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Chemical Compound Review:

SureCN975675 3,4-dihydroxy-5-methoxy- benzoic acid

Synonyms: AG-F-39025, CHEBI:28647, GEO-01103, AC-6626, AC1L2EYH, ...

Hara, H. et al., Abe, T. et al., Kasai, D. et al., Masai, E. et al.

Masai, Sasaki, Minakawa, Abe, Sonoki, Miyauchi, Katayama, Fukuda,

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Disease relevance of C05616

The cell extract of E. coli carrying desA converted syringate to 3MGA only when H(4)folate was added to the reaction mixture [1].
Characterization of the 3-O-methylgallate dioxygenase gene and evidence of multiple 3-O-methylgallate catabolic pathways in Sphingomonas paucimobilis SYK-6 [2].

High impact information on C05616

PCA is further degraded via the PCA 4,5-cleavage pathway, while 3MGA is degraded through multiple pathways in which PCA 4,5-dioxygenase (LigAB), 3MGA 3,4-dioxygenase (DesZ), and an unidentified 3MGA O-demethylase and gallate dioxygenase are participants [3].

Biological context of C05616

These results indicated that syringate is converted into OMA via 3MGA, and it enters the PCA 4,5-cleavage pathway [4].

Associations of C05616 with other chemical compounds

Vanillate and syringate are degraded by the O-demethylase and converted into protocatechuate (PCA) and 3-O-methylgallate (3MGA), respectively [4].

References

A novel tetrahydrofolate-dependent O-demethylase gene is essential for growth of Sphingomonas paucimobilis SYK-6 with syringate. Masai, E., Sasaki, M., Minakawa, Y., Abe, T., Sonoki, T., Miyauchi, K., Katayama, Y., Fukuda, M. J. Bacteriol. (2004) [Pubmed]
Characterization of the 3-O-methylgallate dioxygenase gene and evidence of multiple 3-O-methylgallate catabolic pathways in Sphingomonas paucimobilis SYK-6. Kasai, D., Masai, E., Miyauchi, K., Katayama, Y., Fukuda, M. J. Bacteriol. (2004) [Pubmed]
A tetrahydrofolate-dependent O-demethylase, LigM, is crucial for catabolism of vanillate and syringate in Sphingomonas paucimobilis SYK-6. Abe, T., Masai, E., Miyauchi, K., Katayama, Y., Fukuda, M. J. Bacteriol. (2005) [Pubmed]
The 4-oxalomesaconate hydratase gene, involved in the protocatechuate 4,5-cleavage pathway, is essential to vanillate and syringate degradation in Sphingomonas paucimobilis SYK-6. Hara, H., Masai, E., Katayama, Y., Fukuda, M. J. Bacteriol. (2000) [Pubmed]

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