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MeSH Review

Carcinogenicity Tests

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Disease relevance of Carcinogenicity Tests


High impact information on Carcinogenicity Tests


Biological context of Carcinogenicity Tests


Associations of Carcinogenicity Tests with chemical compounds


Gene context of Carcinogenicity Tests

  • In addition, the first appearance of tumors in nu/nu mice is delayed in tumorigenicity tests with cells that over-express Egr-1 and tumor growth is suppressed compared to control cells [12].
  • The lack of mutagenic activity of T-2 toxin and diacetoxyscirpenol supports the negative results that have been obtained with in vivo carcinogenicity tests [13].
  • It is proposed that bacterial mutagenicity reflects the cancer initiation potency, whereas the AhR affinity reflects the promotive effect of some PAH at the high doses applied in rodent carcinogenicity tests [14].
  • Further, vanicoside B exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumors initiated with an NO donor, NOR-1 [15].
  • The results indicate that p53+/- mice have no practical advantages for use in short-term carcinogenicity tests of HCAs [16].


  1. Toxicology of sorbic acid and sorbates. Walker, R. Food additives and contaminants. (1990) [Pubmed]
  2. Carcinogenicity test of acetoxime in MRC-Wistar rats. Mirvish, S.S., Salmasi, S., Runge, R.G. J. Natl. Cancer Inst. (1982) [Pubmed]
  3. Carcinogenicity test of six nitrosamides and a nitrosocyanamide administered orally to rats. Bulay, O., Mirvish, S.S., Garcia, H., Pelfrene, A.F., Gold, B., Eagen, M. J. Natl. Cancer Inst. (1979) [Pubmed]
  4. Chromosomal mapping of genes controlling development, histological grade, depth of invasion, and size of rat stomach carcinomas. Ushijima, T., Yamamoto, M., Suzui, M., Kuramoto, T., Yoshida, Y., Nomoto, T., Tatematsu, M., Sugimura, T., Nagao, M. Cancer Res. (2000) [Pubmed]
  5. Adenovirus-mediated expression of PML suppresses growth and tumorigenicity of prostate cancer cells. He, D., Mu, Z.M., Le, X., Hsieh, J.T., Pong, R.C., Chung, L.W., Chang, K.S. Cancer Res. (1997) [Pubmed]
  6. Mouse skin carcinogenicity tests of the flame retardants tris(2,3-dibromopropyl)phosphate, tetrakis(hydroxymethyl)phosphonium chloride, and polyvinyl bromide. Van Duuren, B.L., Loewengart, G., Seidman, I., Smith, A.C., Melchionne, S. Cancer Res. (1978) [Pubmed]
  7. Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis. Sakurai, N., Kozuka, M., Tokuda, H., Nobukuni, Y., Takayasu, J., Nishino, H., Kusano, A., Kusano, G., Nagai, M., Sakurai, Y., Lee, K.H. Bioorg. Med. Chem. (2003) [Pubmed]
  8. Detection of mutagenic impurities in carcinogens and noncarcinogens by high-pressure liquid chromatography and the Salmonella/microsome test. Donahue, E.V., McCann, J., Ames, B.N. Cancer Res. (1978) [Pubmed]
  9. Short-term carcinogenicity testing of a potent murine intestinal mutagen, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), in Apc1638N transgenic mice. Sørensen, I.K., Kristiansen, E., Mortensen, A., van Kranen, H., van Kreijl, C., Fodde, R., Thorgeirsson, S.S. Carcinogenesis (1997) [Pubmed]
  10. Procarcinogen activation by rat and human mammary extracts. Maack, C.A., Silva, M.H., Petrakis, N.L., Lee, R.E., Lyon, M. Carcinogenesis (1986) [Pubmed]
  11. Long-term in vivo carcinogenicity tests of potassium bromate, sodium hypochlorite, and sodium chlorite conducted in Japan. Kurokawa, Y., Takayama, S., Konishi, Y., Hiasa, Y., Asahina, S., Takahashi, M., Maekawa, A., Hayashi, Y. Environ. Health Perspect. (1986) [Pubmed]
  12. Suppression of v-sis-dependent transformation by the transcription factor, Egr-1. Huang, R.P., Darland, T., Okamura, D., Mercola, D., Adamson, E.D. Oncogene (1994) [Pubmed]
  13. Lack of mutagenicity to Salmonella typhimurium of some Fusarium mycotoxins. Wehner, F.C., Marasas, W.F., Thiel, P.G. Appl. Environ. Microbiol. (1978) [Pubmed]
  14. Relevance of different biological assays in assessing initiating and promoting properties of polycyclic aromatic hydrocarbons with respect to carcinogenic potency. Sjögren, M., Ehrenberg, L., Rannug, U. Mutat. Res. (1996) [Pubmed]
  15. Cancer chemopreventive activity of phenylpropanoid esters of sucrose, vanicoside B and lapathoside A, from Polygonum lapathifolium. Takasaki, M., Konoshima, T., Kuroki, S., Tokuda, H., Nishino, H. Cancer Lett. (2001) [Pubmed]
  16. Heterozygous p53-deficient mice are not susceptible to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) carcinogenicity. Park, C.B., Kim, D.J., Uehara, N., Takasuka, N., Hiroyasu, B.T., Tsuda, H. Cancer Lett. (1999) [Pubmed]
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