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Rats, Inbred SHR

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  1. Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats. Aitman, T.J., Gotoda, T., Evans, A.L., Imrie, H., Heath, K.E., Trembling, P.M., Truman, H., Wallace, C.A., Rahman, A., Doré, C., Flint, J., Kren, V., Zidek, V., Kurtz, T.W., Pravenec, M., Scott, J. Nat. Genet. (1997) [Pubmed]
  2. Effect of angiotensin-converting enzyme inhibition on myocardial fibrosis and function in hypertrophied and failing myocardium from the spontaneously hypertensive rat. Brooks, W.W., Bing, O.H., Robinson, K.G., Slawsky, M.T., Chaletsky, D.M., Conrad, C.H. Circulation (1997) [Pubmed]
  3. Postinfarction survival and inducibility of ventricular arrhythmias in the spontaneously hypertensive rat : effects of ramipril and hydralazine. Nguyen, T., El Salibi, E., Rouleau, J.L. Circulation (1998) [Pubmed]
  4. Regulation of myosin heavy chain expression in the hearts of hypertensive rats by testosterone. Morano, I., Gerstner, J., Rüegg, J.C., Ganten, U., Ganten, D., Vosberg, H.P. Circ. Res. (1990) [Pubmed]
  5. Temporal relationship between the decrease in arterial pressure and sodium retention in conscious spontaneously hypertensive rats with carbon tetrachloride-induced cirrhosis. López, C., Jiménez, W., Arroyo, V., Clària, J., La Villa, G., Asbert, M., Gaya, J., Rivera, F., Rodés, J. Hepatology (1991) [Pubmed]
  6. Antihypertensive effect of alcohol in spontaneously hypertensive rats. Howe, P.R., Rogers, P.F., Smith, R.M. Hypertension (1989) [Pubmed]
  7. Alpha4beta2 nicotinic acetylcholine receptor activation ameliorates impairment of spontaneous alternation behavior in stroke-prone spontaneously hypertensive rats, an animal model of attention deficit hyperactivity disorder. Ueno, K., Togashi, H., Matsumoto, M., Ohashi, S., Saito, H., Yoshioka, M. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  8. Differential neuronal responses to angiotensin III from the subfornical organ of normotensive and spontaneously hypertensive rats. Yang, C.C., Chan, J.Y., Pan, J.T., Chan, S.H. Brain Res. (1994) [Pubmed]
  9. Locomotor hyperactivity in hypertensive rats. Tsai, C.F., Lin, M.T. Pharmacology (1988) [Pubmed]
  10. Effects of endomorphin-2 on arterial blood pressure and pain threshold in spontaneously hypertensive rats and modification of these effects by beta-funaltrexamine and nor-binaltorphimine. Makulska-Nowak, H.E., Gumułka, S.W., Lipkowski, A.W., Rawa, M.A. Life Sci. (2001) [Pubmed]
  11. Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats. Pravenec, M., Landa, V., Zidek, V., Musilova, A., Kren, V., Kazdova, L., Aitman, T.J., Glazier, A.M., Ibrahimi, A., Abumrad, N.A., Qi, N., Wang, J.M., St Lezin, E.M., Kurtz, T.W. Nat. Genet. (2001) [Pubmed]
  12. Exaggerated salt appetite of spontaneously hypertensive rats is decreased by central angiotensin-converting enzyme blockade. DiNicolantonio, R., Hutchinson, J.S., Mendelsohn, F.A. Nature (1982) [Pubmed]
  13. Decreased renal prostaglandin catabolism precedes onset of hypertension in the developing spontaneously hypertensive rat. Pace-Asciak, C.R. Nature (1976) [Pubmed]
  14. Depressed cardiac cyclic GMP-dependent protein kinase in spontaneously hypertensive rats and its further depression by guanethidine. Kuo, J.F., Davis, C.W., Tse, J. Nature (1976) [Pubmed]
  15. Renal permeability alteration precedes hypertension and involves bradykinin in the spontaneously hypertensive rat. Plante, G.E., Bissonnette, M., Sirois, M.G., Regoli, D., Sirois, P. J. Clin. Invest. (1992) [Pubmed]
  16. L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats. Chen, P.Y., Sanders, P.W. J. Clin. Invest. (1991) [Pubmed]
  17. Purification of parathyroid hypertensive factor from plasma of spontaneously hypertensive rats. Benishin, C.G., Lewanczuk, R.Z., Pang, P.K. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  18. Direct gene delivery of human tissue kallikrein reduces blood pressure in spontaneously hypertensive rats. Wang, C., Chao, L., Chao, J. J. Clin. Invest. (1995) [Pubmed]
  19. Role of angiotensin in autoregulation of cerebral blood flow. Paulson, O.B., Waldemar, G., Andersen, A.R., Barry, D.I., Pedersen, E.V., Schmidt, J.F., Vorstrup, S. Circulation (1988) [Pubmed]
  20. Aminopeptidase A inhibitors as potential central antihypertensive agents. Reaux, A., Fournie-Zaluski, M.C., David, C., Zini, S., Roques, B.P., Corvol, P., Llorens-Cortes, C. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  21. Diabetes-induced alterations in atrial natriuretic peptide gene expression in Wistar-Kyoto and spontaneously hypertensive rats. Matsubara, H., Mori, Y., Yamamoto, J., Inada, M. Circ. Res. (1990) [Pubmed]
  22. Renal vasoconstriction by the endothelial cell-derived peptide endothelin in spontaneously hypertensive rats. Hirata, Y., Matsuoka, H., Kimura, K., Fukui, K., Hayakawa, H., Suzuki, E., Sugimoto, T., Sugimoto, T., Yanagisawa, M., Masaki, T. Circ. Res. (1989) [Pubmed]
  23. Vascular and brain dopamine beta-hydroxylase activity in young spontaneously hypertensive rats. Nagatsu, T., Ikuta, K., Numata, Y., Kato, T., Sano, M. Science (1976) [Pubmed]
  24. Dysregulation of HSG triggers vascular proliferative disorders. Chen, K.H., Guo, X., Ma, D., Guo, Y., Li, Q., Yang, D., Li, P., Qiu, X., Wen, S., Xiao, R.P., Tang, J. Nat. Cell Biol. (2004) [Pubmed]
  25. Atrial natriuretic peptide regulation of noradrenaline release in the anterior hypothalamic area of spontaneously hypertensive rats. Peng, N., Oparil, S., Meng, Q.C., Wyss, J.M. J. Clin. Invest. (1996) [Pubmed]
  26. Impairment of selectin-mediated leukocyte adhesion to venular endothelium in spontaneously hypertensive rats. Suematsu, M., Suzuki, H., Tamatani, T., Iigou, Y., DeLano, F.A., Miyasaka, M., Forrest, M.J., Kannagi, R., Zweifach, B.W., Ishimura, Y. J. Clin. Invest. (1995) [Pubmed]
  27. Antihypertensive treatment improves endothelium-dependent hyperpolarization in the mesenteric artery of spontaneously hypertensive rats. Onaka, U., Fujii, K., Abe, I., Fujishima, M. Circulation (1998) [Pubmed]
  28. beta-Endorphin: possible involvement in the antihypertensive effect of central alpha-receptor activation. Kunos, G., Farsang, C., Ramirez-Gonzales, M.D. Science (1981) [Pubmed]
  29. Retinal dystrophy: development retarded by galactose feeding in spontaneously hypertensive rats. Frank, R.N., Keirn, R.J., Keirn, G.V., Mancini, M.A., Khoury, J.K. Science (1986) [Pubmed]
  30. Role of the D1A dopamine receptor in the pathogenesis of genetic hypertension. Albrecht, F.E., Drago, J., Felder, R.A., Printz, M.P., Eisner, G.M., Robillard, J.E., Sibley, D.R., Westphal, H.J., Jose, P.A. J. Clin. Invest. (1996) [Pubmed]
  31. Renal prostaglandin synthesis in the spontaneously hypertensive rat. Dunn, M.J. J. Clin. Invest. (1976) [Pubmed]
  32. Effects of thromboxane synthase inhibition on vascular responsiveness in the in vivo rat mesentery. Jackson, E.K. J. Clin. Invest. (1985) [Pubmed]
  33. Mitogen-activated protein/extracellular signal-regulated kinase inhibition attenuates angiotensin II-mediated signaling and contraction in spontaneously hypertensive rat vascular smooth muscle cells. Touyz, R.M., El Mabrouk, M., He, G., Wu, X.H., Schiffrin, E.L. Circ. Res. (1999) [Pubmed]
  34. Induction of heme oxygenase-1 and stimulation of cGMP production by hemin in aortic tissues from hypertensive rats. Ndisang, J.F., Wu, L., Zhao, W., Wang, R. Blood (2003) [Pubmed]
  35. Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitro. Sivasubramanian, N., Adhikary, G., Sil, P.C., Sen, S. J. Biol. Chem. (1996) [Pubmed]
  36. Defective fatty acid uptake in the spontaneously hypertensive rat is a primary determinant of altered glucose metabolism, hyperinsulinemia, and myocardial hypertrophy. Hajri, T., Ibrahimi, A., Coburn, C.T., Knapp, F.F., Kurtz, T., Pravenec, M., Abumrad, N.A. J. Biol. Chem. (2001) [Pubmed]
  37. Role of endothelium in endothelin-evoked contractions in the rat aorta. Taddei, S., Vanhoutte, P.M. Hypertension (1993) [Pubmed]
  38. Decreased content of integral membrane calcium-binding protein (IMCAL) in tissues of the spontaneously hypertensive rat. Kowarski, S., Cowen, L.A., Schachter, D. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  39. Renal function of conscious spontaneously hypertensive rats. Beirewaltes, W.H., Arendshorst, W.J. Circ. Res. (1978) [Pubmed]
  40. Unique resistance to guanethidine-induced chemical sympathectomy of spontaneously hypertensive rats: a resistance overcome by treatment with antibody to nerve growth factor. Johnson, E.M., Macia, R.A. Circ. Res. (1979) [Pubmed]
  41. Combined effect of neonatal sympathectomy and adrenal demedullation on blood pressure and vascular changes in spontaneously hypertensive rats. Lee, R.M., Borkowski, K.R., Leenen, F.H., Tsoporis, J., Coughlin, M. Circ. Res. (1991) [Pubmed]
  42. The angiotensin II receptor antagonist candesartan cilexetil (TCV-116) ameliorates retinal disorders in rats. Nagisa, Y., Shintani, A., Nakagawa, S. Diabetologia (2001) [Pubmed]
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