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Chemical Compound Review

Valienamine     (1S,4S,5S,6R)-4-amino-2...

Synonyms: CHEMBL1230806, SureCN3960550, CHEBI:40504, KST-1A4953, CTK4H9548, ...
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Disease relevance of Valienamine

  • We examined the inhibitory effect of three pseudo-aminosugars (validamine, valienamine, and valiolamine), which were isolated from the broth of Streptomyces hygroscopicus, on the oligosaccharide-processing glucosidases I and II involved in glycoprotein biosynthesis in rat liver [1].
  • As these metabolites, some of which contain valienamine, are among the most potent antidiabetic agents thus far discovered, the molecular detection of specific metabolite-producing actinomycetes may prove a crucial step in current attempts to expand the scope and diversity of natural-product discovery [2].

High impact information on Valienamine


  1. Inhibitory effect of pseudo-aminosugars on oligosaccharide glucosidases I and II and on lysosomal alpha-glucosidase from rat liver. Takeuchi, M., Kamata, K., Yoshida, M., Kameda, Y., Matsui, K. J. Biochem. (1990) [Pubmed]
  2. Molecular detection of alpha-glucosidase inhibitor-producing actinomycetes. Hyun, C.G., Kim, S.Y., Hur, J.H., Seo, M.J., Suh, J.W., Kim, S.O. J. Microbiol. (2005) [Pubmed]
  3. The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose. Stratmann, A., Mahmud, T., Lee, S., Distler, J., Floss, H.G., Piepersberg, W. J. Biol. Chem. (1999) [Pubmed]
  4. Inhibition of porcine small intestinal sucrase by valienamine. Zheng, Y.G., Shentu, X.P., Shen, Y.C. Journal of enzyme inhibition and medicinal chemistry. (2005) [Pubmed]
  5. Quantitative analysis of valienamine in the microbial degradation of validamycin A after derivatization with p-nitrofluorobenzene by reversed-phase high-performance liquid chromatography. Chen, X., Zheng, Y., Shen, Y. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2005) [Pubmed]
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