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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

Pentanol-2     pentan-2-ol

Synonyms: PubChem6719, Pentan-2-ol, Pentanol, sec-, CHEMBL45065, P8017_ALDRICH, ...
 
 
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High impact information on pentan-2-ol

  • The kinetics of the production of the two major microsomal metabolites has been determined as Km = 56 +/- 19 microM and Vmax = 126 +/- 21 pmol/min/mg microsomal protein for the 2-pentanol analog, and Km = 28 +/- 0.28 microM and Vmax = 195 +/- 2.4 pmol/min/mg microsomal protein for the 3-pentanol analog [1].
  • Enzymatic resolution of racemic 2-pentanol and 2-heptanol by lipase B from Candida antarctica was demonstrated [2].
  • We applied enantiomers of two chiral anesthetic alcohols (2-butanol and 2-pentanol) that are enantioselective for the minimum alveolar concentration (MAC) preventing movement in 50% of animals and one (2-hexanol) that was not to frog oocytes [3].
  • The method was validated according to the Washington Consensus Conference on the Validation of Analytical Methods. It involved extraction of the plasma with n-hexane containing 2-pentanol, followed by reversed-phase HPLC using a Partisil ODS2 10 microns column and UV detection at 265 nm [4].

References

  1. Hydroxylation of pentamidine by rat liver microsomes. Berger, B.J., Reddy, V.V., Le, S.T., Lombardy, R.J., Hall, J.E., Tidwell, R.R. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  2. Microbial/enzymatic synthesis of chiral drug intermediates. Patel, R.N. Adv. Appl. Microbiol. (2000) [Pubmed]
  3. Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomers. Brosnan, R., Gong, D., Cotten, J., Keshavaprasad, B., Yost, C.S., Eger, E.I., Sonner, J.M. Anesth. Analg. (2006) [Pubmed]
  4. Determination of trimebutine and desmethyl-trimebutine in human plasma by HPLC. Lavit, M., Saivin, S., Boudra, H., Michel, F., Martin, A., Cahiez, G., Labaune, J.P., Chomard, J.M., Houin, G. Arzneimittel-Forschung. (2000) [Pubmed]
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