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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Multicenter Studies

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Disease relevance of Multicenter Studies


Psychiatry related information on Multicenter Studies


High impact information on Multicenter Studies


Chemical compound and disease context of Multicenter Studies


Biological context of Multicenter Studies


Anatomical context of Multicenter Studies


Associations of Multicenter Studies with chemical compounds


Gene context of Multicenter Studies

  • Prevalence and evolutionary origins of the del(GJB6-D13S1830) mutation in the DFNB1 locus in hearing-impaired subjects: a multicenter study [36].
  • Human papillomavirus type 16 and TP53 mutation in oral cancer: matched analysis of the IARC multicenter study [37].
  • A double-blind, randomized, multicenter study in which patients with active RA were treated with tenidap 120 mg/day, hydroxychloroquine 400 mg/day and piroxicam 20 mg/day, or piroxicam alone 20 mg/day, for 24 weeks [38].
  • DESIGN, SETTING, AND SUBJECTS: In a multicenter study of 219 PTC patients, data on their clinicopathological characteristics and clinical courses between 1990 and 2004 were retrospectively collected, and their tumor BRAF mutation status was determined [39].
  • One main focus of this multicenter study is the evaluation of the mutation spectrum and mutation frequencies in a large HNPCC cohort in Germany; 1,721 unrelated patients, mainly of German descent, who met the Bethesda criteria were included in the study [40].

Analytical, diagnostic and therapeutic context of Multicenter Studies


  1. Six-year follow-up of the Norwegian multicenter study on timolol after myocardial infarction. Bellin, E.Y. N. Engl. J. Med. (1986) [Pubmed]
  2. A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. North American Crohn's Study Group Investigators. Feagan, B.G., Fedorak, R.N., Irvine, E.J., Wild, G., Sutherland, L., Steinhart, A.H., Greenberg, G.R., Koval, J., Wong, C.J., Hopkins, M., Hanauer, S.B., McDonald, J.W. N. Engl. J. Med. (2000) [Pubmed]
  3. A comparison of standard-dose and high-dose epinephrine in cardiac arrest outside the hospital. The Multicenter High-Dose Epinephrine Study Group. Brown, C.G., Martin, D.R., Pepe, P.E., Stueven, H., Cummins, R.O., Gonzalez, E., Jastremski, M. N. Engl. J. Med. (1992) [Pubmed]
  4. Ceftriaxone compared with doxycycline for the treatment of acute disseminated Lyme disease. Dattwyler, R.J., Luft, B.J., Kunkel, M.J., Finkel, M.F., Wormser, G.P., Rush, T.J., Grunwaldt, E., Agger, W.A., Franklin, M., Oswald, D., Cockey, L., Maladorno, D. N. Engl. J. Med. (1997) [Pubmed]
  5. 6-month efficacy, tolerance, and acceptability of a short regimen of oral zidovudine to reduce vertical transmission of HIV in breastfed children in Côte d'Ivoire and Burkina Faso: a double-blind placebo-controlled multicentre trial. DITRAME Study Group. DIminution de la Transmission Mère-Enfant. Dabis, F., Msellati, P., Meda, N., Welffens-Ekra, C., You, B., Manigart, O., Leroy, V., Simonon, A., Cartoux, M., Combe, P., Ouangré, A., Ramon, R., Ky-Zerbo, O., Montcho, C., Salamon, R., Rouzioux, C., Van de Perre, P., Mandelbrot, L. Lancet (1999) [Pubmed]
  6. Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: an 18-month randomised, double-blind, placebo-controlled study. Van Gool, W.A., Weinstein, H.C., Scheltens, P., Walstra, G.J., Scheltens, P.K. Lancet (2001) [Pubmed]
  7. Clinical features of bipolar depression versus major depressive disorder in large multicenter trials. Perlis, R.H., Brown, E., Baker, R.W., Nierenberg, A.A. The American journal of psychiatry. (2006) [Pubmed]
  8. The clinical efficacy of citalopram in treatment of emotional disturbances in dementia disorders. A Nordic multicentre study. Nyth, A.L., Gottfries, C.G. The British journal of psychiatry : the journal of mental science. (1990) [Pubmed]
  9. Efficacy of the novel anxiolytic pregabalin in social anxiety disorder: a placebo-controlled, multicenter study. Pande, A.C., Feltner, D.E., Jefferson, J.W., Davidson, J.R., Pollack, M., Stein, M.B., Lydiard, R.B., Futterer, R., Robinson, P., Slomkowski, M., DuBoff, E., Phelps, M., Janney, C.A., Werth, J.L. Journal of clinical psychopharmacology. (2004) [Pubmed]
  10. Placebo-controlled, multicenter study of sertraline treatment for obsessive-compulsive disorder. Kronig, M.H., Apter, J., Asnis, G., Bystritsky, A., Curtis, G., Ferguson, J., Landbloom, R., Munjack, D., Riesenberg, R., Robinson, D., Roy-Byrne, P., Phillips, K., Du Pont, I.J. Journal of clinical psychopharmacology. (1999) [Pubmed]
  11. Fomepizole for the treatment of methanol poisoning. Brent, J., McMartin, K., Phillips, S., Aaron, C., Kulig, K. N. Engl. J. Med. (2001) [Pubmed]
  12. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). Smilkstein, M.J., Knapp, G.L., Kulig, K.W., Rumack, B.H. N. Engl. J. Med. (1988) [Pubmed]
  13. Transplantation. Hardy, M.A., Sung, R.S. JAMA (1995) [Pubmed]
  14. Transcervical balloon tuboplasty. A multicenter study. Confino, E., Tur-Kaspa, I., DeCherney, A., Corfman, R., Coulam, C., Robinson, E., Haas, G., Katz, E., Vermesh, M., Gleicher, N. JAMA (1990) [Pubmed]
  15. Antihypertensive treatment with metoprolol or hydrochlorothiazide in patients aged 60 to 75 years. Report from a double-blind international multicenter study. Wikstrand, J., Westergren, G., Berglund, G., Bracchetti, D., Van Couter, A., Feldstein, C.A., Ming, K.S., Kuramoto, K., Landahl, S., Meaney, E. JAMA (1986) [Pubmed]
  16. Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators. Feagan, B.G., Rochon, J., Fedorak, R.N., Irvine, E.J., Wild, G., Sutherland, L., Steinhart, A.H., Greenberg, G.R., Gillies, R., Hopkins, M. N. Engl. J. Med. (1995) [Pubmed]
  17. Effectiveness of low-dose heparin in prevention of myocardial reinfarction. Neri Serneri, G.G., Rovelli, F., Gensini, G.F., Pirelli, S., Carnovali, M., Fortini, A. Lancet (1987) [Pubmed]
  18. Platinum-based and non-platinum-based chemotherapy in advanced non-small-cell lung cancer: a randomised multicentre trial. Georgoulias, V., Papadakis, E., Alexopoulos, A., Tsiafaki, X., Rapti, A., Veslemes, M., Palamidas, P., Vlachonikolis, I. Lancet (2001) [Pubmed]
  19. Mitoxantrone in progressive multiple sclerosis: a placebo-controlled, double-blind, randomised, multicentre trial. Hartung, H.P., Gonsette, R., König, N., Kwiecinski, H., Guseo, A., Morrissey, S.P., Krapf, H., Zwingers, T. Lancet (2002) [Pubmed]
  20. Randomised, placebo-controlled multicentre trial of clodronate in multiple myeloma. Finnish Leukaemia Group. Lahtinen, R., Laakso, M., Palva, I., Virkkunen, P., Elomaa, I. Lancet (1992) [Pubmed]
  21. Prognostic importance of preoperative CA-125 in International Federation of Gynecology and Obstetrics stage I epithelial ovarian cancer: an Australian multicenter study. Paramasivam, S., Tripcony, L., Crandon, A., Quinn, M., Hammond, I., Marsden, D., Proietto, A., Davy, M., Carter, J., Nicklin, J., Perrin, L., Obermair, A. J. Clin. Oncol. (2005) [Pubmed]
  22. Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course. Squitieri, F., Gellera, C., Cannella, M., Mariotti, C., Cislaghi, G., Rubinsztein, D.C., Almqvist, E.W., Turner, D., Bachoud-Lévi, A.C., Simpson, S.A., Delatycki, M., Maglione, V., Hayden, M.R., Donato, S.D. Brain (2003) [Pubmed]
  23. A single dose tinidazole and doxycycline prophylaxis in elective surgery of colon and rectum. A prospective controlled clinical multicenter study. Giercksky, K.E., Danielsen, S., Garberg, O., Grüner, O.P., Holter, O., Johnson, J.A., Nygaard, K., Ofstad, E., Stadaas, J., Viddal, K.O. Ann. Surg. (1982) [Pubmed]
  24. RS-61443 (mycophenolate mofetil). A multicenter study for refractory kidney transplant rejection. Sollinger, H.W., Belzer, F.O., Deierhoi, M.H., Diethelm, A.G., Gonwa, T.A., Kauffman, R.S., Klintmalm, G.B., McDiarmid, S.V., Roberts, J., Rosenthal, J.T. Ann. Surg. (1992) [Pubmed]
  25. Factors influencing outcome of treatment with zidovudine of patients with AIDS in Australia. The Australian Zidovudine Study Group. Swanson, C.E., Cooper, D.A. AIDS (1990) [Pubmed]
  26. Placebo-controlled phase III trial of lenograstim in bone-marrow transplantation. Gisselbrecht, C., Prentice, H.G., Bacigalupo, A., Biron, P., Milpied, N., Rubie, H., Cunningham, D., Legros, M., Pico, J.L., Linch, D.C. Lancet (1994) [Pubmed]
  27. Concomitant granulocyte colony-stimulating factor and induction chemoradiotherapy in adult acute lymphoblastic leukemia: a randomized phase III trial. Ottmann, O.G., Hoelzer, D., Gracien, E., Ganser, A., Kelly, K., Reutzel, R., Lipp, T., Busch, F.W., Schwonzen, M., Heil, G. Blood (1995) [Pubmed]
  28. A multiparameter analysis of sickle erythrocytes in patients undergoing hydroxyurea therapy. Bridges, K.R., Barabino, G.D., Brugnara, C., Cho, M.R., Christoph, G.W., Dover, G., Ewenstein, B.M., Golan, D.E., Guttmann, C.R., Hofrichter, J., Mulkern, R.V., Zhang, B., Eaton, W.A. Blood (1996) [Pubmed]
  29. Efficacy and safety of alendronate for the treatment of osteoporosis in diffuse connective tissue diseases in children: a prospective multicenter study. Bianchi, M.L., Cimaz, R., Bardare, M., Zulian, F., Lepore, L., Boncompagni, A., Galbiati, E., Corona, F., Luisetto, G., Giuntini, D., Picco, P., Brandi, M.L., Falcini, F. Arthritis Rheum. (2000) [Pubmed]
  30. Randomized double-blind trial of high- and low-dose fleroxacin versus norfloxacin for complicated urinary tract infection. Pittman, W., Moon, J.O., Hamrick, L.C., Cox, C.E., Clark, J., Childs, S., Pizzuti, D., Fredericks, J., St Clair, P. Am. J. Med. (1993) [Pubmed]
  31. Disulfiram treatment of alcoholism. A Veterans Administration cooperative study. Fuller, R.K., Branchey, L., Brightwell, D.R., Derman, R.M., Emrick, C.D., Iber, F.L., James, K.E., Lacoursiere, R.B., Lee, K.K., Lowenstam, I. JAMA (1986) [Pubmed]
  32. Prevention of postoperative thromboembolism by dextran 40, low doses of heparin, or xantinol nicotinate. Gruber, U.F., Duckert, F., Fridrich, R., Torhorst, J., Rem, J. Lancet (1977) [Pubmed]
  33. Cyclosporin in cadaveric renal transplantation: 5-year follow-up of a multicentre trial. Calne, R.Y. Lancet (1987) [Pubmed]
  34. Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study. The Rapamune US Study Group. Kahan, B.D. Lancet (2000) [Pubmed]
  35. Prophylaxis of postoperative relapse in Crohn's disease with mesalamine: European Cooperative Crohn's Disease Study VI. Lochs, H., Mayer, M., Fleig, W.E., Mortensen, P.B., Bauer, P., Genser, D., Petritsch, W., Raithel, M., Hoffmann, R., Gross, V., Plauth, M., Staun, M., Nesje, L.B. Gastroenterology (2000) [Pubmed]
  36. Prevalence and evolutionary origins of the del(GJB6-D13S1830) mutation in the DFNB1 locus in hearing-impaired subjects: a multicenter study. Del Castillo, I., Moreno-Pelayo, M.A., Del Castillo, F.J., Brownstein, Z., Marlin, S., Adina, Q., Cockburn, D.J., Pandya, A., Siemering, K.R., Chamberlin, G.P., Ballana, E., Wuyts, W., Maciel-Guerra, A.T., Alvarez, A., Villamar, M., Shohat, M., Abeliovich, D., Dahl, H.H., Estivill, X., Gasparini, P., Hutchin, T., Nance, W.E., Sartorato, E.L., Smith, R.J., Van Camp, G., Avraham, K.B., Petit, C., Moreno, F. Am. J. Hum. Genet. (2003) [Pubmed]
  37. Human papillomavirus type 16 and TP53 mutation in oral cancer: matched analysis of the IARC multicenter study. Dai, M., Clifford, G.M., le Calvez, F., Castellsagué, X., Snijders, P.J., Pawlita, M., Herrero, R., Hainaut, P., Franceschi, S. Cancer Res. (2004) [Pubmed]
  38. Tenidap in rheumatoid arthritis. A 24-week double-blind comparison with hydroxychloroquine-plus-piroxicam, and piroxicam alone. Blackburn, W.D., Prupas, H.M., Silverfield, J.C., Poiley, J.E., Caldwell, J.R., Collins, R.L., Miller, M.J., Sikes, D.H., Kaplan, H., Fleischmann, R. Arthritis Rheum. (1995) [Pubmed]
  39. BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer. Xing, M., Westra, W.H., Tufano, R.P., Cohen, Y., Rosenbaum, E., Rhoden, K.J., Carson, K.A., Vasko, V., Larin, A., Tallini, G., Tolaney, S., Holt, E.H., Hui, P., Umbricht, C.B., Basaria, S., Ewertz, M., Tufaro, A.P., Califano, J.A., Ringel, M.D., Zeiger, M.A., Sidransky, D., Ladenson, P.W. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  40. Spectrum and frequencies of mutations in MSH2 and MLH1 identified in 1,721 German families suspected of hereditary nonpolyposis colorectal cancer. Mangold, E., Pagenstecher, C., Friedl, W., Mathiak, M., Buettner, R., Engel, C., Loeffler, M., Holinski-Feder, E., Müller-Koch, Y., Keller, G., Schackert, H.K., Krüger, S., Goecke, T., Moeslein, G., Kloor, M., Gebert, J., Kunstmann, E., Schulmann, K., Rüschoff, J., Propping, P. Int. J. Cancer (2005) [Pubmed]
  41. Low molecular weight heparin in prevention of restenosis after angioplasty. Results of Enoxaparin Restenosis (ERA) Trial. Faxon, D.P., Spiro, T.E., Minor, S., Coté, G., Douglas, J., Gottlieb, R., Califf, R., Dorosti, K., Topol, E., Gordon, J.B. Circulation (1994) [Pubmed]
  42. Effect of human recombinant erythropoietin on reduction of homologous blood transfusion in open-heart surgery. A Japanese Multicenter study. Kyo, S., Omoto, R., Hirashima, K., Eguchi, S., Fujita, T. Circulation (1992) [Pubmed]
  43. Preoperative uracil, tegafur, and concomitant radiotherapy in operable rectal cancer: a phase II multicenter study with 3 years' follow-Up. Fernández-Martos, C., Aparicio, J., Bosch, C., Torregrosa, M., Campos, J.M., Garcera, S., Vicent, J.M., Maestu, I., Climent, M.A., Mengual, J.L., Tormo, A., Hernandez, A., Estevan, R., Richart, J.M., Viciano, V., Uribe, N., Campos, J., Puchades, R., Arlandis, F., Almenar, D. J. Clin. Oncol. (2004) [Pubmed]
  44. Abbott monoclonal enzyme immunoassay measurement of estrogen receptors in human breast cancer: a European multicenter study. Leclercq, G., Bojar, H., Goussard, J., Nicholson, R.I., Pichon, M.F., Piffanelli, A., Pousette, A., Thorpe, S., Lonsdorfer, M. Cancer Res. (1986) [Pubmed]
  45. Radioimmunoscintigraphy of recurrent, metastatic, or occult colorectal cancer with technetium 99m-labeled totally human monoclonal antibody 88BV59: results of pivotal, phase III multicenter studies. Serafini, A.N., Klein, J.L., Wolff, B.G., Baum, R., Chetanneau, A., Pecking, A., Fischman, A.J., Hoover, H.C., Wynant, G.E., Subramanian, R., Goroff, D.K., Hanna, M.G. J. Clin. Oncol. (1998) [Pubmed]
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