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Chemical Compound Review

Mesatp cpd     [[[(2R,3S,4R)-5-(6-amino-2- methylsulfanyl...

Synonyms: AR-1C9486, AC1L3345, AC1Q6S3C, 2MeSATP, 43170-89-4, ...
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Disease relevance of Mesatp cpd


High impact information on Mesatp cpd


Biological context of Mesatp cpd


Anatomical context of Mesatp cpd


Associations of Mesatp cpd with other chemical compounds


Gene context of Mesatp cpd

  • Absence of the responses of alphabeta-methylene ATP and 2-methylthio-ATP excluded functionally active P2X3, P2X4, and P2Y1 receptors as far as [Ca2+]i increase is concerned [21].
  • 2-Methylthio-ATP (0.1-10 microM), an agonist that can act at P2Y1 receptors, did not contract arteries or veins, whereas UTP, an agonist at rat P2Y2/P2Y4 receptors, contracted veins (EC(50) = 15 microM) and arteries (EC(50) = 24 microM) [22].
  • In 1321N1 cells stably expressing the human P2Y6 receptor, the formation of IP3 was stimulated by nucleotides with the following order of potency: UDP > 5-bromo-UPT > UTP > ADP > 2-methylthio-ATP >> ATP [23].
  • This effect was mediated by P2Y1 receptors because (1) 2-methylthio-ATP (2meSATP) was the most potent agonist, (2) 2'-deoxy-N6-methyladenosine-3',5'-bisphosphate diammonium (MRS2179) abolished this effect, and (3) this increase in IPSC frequency was not observed in the transgenic mice lacking P2Y1 receptor proteins [24].
  • 5. While all cells tested (n = 52) responded to the P2Y-purinoceptor agonist, 2-methylthio-ATP, only a subpopulation of astrocytes (n = 67/93) was responsive to UTP [11].

Analytical, diagnostic and therapeutic context of Mesatp cpd


  1. Purinoceptors mediating relaxation and spasm in the rat gastric fundus. Matharu, M.S., Hollingsworth, M. Br. J. Pharmacol. (1992) [Pubmed]
  2. Interaction of ethanol with inducible nitric oxide synthase messenger RNA and protein: direct effects on autacoids and endotoxin in vivo. Greenberg, S.S., Ouyang, J., Zhao, X., Xie, J., Wang, J.F., Giles, T.D. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  3. Mechanisms of adenosine 5'-triphosphate-induced dopamine release in the rat nucleus accumbens in vivo. Krügel, U., Kittner, H., Illes, P. Synapse (2001) [Pubmed]
  4. Protection of mice from endotoxic death by 2-methylthio-ATP. Proctor, R.A., Denlinger, L.C., Leventhal, P.S., Daugherty, S.K., van de Loo, J.W., Tanke, T., Firestein, G.S., Bertics, P.J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  5. Coexpression of P2Y and P2U receptors on aortic endothelial cells. Comparison of cell localization and signaling pathways. Communi, D., Raspe, E., Pirotton, S., Boeynaems, J.M. Circ. Res. (1995) [Pubmed]
  6. ATP-evoked increases in intracellular calcium in neurons and glia from the dorsal spinal cord. Salter, M.W., Hicks, J.L. J. Neurosci. (1994) [Pubmed]
  7. Detection of human P2X7 nucleotide receptor polymorphisms by a novel monocyte pore assay predictive of alterations in lipopolysaccharide-induced cytokine production. Denlinger, L.C., Angelini, G., Schell, K., Green, D.N., Guadarrama, A.G., Prabhu, U., Coursin, D.B., Bertics, P.J., Hogan, K. J. Immunol. (2005) [Pubmed]
  8. Diadenosine polyphosphates in insulin-secreting cells: interaction with specific receptors and degradation. Verspohl, E.J., Johannwille, B. Diabetes (1998) [Pubmed]
  9. Mechanism of extracellular ATP-induced proliferation of vascular smooth muscle cells. Yu, S.M., Chen, S.F., Lau, Y.T., Yang, C.M., Chen, J.C. Mol. Pharmacol. (1996) [Pubmed]
  10. Relative contribution of P2U- and P2Y-purinoceptors to endothelium-dependent vasodilatation in the golden hamster isolated mesenteric arterial bed. Ralevic, V., Burnstock, G. Br. J. Pharmacol. (1996) [Pubmed]
  11. A novel P2-purinoceptor expressed by a subpopulation of astrocytes from the dorsal spinal cord of the rat. Ho, C., Hicks, J., Salter, M.W. Br. J. Pharmacol. (1995) [Pubmed]
  12. Extracellular ATP increases cation fluxes in human erythrocytes by activation of the P2X7 receptor. Sluyter, R., Shemon, A.N., Barden, J.A., Wiley, J.S. J. Biol. Chem. (2004) [Pubmed]
  13. Regulation of inducible nitric oxide synthase expression by macrophage purinoreceptors and calcium. Denlinger, L.C., Fisette, P.L., Garis, K.A., Kwon, G., Vazquez-Torres, A., Simon, A.D., Nguyen, B., Proctor, R.A., Bertics, P.J., Corbett, J.A. J. Biol. Chem. (1996) [Pubmed]
  14. Effects of purine and pyrimidine nucleotides on intracellular Ca2+ in human eosinophils: activation of purinergic P2Y receptors. Mohanty, J.G., Raible, D.G., McDermott, L.J., Pelleg, A., Schulman, E.S. J. Allergy Clin. Immunol. (2001) [Pubmed]
  15. Agonist action of adenosine triphosphates at the human P2Y1 receptor. Palmer, R.K., Boyer, J.L., Schachter, J.B., Nicholas, R.A., Harden, T.K. Mol. Pharmacol. (1998) [Pubmed]
  16. ATP-induced secretion in PC12 cells and photoaffinity labeling of receptors. Rhoads, A.R., Parui, R., Vu, N.D., Cadogan, R., Wagner, P.D. J. Neurochem. (1993) [Pubmed]
  17. Purinergic receptor regulation of signal transduction in NCB-20 cells. Garritsen, A., Zhang, Y., Cooper, D.M. Mol. Pharmacol. (1992) [Pubmed]
  18. Differential heterologous and homologous desensitization of two receptors for ATP (P2y purinoceptors and nucleotide receptors) coexisting on endothelial cells. Wilkinson, G.F., Purkiss, J.R., Boarder, M.R. Mol. Pharmacol. (1994) [Pubmed]
  19. ATP inhibits Mg(2+) uptake in MDCT cells via P2X purinoceptors. Dai, L.J., Kang, H.S., Kerstan, D., Ritchie, G., Quamme, G.A. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  20. Vasoconstrictor and vasodilator responses to various agonists in the rat perfused mesenteric arterial bed: selective inhibition by PPADS of contractions mediated via P2x-purinoceptors. Windscheif, U., Ralevic, V., Bäumert, H.G., Mutschler, E., Lambrecht, G., Burnstock, G. Br. J. Pharmacol. (1994) [Pubmed]
  21. Membrane-specific expression of functional purinergic receptors in normal human nasal epithelial cells. Kim, C.H., Kim, S.S., Choi, J.Y., Shin, J.H., Kim, J.Y., Namkung, W., Lee, J.G., Lee, M.G., Yoon, J.H. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  22. Differential localization of P2 receptor subtypes in mesenteric arteries and veins of normotensive and hypertensive rats. Galligan, J.J., Hess, M.C., Miller, S.B., Fink, G.D. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  23. Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Communi, D., Parmentier, M., Boeynaems, J.M. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  24. Direct excitation of inhibitory interneurons by extracellular ATP mediated by P2Y1 receptors in the hippocampal slice. Kawamura, M., Gachet, C., Inoue, K., Kato, F. J. Neurosci. (2004) [Pubmed]
  25. The purinergic P2 receptor antagonist pyridoxalphosphate-6-azophenyl-2'4'-disulphonic acid prevents both the acute locomotor effects of amphetamine and the behavioural sensitization caused by repeated amphetamine injections in rats. Kittner, H., Krügel, U., Illes, P. Neuroscience (2001) [Pubmed]
  26. Interaction between P2Y and NMDA receptors in layer V pyramidal neurons of the rat prefrontal cortex. Wirkner, K., Köles, L., Thümmler, S., Luthardt, J., Poelchen, W., Franke, H., Fürst, S., Illes, P. Neuropharmacology (2002) [Pubmed]
  27. Purinergic modulation of neuronal activity in the mesolimbic dopaminergic system in vivo. Krügel, U., Kittner, H., Franke, H., Illes, P. Synapse (2003) [Pubmed]
  28. Evidence for sympathetic, purinergic transmission in the iris dilator muscle of the rabbit. Muramatsu, I., Kigoshi, S., Oda, Y. Jpn. J. Pharmacol. (1994) [Pubmed]
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