Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Trasidrex 3-chloro-9- (cyclopentylmethyl)-7,7- dioxo...

Synonyms: AG-K-46884, AC1Q3ETB, CTK5D3790, AR-1H1284, AC1L4Y5M, ...

Ebbutt, A.F. et al., Forrest, W.A., Forrest, W.A., Forrest, W.A.

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Disease relevance of Trasidrex

Experience with Trasidrex in the management of inadequately controlled hypertension in general practice [1].

High impact information on Trasidrex

In those patients where blood pressure control with a single agent was proving difficult, the transfer to one or two tablets daily of the fixed combination (Trasidrex) produced a very satisfactory outcome in the large majority of cases [2].
Treatment was changed to one or two tablets daily of Trasidrex (160 mg oxprenolol hydrochloride in a sustained release formulation and 0.25 mg cyclopenthiazide) with a subsequent improvement, 4 weeks later, in blood pressure control [3].
A multicentre, open study of general practice patients with essential hypertension who were currently being treated with oxprenolol and cyclopenthiazide was undertaken in which the patients were transferred to Trasidrex for 12 weeks [4].
A multicentre study examining the substitution of Trasidrex for the free combination of Slow-Trasicor and Navidrex-K [4].

References

Experience with Trasidrex in the management of inadequately controlled hypertension in general practice. Forrest, W.A. The British journal of clinical practice. (1980) [Pubmed]
The treatment of hypertension in older patients: a double-blind, between-patient study, in previously treated patients comparing a diuretic, a beta-receptor antagonist, and their fixed combination. Forrest, W.A. J. Int. Med. Res. (1981) [Pubmed]
An open comparison between free and a fixed combination of diuretic and beta-blocker in the management of essential hypertension. Forrest, W.A. J. Int. Med. Res. (1980) [Pubmed]
A multicentre study examining the substitution of Trasidrex for the free combination of Slow-Trasicor and Navidrex-K. Ebbutt, A.F., Elsdon-Dew, R.W. J. Int. Med. Res. (1979) [Pubmed]

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