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Chemical Compound Review:

Deriphat 3-(2-carboxyethyl-dodecyl- amino)propanoic...

Synonyms: AC1L2DUT, 17066-08-9, EINECS 241-127-3, 3655-00-3 (di-hydrochloride salt), N-(2-Carboxyethyl)-N-dodecyl-beta-alanine

Markwell, J. et al., Agalidis, I. et al., Kent, N.E. et al., Santini, C. et al.

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High impact information on Deriphat

Treatment of isolated chloroplastic envelope membranes with 0.5% Deriphat 160 (N-lauryl-beta-imminodipropionate) causes general solubilization but preserves an envelope sub-membrane fragment which is fractionated by centrifugation in a sucrose gradient and by chromatography on a column of DEAE-Sephacel [1].
Detergent solubilization of membrane fractions showed that Triton X-100 nonselectively solubilizes both the cytoplasmic membrane and the outer membrane, whereas Deriphat 160 selectively solubilizes the cytoplasmic membrane [2].
The tetraheme cytochrome c subunit of the Rubrivivax gelatinosus reaction center was isolated in the presence of octyl beta-D-thioglucoside by ammonium sulfate precipitation and solubilization at pH 9 in a solution of Deriphat 160 [3].

Analytical, diagnostic and therapeutic context of Deriphat

An estimate of the molecular mass and the results of Deriphat/PAGE analysis suggest that a reaction centre is present in each half of the structure resolved by electron microscopy [4].

References

Isolation of a carotenoid-containing sub-membrane particle from the chloroplastic envelope outer membrane of pea (Pisum sativum). Markwell, J., Bruce, B.D., Keegstra, K. J. Biol. Chem. (1992) [Pubmed]
Heat modifiability and detergent solubility of outer membrane proteins of Rhodopseudomonas sphaeroides. Kent, N.E., Wisnieski, B.J. J. Bacteriol. (1983) [Pubmed]
Purification, redox and spectroscopic properties of the tetraheme cytochrome c isolated from Rubrivivax gelatinosus. Agalidis, I., Othman, S., Boussac, A., Reiss-Husson, F., Desbois, A. Eur. J. Biochem. (1999) [Pubmed]
Three-dimensional structure of the higher-plant photosystem II reaction centre and evidence for its dimeric organization in vivo. Santini, C., Tidu, V., Tognon, G., Ghiretti Magaldi, A., Bassi, R. Eur. J. Biochem. (1994) [Pubmed]

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