Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL328492 3-[7-[3-[2- (cyclopropylmethyl)-3- methoxy-4...

Synonyms: ACMC-1C1U2, AG-D-81905, SureCN1890696, CHEBI:244423, SC-51146, ...

Tsai, B.S. et al.

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High impact information on SC-51146

PMN chemotaxis studies and Scatchard analyses of [3H]LTB4 binding in PMN membranes indicated that SC-51146 acted as a competitive antagonist [1].
The IC50 value of SC-51146 for the inhibition of PMN chemotaxis induced by 30 nM LTB4 was 38 +/- 12 nM [1].
SC-51146 had little activity on ram seminal vesicle cyclooxygenase, and no activity on porcine pancreatic phospholipase A2 [1].

References

The in vitro pharmacology of SC-51146: a potent antagonist of leukotriene B4 receptors. Tsai, B.S., Keith, R.H., Villani-Price, D., Kachur, J.F., Yang, D.C., Djuric, S.W., Yu, S. J. Pharmacol. Exp. Ther. (1994) [Pubmed]

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