Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Gal-1,3-glcnac N-[(2R,3R,4R,5R)-4,5,6- trihydroxy-1-oxo-3...

Synonyms: FT-0639944, AC1L56H5, Galactosyl-1,3-N-acetylglucosamine

Vetere, A. et al., Lee, K.P. et al., Akamatsu, S. et al.

Vetere, Miletich, Bosco, Paoletti,

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Disease relevance of Lacto-N-biose I

The disaccharide lacto-N-biose I was obtained by use of p-nitrophenyl beta-D-galactopyranoside as the donor, 2-acetamido-2-deoxy-D-glucopyranose as the acceptor and Xanthomonas manihotis beta-D-galactosidase as the catalyst [1].

High impact information on Lacto-N-biose I

In vitro CFT1 fucosyltransferase activity utilizes LacNAc > 3'sialyl-LacNAc acceptors with almost no utilization of other neutral type II (lactose, 2-fucosyllactose), or type I (lacto-N-biose I) acceptors [2].
Lacto-N-biose I (Gal beta 1-->3GlcNAc beta, Lewis(c) [Le(c)]) and 6-O-methyl-Le(c) (Gal beta 1-->3[6OMe]GlcNAc beta) were synthesized and covalently attached to bovine serum albumin (BSA) [3].

References

Regiospecific glycosidase-assisted synthesis of lacto-N-biose I (Galbeta1-3GlcNAc) and 3'-sialyl-lacto-N-biose I (NeuAcalpha2-3Galbeta1-3GlcNAc). Vetere, A., Miletich, M., Bosco, M., Paoletti, S. Eur. J. Biochem. (2000) [Pubmed]
Molecular cloning and characterization of CFT1, a developmentally regulated avian alpha(1,3)-fucosyltransferase gene. Lee, K.P., Carlson, L.M., Woodcock, J.B., Ramachandra, N., Schultz, T.L., Davis, T.A., Lowe, J.B., Thompson, C.B., Larsen, R.D. J. Biol. Chem. (1996) [Pubmed]
Alpha 2-->3sialyltransferase associated with the synthesis of CA 19-9 in colorectal tumors. Akamatsu, S., Yazawa, S., Tachikawa, T., Furuta, T., Okaichi, Y., Nakamura, J., Asao, T., Nagamachi, Y. Cancer (1996) [Pubmed]

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