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Chemical Compound Review:

Lefetamine N,N-dimethyl-1,2-diphenyl- ethanamine

Synonyms: CHEMBL2106355, SureCN1650099, NSC-31924, NSC31924, LS-68099, ...

Paroli, E. et al., Mannelli, P. et al., De Montis, M.G. et al., Janiri, L. et al.

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Disease relevance of Lefetamine

In mice lefetamine, at the dose of 50 mg/kg produces motor hyperactivity and at the dose of 60 mg/kg produces analgesia [1].

Psychiatry related information on Lefetamine

Lefetamine was able to relieve opiate withdrawal and did not precipitate withdrawal symptoms in stabilized opiate addicts [2].

High impact information on Lefetamine

Dual effects of lephetamine on spontaneous and evoked neuronal firing in the somatosensory cortex of the rat [3].
Furthermore, experimental results showed that lefetamine induced a naloxone-reversible inhibition of the guinea-pig ileum contractile response to electric field stimulation, and that naloxone pretreatment of mice prevented lefetamine antinociceptive activity in the hot-plate test [4].

References

Opioid activity of lefetamine. De Montis, M.G., Devoto, P., Bucarelli, A., Tagliamonte, A. Pharmacological research communications. (1985) [Pubmed]
Lefetamine: new abuse of an old drug--clinical evaluation of opioid activity. Mannelli, P., Janiri, L., De Marinis, M., Tempesta, E. Drug and alcohol dependence. (1989) [Pubmed]
Dual effects of lephetamine on spontaneous and evoked neuronal firing in the somatosensory cortex of the rat. Janiri, L., Persico, A.M., Tempesta, E. Neuropharmacology (1989) [Pubmed]
Clinical and experimental evidence of an opiate-like activity of lefetamine. Paroli, E., Nencini, P., Moscucci, M. Pharmacological research communications. (1984) [Pubmed]

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