. Purification, crystallization and preliminary crystallographic analysis of archaeal 6-pyruvoyl tetrahydrobiopterin synthase homologue PH0634 from Pyrococcus horikoshii OT3. Bagautdinov, B., Sugahara, M., Kunishima, N. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2007) [Pubmed]
  21. Dyspropterin, an intermediate formed from dihydroneopterin triphosphate in the biosynthetic pathway of tetrahydrobiopterin. Masada, M., Akino, M., Sueoka, T., Katoh, S. Biochim. Biophys. Acta (1985) [Pubmed]
  22. Molecular characterization of a nonsuppressible allele (prC4) of the Drosophila purple gene. Kim, N., Kim, J., Kim, H., Park, D., Yim, J. Mol. Cells (1997) [Pubmed]
  23. Chromosomal location of two human genes encoding tetrahydrobiopterin-metabolizing enzymes: 6-pyruvoyl-tetrahydropterin synthase maps to 11q22.3-q23.3, and pterin-4 alpha-carbinolamine dehydratase maps to 10q22. Thöny, B., Heizmann, C.W., Mattei, M.G. Genomics (1994) [Pubmed]
  24. Purification and properties of the enzymes from Drosophila melanogaster that catalyze the conversion of dihydroneopterin triphosphate to the pyrimidodiazepine precursor of the drosopterins. Wiederrecht, G.J., Brown, G.M. J. Biol. Chem. (1984) [Pubmed]
  25. Differential diagnosis of hyperphenylalaninaemia by a combined phenylalanine-tetrahydrobiopterin loading test. Ponzone, A., Guardamagna, O., Spada, M., Ferraris, S., Ponzone, R., Kierat, L., Blau, N. Eur. J. Pediatr. (1993) [Pubmed]
  26. D-threo-tetrahydrobiopterin is synthesized via 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum Ax2. Choi, Y.K., Park, J.S., Kong, J.S., Morio, T., Park, Y.S. FEBS Lett. (2005) [Pubmed]
  27. Production of monoclonal antibodies against human 6-pyruvoyl tetrahydropterin synthase and immunocytochemical localization of the enzyme. Guzman, J., Schoedon, G., Blau, N. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  28. 1H-NMR and mass spectrometric studies of tetrahydropterins. Evidence for the structure of 6-pyruvoyl tetrahydropterin, an intermediate in the biosynthesis of tetrahydrobiopterin. Ghisla, S., Kuster, T., Steinerstauch, P., Leimbacher, W., Richter, W.J., Raschdorf, F., Dahinden, R., Curtius, H.C. Eur. J. Biochem. (1990) [Pubmed]
  29. Prenatal diagnosis of 6-pyruvoyl tetrahydropterin synthase deficiency in seven subjects. Shintaku, H., Hsiao, K.J., Liu, T.T., Imamura, T., Hase, Y., Chen, R.G., Isshiki, G., Oura, T. J. Inherit. Metab. Dis. (1994) [Pubmed]
  30. Diagnosis and treatment of 6-pyruvoyl-tetrahydropterin synthase deficiency. Shintaku, H., Asada, M., Sawada, Y. Brain Dev. (2000) [Pubmed]
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