Gene Review:
PTGS1 - prostaglandin-endoperoxide synthase 1...
Homo sapiens
Synonyms:
COX-1, COX1, COX3, Cyclooxygenase-1, PCOX1, ...
Masini,
Maggiano,
Souza,
Einspahr,
Meyermann,
Noske,
Catani,
Patrono,
Bekure-Nemariam,
Dietel,
Martínez,
Bovill,
Yochim,
Sibert,
Botting,
Mulichak,
Cianchi,
Duffy,
Müller,
Danenberg,
Zauli,
Smith,
Guski,
Hasstedt,
Byrne,
Cortesini,
Weichert,
Yasui,
Trautmann,
Valliere,
Morgalla,
Bigler,
Denkert,
Dozier,
Bhattacharyya,
Messerini,
Alberts,
Shewmake,
Wang,
Callas,
Danenberg,
Ciabattoni,
Garavito,
Fantappiè,
Goode,
Scott,
Boddi,
Hla,
Mazzanti,
Cryer,
Deininger,
Ulrich,
Melloni,
Garavito,
Guidotti,
Niesporek,
Sardi,
Baroni,
DeWitt,
Long,
Cabrera,
Vannacci,
Scollard,
Simmons,
Schluesener,
Sparks,
Levine,
Ranelletti,
Kristiansen,
Hwang,
Krouse,
Bechi,
Beer,
Potter,
Winzer,
Wu,
Spechler,
Hauptmann,
Rocca,
Whitton,
Secchiero,
- Polymorphisms in PTGS1 (=COX-1) and risk of colorectal polyps. Ulrich, C.M., Bigler, J., Sparks, R., Whitton, J., Sibert, J.G., Goode, E.L., Yasui, Y., Potter, J.D. Cancer Epidemiol. Biomarkers Prev. (2004)
- Characterization of the human prostaglandin H synthase 1 gene (PTGS1): exclusion by genetic linkage analysis as a second modifier gene in familial thrombosis. Scott, B.T., Hasstedt, S.J., Bovill, E.G., Callas, P.W., Valliere, J.E., Wang, L., Wu, K.K., Long, G.L. Blood Coagul. Fibrinolysis (2002)
- Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Tsujii, M., Kawano, S., Tsuji, S., Sawaoka, H., Hori, M., DuBois, R.N. Cell (1998)
- Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. Hwang, D., Scollard, D., Byrne, J., Levine, E. J. Natl. Cancer Inst. (1998)
- Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. Wilborn, J., Crofford, L.J., Burdick, M.D., Kunkel, S.L., Strieter, R.M., Peters-Golden, M. J. Clin. Invest. (1995)
- Alternative splicing of cyclooxygenase-1 gene: altered expression in leucocytes from patients with bronchial asthma and association with aspirin-induced 15-HETE release. Kowalski, M.L., Borowiec, M., Kurowski, M., Pawliczak, R. Allergy (2007)
- Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Simmons, D.L., Botting, R.M., Hla, T. Pharmacol. Rev. (2004)
- From epidemiology to therapeutic trials with anti-inflammatory drugs in Alzheimer's disease: the role of NSAIDs and cyclooxygenase in beta-amyloidosis and clinical dementia. Pasinetti, G.M. J. Alzheimers Dis. (2002)
- Cyclooxygenase-1 and -2 in brains of patients who died with sporadic Creutzfeldt-Jakob disease. Deininger, M.H., Bekure-Nemariam, K., Trautmann, K., Morgalla, M., Meyermann, R., Schluesener, H.J. J. Mol. Neurosci. (2003)
- Pharmacological and histopathological characterization of a hyperalgesia model induced by freeze lesion. Schmidtko, A., Burian, M., Altis, K., Hardt, K., Angioni, C., Schmidt, R., Podda, M., Geisslinger, G. Pain (2007)
- Theoretical studies on the inhibition mechanism of cyclooxygenase-2. Is there a unique recognition site? Soliva, R., Almansa, C., Kalko, S.G., Luque, F.J., Orozco, M. J. Med. Chem. (2003)
- Cyclooxygenases: structural, cellular, and molecular biology. Smith, W.L., DeWitt, D.L., Garavito, R.M. Annu. Rev. Biochem. (2000)
- Prostanoid receptors: structures, properties, and functions. Narumiya, S., Sugimoto, Y., Ushikubi, F. Physiol. Rev. (1999)
- Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin e receptors, and angiogenic factors by cyclooxygenase-1. Sales, K.J., Katz, A.A., Howard, B., Soeters, R.P., Millar, R.P., Jabbour, H.N., Soeters, R.P. Cancer Res. (2002)
- Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells. Souza, R.F., Shewmake, K., Beer, D.G., Cryer, B., Spechler, S.J. Cancer Res. (2000)
- Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines. Soriano, A.F., Helfrich, B., Chan, D.C., Heasley, L.E., Bunn, P.A., Chou, T.C. Cancer Res. (1999)
- Association between Cyclooxygenase expression and colorectal adenoma characteristics. Einspahr, J.G., Krouse, R.S., Yochim, J.M., Danenberg, P.V., Danenberg, K.D., Bhattacharyya, A.K., Martínez, M.E., Alberts, D.S. Cancer Res. (2003)
- EBV suppresses prostaglandin E2 biosynthesis in human monocytes. Savard, M., Bélanger, C., Tremblay, M.J., Dumais, N., Flamand, L., Borgeat, P., Gosselin, J. J. Immunol. (2000)
- Prostaglandin H2 synthase-1 and -2 expression in guinea pig gestational tissues during late pregnancy and parturition. Welsh, T., Mitchell, C.M., Walters, W.A., Mesiano, S., Zakar, T. J. Physiol. (Lond.) (2005)
- Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2. Kosaka, T., Miyata, A., Ihara, H., Hara, S., Sugimoto, T., Takeda, O., Takahashi, E., Tanabe, T. Eur. J. Biochem. (1994)
- Prostaglandin-endoperoxide synthase (PTGS1 and PTGS2) expression and prostaglandin production by normal monkey ovarian surface epithelium. Cabrera, R.A., Dozier, B.L., Duffy, D.M. Fertil. Steril. (2006)
- Genetic model of selective COX2 inhibition reveals novel heterodimer signaling. Yu, Y., Fan, J., Chen, X.S., Wang, D., Klein-Szanto, A.J., Campbell, R.L., FitzGerald, G.A., Funk, C.D. Nat. Med. (2006)
- Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors. DuBois, R.N., Radhika, A., Reddy, B.S., Entingh, A.J. Gastroenterology (1996)
- Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets. Rocca, B., Secchiero, P., Ciabattoni, G., Ranelletti, F.O., Catani, L., Guidotti, L., Melloni, E., Maggiano, N., Zauli, G., Patrono, C. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa. Fiorucci, S., Santucci, L., Wallace, J.L., Sardina, M., Romano, M., del Soldato, P., Morelli, A. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1). Lee, C.R., Bottone, F.G., Krahn, J.M., Li, L., Mohrenweiser, H.W., Cook, M.E., Petrovich, R.M., Bell, D.A., Eling, T.E., Zeldin, D.C. Pharmacogenet. Genomics (2007)
- Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides. Harman, C.A., Turman, M.V., Kozak, K.R., Marnett, L.J., Smith, W.L., Garavito, R.M. J. Biol. Chem. (2007)
- Partnering between monomers of cyclooxygenase-2 homodimers. Yuan, C., Rieke, C.J., Rimon, G., Wingerd, B.A., Smith, W.L. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Correlation of expression of cyclooxygenase-2, vascular endothelial growth factor, and peroxisome proliferator-activated receptor delta with head and neck squamous cell carcinoma. Jaeckel, E.C., Raja, S., Tan, J., Das, S.K., Dey, S.K., Girod, D.A., Tsue, T.T., Sanford, T.R. Arch. Otolaryngol. Head Neck Surg. (2001)
- The structure of mammalian cyclooxygenases. Garavito, R.M., Mulichak, A.M. Annual review of biophysics and biomolecular structure. (2003)
- Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma. Denkert, C., Weichert, W., Winzer, K.J., Müller, B.M., Noske, A., Niesporek, S., Kristiansen, G., Guski, H., Dietel, M., Hauptmann, S. Clin. Cancer Res. (2004)
- B cell differentiation and interleukin 2 (IL2): corticosteroids interact with monocytes to enhance the effect of IL2. Emilie, D., Karray, S., Crevon, M.C., Vazquez, A., Galanaud, P. Eur. J. Immunol. (1987)
- Mutational analysis of the role of the distal histidine and glutamine residues of prostaglandin-endoperoxide synthase-2 in peroxidase catalysis, hydroperoxide reduction, and cyclooxygenase activation. Landino, L.M., Crews, B.C., Gierse, J.K., Hauser, S.D., Marnett, L.J. J. Biol. Chem. (1997)
- Role of Asn-382 and Thr-383 in activation and inactivation of human prostaglandin H synthase cyclooxygenase catalysis. Bambai, B., Rogge, C.E., Stec, B., Kulmacz, R.J. J. Biol. Chem. (2004)
- Cyclooxygenase inhibitors suppress aromatase expression and activity in breast cancer cells. Díaz-Cruz, E.S., Shapiro, C.L., Brueggemeier, R.W. J. Clin. Endocrinol. Metab. (2005)
- Vascular endothelial growth factor upregulates constitutive cyclooxygenase 1 in primary bovine and human endothelial cells. Bryant, C.E., Appleton, I., Mitchell, J.A. Life Sci. (1998)
- COX-1 and COX-2 contributions to basal and IL-1 beta-stimulated prostanoid synthesis in human neonatal cerebral microvascular endothelial cells. Parfenova, H., Levine, V., Gunther, W.M., Pourcyrous, M., Leffler, C.W. Pediatr. Res. (2002)
- Interferon-gamma and interleukin 4 inhibit interleukin 1beta-induced delayed prostaglandin E(2)generation through suppression of cyclooxygenase-2 expression in human fibroblasts. Hayashi, Y., Kobayashi, M., Kuwata, H., Atsumi, G., Deguchi, K., Feng Wei, X., Kudo, I., Hasegawa, K. Cytokine (2000)
- Expression of 5-lipoxygenase and cyclooxygenase pathway enzymes in nasal polyps of patients with aspirin-intolerant asthma. Adamjee, J., Suh, Y.J., Park, H.S., Choi, J.H., Penrose, J.F., Lam, B.K., Austen, K.F., Cazaly, A.M., Wilson, S.J., Sampson, A.P. J. Pathol. (2006)
- Prostaglandin e synthase, a terminal enzyme for prostaglandin E2 biosynthesis. Kudo, I., Murakami, M. J. Biochem. Mol. Biol. (2005)
- Regulation of cytosolic phospholipase A2, cyclooxygenase-1 and -2 expression by PMA, TNFalpha, LPS and M-CSF in human monocytes and macrophages. Jiang, Y.J., Lu, B., Choy, P.C., Hatch, G.M. Mol. Cell. Biochem. (2003)
- Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer. Cianchi, F., Cortesini, C., Bechi, P., Fantappiè, O., Messerini, L., Vannacci, A., Sardi, I., Baroni, G., Boddi, V., Mazzanti, R., Masini, E. Gastroenterology (2001)
- Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Sano, H., Kawahito, Y., Wilder, R.L., Hashiramoto, A., Mukai, S., Asai, K., Kimura, S., Kato, H., Kondo, M., Hla, T. Cancer Res. (1995)