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Chemical Compound Review

LS-191177     4-[4-[2-[[3-(2-aminoethyl)- 1H-indol-5...

Synonyms: F-11356, AC1L53VA, F 11356, 170911-68-9, Donitriptan hydrochloride, ...
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High impact information on Donitriptan

  • In isolated guinea pig trigeminal ganglion neurons, F 11356 was more potent (pD2 = 7.3 versus 6.7) and induced greater increases in outward hyperpolarizing Ca2+-dependent K+ current than sumatriptan [1].
  • Decreases in carotid blood flow were observed in conscious dogs from 0.63 mg/kg oral F 11356 in the absence of changes in heart rate or behavior [1].


  1. F 11356, a novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine. John, G.W., Pauwels, P.J., Perez, M., Halazy, S., Le Grand, B., Verscheure, Y., Valentin, J.P., Palmier, C., Wurch, T., Chopin, P., Marien, M., Kleven, M.S., Koek, W., Assie, M.B., Carilla-Durand, E., Tarayre, J.P., Colpaert, F.C. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
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