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Chemical Compound Review:

AG-E-52577 1-[2,4-dihydroxy-3-(3- methylbut-2...

Synonyms: CTK8G0367, AC1L4WK5

Chen, Y.G. et al., Akihisa, T. et al.

Chen, Song, Hai, Lv, Fang, Halaweish, Liao, Akihisa, Tokuda, Hasegawa, Ukiya, Kimura, Enjo, Suzuki, Nishino,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on C08648

Two DNA cleavage agents, meso-dihydroguaiaretic acid (1) and isobavachalcone (2) together with the known alpha-ylangene, beta-sitosterol, daucosterol, pentacosane, hexacosanic acid and cerotic acid 1-monoglyceride were isolated from the stem barks of Kadsura ananosma Kerr for the first time [1].

Analytical, diagnostic and therapeutic context of C08648

Further, isobavachalcone (4) exhibited inhibitory effects on skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter [2].

References

Compounds with DNA cleaving activity from Kadsura ananosma. Chen, Y.G., Song, X.P., Hai, L.N., Lv, Y.P., Fang, A., Halaweish, F., Liao, X.R. Die Pharmazie. (2006) [Pubmed]
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects. Akihisa, T., Tokuda, H., Hasegawa, D., Ukiya, M., Kimura, Y., Enjo, F., Suzuki, T., Nishino, H. J. Nat. Prod. (2006) [Pubmed]

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