Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

KST-1A7197 (3S,10S,13R,14S,17R)-3- hydroxy-4,4,10,13...

Synonyms: AR-1A5054, AC1L4O7B, 32-Oxo-dhl, 59200-40-7, Lanosten-3-ol-32-al, ...

Aoyama, Y. et al., Trzaskos, J.M. et al., Trzaskos, J.M. et al.

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High impact information on 32-Oxo-dhl

Deformylation of 32-oxo-24,25-dihydrolanosterol by the purified cytochrome P-45014DM (lanosterol 14 alpha-demethylase) from yeast evidence confirming the intermediate step of lanosterol 14 alpha-demethylation [1].
In situ accumulation of 3 beta-hydroxylanost-8-en-32-aldehyde in hepatocyte cultures. A putative regulator of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity [2].
Conditions have been established which promote the accumulation of the dihydrolanosterol C-32 demethylation intermediates lanost-8-en-3 beta,32-diol and 3 beta-hydroxylanost-8-en-32-aldehyde with intact hepatic microsomes [3].

Gene context of 32-Oxo-dhl

32-Oxo-24,25-dihydrolanosterol (32-oxo-DHL) was deformylated to 4,4-dimethylcholesta-8,14-dien-3 beta-ol, the product of 14 alpha-demethylation of 24,25-dihydro-lanosterol (DHL), by the reconstituted lanosterol 14 alpha-demethylase system consisting of cytochrome P-45014DM and NADPH-cytochrome P-450 reductase of yeast [1].

References

Deformylation of 32-oxo-24,25-dihydrolanosterol by the purified cytochrome P-45014DM (lanosterol 14 alpha-demethylase) from yeast evidence confirming the intermediate step of lanosterol 14 alpha-demethylation. Aoyama, Y., Yoshida, Y., Sonoda, Y., Sato, Y. J. Biol. Chem. (1989) [Pubmed]
In situ accumulation of 3 beta-hydroxylanost-8-en-32-aldehyde in hepatocyte cultures. A putative regulator of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity. Trzaskos, J.M., Favata, M.F., Fischer, R.T., Stam, S.H. J. Biol. Chem. (1987) [Pubmed]
Mechanistic studies of lanosterol C-32 demethylation. Conditions which promote oxysterol intermediate accumulation during the demethylation process. Trzaskos, J.M., Fischer, R.T., Favata, M.F. J. Biol. Chem. (1986) [Pubmed]

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