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Chemical Compound Review:

AC1L59WI (2S)-1-[(2S)-2-[[(2S)-1- [(2S)-2-amino-3-(4...

Synonyms: 74171-19-0, Tyr-pro-phe-pro, beta-Casomorphin 4, beta-Casomorphin 4 (ox), Tyrosyl-prolyl-phenylalanyl-proline

Widy-Tyszkiewicz, E. et al., Brantl, V. et al., Koch, G. et al.

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High impact information on Tyrosyl-prolyl-phenylalanyl-proline

The effects of intraventricular injection of beta-casomorphin-4, morphiceptin and deltakephalin (DTLET) on hot water tail flick and tail compression responses were investigated in Wistar Albino Glaxo (WAG) and spontaneously hypertensive rats (SHR) [1].
Opioid activities of human beta-casomorphin-4, -5, -7 and -8 and, for comparison, of the corresponding bovine beta-casomorphins were studied in the guinea-pig ileum preparation [2].
C-terminal amidation of beta-casomorphin-4 and (-5) increased opioid potency in both organ preparations (GPI, MVD) and affinity to mu-binding sites in brain whereas binding to delta-sites was diminished [3].

Associations of Tyrosyl-prolyl-phenylalanyl-proline with other chemical compounds

Analgesic activity of morphiceptin, beta-casomorphin-4, and deltakephalin in normotensive Wistar-Glaxo and spontaneously hypertensive rats [1].

References

Analgesic activity of morphiceptin, beta-casomorphin-4, and deltakephalin in normotensive Wistar-Glaxo and spontaneously hypertensive rats. Widy-Tyszkiewicz, E., Członkowski, A. Peptides (1989) [Pubmed]
Opioid activities of human beta-casomorphins. Koch, G., Wiedemann, K., Teschemacher, H. Naunyn Schmiedebergs Arch. Pharmacol. (1985) [Pubmed]
Antinociceptive potencies of beta-casomorphin analogs as compared to their affinities towards mu and delta opiate receptor sites in brain and periphery. Brantl, V., Pfeiffer, A., Herz, A., Henschen, A., Lottspeich, F. Peptides (1982) [Pubmed]

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