Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Adpalphas [[(2R,3S,4R,5R)-5-(6- aminopurin-9-yl)-3,4...

Synonyms: CHEMBL575257, ADP alpha S, AC1L56SE, Adenosine 5'-O-(1-thiodiphosphate)

Greco, N.J., Burnstock, G. et al., Cusack, N.J. et al.

Greco,

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High impact information on ADP alpha S

After RNA from CMK 11-5 cells was microinjected into Xenopus oocytes, only ADP and ADP-alpha-S stimulated 45Ca2+ efflux, which was not observed with ATP, 2-methylthio-ATP, alpha, beta-methylene-ATP, ATP-gamma-S, ATP-alpha-S, or adenosine [1].
The Rp diastereoisomers of the phosphorothioate analogues, ATP-alpha-S and ADP-alpha-S were respectively 7 and 3 times more effective than the Sp diastereoisomers in causing relaxation of the taenia coli [2].
Adenosine 5'-O-(1-thiodiphosphate) (ADP-alpha-S) and adenosine 5'-O-(2-thiodiphosphate) (ADP-beta-S) act at the ADP receptor and achieve the same maximal rate of human platelet aggregation as each other [3].

Gene context of ADP alpha S

Pharmacological responsiveness of CMK 11-5 cells to nucleotides paralleled those of platelets, in which ADP and ADP-alpha-S are active as agonists and ATP and ATP-alpha-S are inactive as agonists but act as antagonists [1].

References

Functional expression of a P2T ADP receptor in Xenopus oocytes injected with megakaryocyte (CMK 11-5) RNA. Greco, N.J. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
Effects of phosphorothioate analogues of ATP, ADP and AMP on guinea-pig taenia coli and urinary bladder. Burnstock, G., Cusack, N.J., Meldrum, L.A. Br. J. Pharmacol. (1984) [Pubmed]
Differential inhibition by adenosine or by prostaglandin E1 of human platelet aggregation induced by adenosine 5'-O-(1-thiodiphosphate) and adenosine 5'-O-(2-thiodiphosphate). Cusack, N.J., Hourani, S.M. Br. J. Pharmacol. (1982) [Pubmed]

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