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Chemical Compound Review

Deriphat     3-(2-carboxyethyl-dodecyl- amino)propanoic...

Synonyms: AC1L2DUT, 17066-08-9, EINECS 241-127-3, 3655-00-3 (di-hydrochloride salt), N-(2-Carboxyethyl)-N-dodecyl-beta-alanine
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High impact information on Deriphat

  • Treatment of isolated chloroplastic envelope membranes with 0.5% Deriphat 160 (N-lauryl-beta-imminodipropionate) causes general solubilization but preserves an envelope sub-membrane fragment which is fractionated by centrifugation in a sucrose gradient and by chromatography on a column of DEAE-Sephacel [1].
  • Detergent solubilization of membrane fractions showed that Triton X-100 nonselectively solubilizes both the cytoplasmic membrane and the outer membrane, whereas Deriphat 160 selectively solubilizes the cytoplasmic membrane [2].
  • The tetraheme cytochrome c subunit of the Rubrivivax gelatinosus reaction center was isolated in the presence of octyl beta-D-thioglucoside by ammonium sulfate precipitation and solubilization at pH 9 in a solution of Deriphat 160 [3].

Analytical, diagnostic and therapeutic context of Deriphat

  • An estimate of the molecular mass and the results of Deriphat/PAGE analysis suggest that a reaction centre is present in each half of the structure resolved by electron microscopy [4].


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