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Chemical Compound Review

Donitriptan     4-[4-[2-[[3-(2-aminoethyl)- 1H-indol-5...

Synonyms: CHEMBL1742428, SureCN1388876, LS-193882, AC1L53VE, L000746, ...
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Disease relevance of Donitriptan


High impact information on Donitriptan


Biological context of Donitriptan


Anatomical context of Donitriptan

  • These results show that donitriptan selectively constricts arteriovenous anastomoses via 5-HT1B receptor activation [5].
  • Donitriptan did not decrease vascular conductances in or blood flow to a number of organs, including the heart and kidneys; in fact, vascular conductances in the skin, brain and skeletal muscles increased [5].
  • Furthermore, using the concentration-response curves in the middle meningeal artery, we predicted the plasma concentration needed for the therapeutic effect of donitriptan [2].

Gene context of Donitriptan


  1. An in vivo rat model to study calcitonin gene related peptide release following activation of the trigeminal vascular system. Limmroth, V., Katsarava, Z., Liedert, B., Guehring, H., Schmitz, K., Diener, H.C., Michel, M.C. Pain (2001) [Pubmed]
  2. Comparison of contractile responses to donitriptan and sumatriptan in the human middle meningeal and coronary arteries. van den Broek, R.W., MaassenVanDenBrink, A., Mulder, P.G., Bogers, A.J., Avezaat, C.J., John, G.W., Saxena, P.R. Eur. J. Pharmacol. (2002) [Pubmed]
  3. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Muñoz-Islas, E., Gupta, S., Jiménez-Mena, L.R., Lozano-Cuenca, J., Sánchez-López, A., Centurión, D., Mehrotra, S., MaassenVanDenBrink, A., Villalón, C.M. Br. J. Pharmacol. (2006) [Pubmed]
  4. Donitriptan decreases jugular venous oxygen saturation in rats in the absence of cranial vasoconstriction: an overlooked mechanism of antimigraine action? Létienne, R., Blanchet, J.C., Sole, E., John, G.W., Le Grand, B. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  5. Effects of donitriptan on carotid haemodynamics and cardiac output distribution in anaesthetized pigs. Tom, B., De Vries, P., Heiligers, J.P., Willems, E.W., Kapoor, K., John, G.W., Saxena, P.R. Cephalalgia : an international journal of headache. (2002) [Pubmed]
  6. Donitriptan selectively decreases jugular venous oxygen saturation in the anesthetized pig: further insights into its mechanism of action relevant to headache relief. Letienne, R., Verscheure, Y., Perez, M., Le Grand, B., Colpaert, F.C., John, G.W. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  7. Donitriptan (Pierre Fabre). Dukat, M. Current opinion in investigational drugs (London, England : 2000) (2001) [Pubmed]
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