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Chemical Compound Review:

Dichloroethyne 1,2-dichloroethyne

Synonyms: CCRIS 5411, AG-H-01933, HSDB 7200, LS-7321, AC1L2NAQ, ...

Makar, T.K. et al., Kanhai, W. et al., Barret, L. et al., Albee, R.R. et al., Patel, N.J. et al., et al.

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Disease relevance of DICHLOROACETYLENE

Dichloroacetylene causes trigeminal neuropathy in humans and animals [1].
Organ-specific toxicity and carcinogenicity of dichloroethyne is due most likely to the topographical distribution of gamma-glutamyl transpeptidase which is concentrated mainly in the kidney in rats [2].

High impact information on DICHLOROACETYLENE

Glutamine transaminase K appears to be a major cysteine S-conjugate beta-lyase of the brain and may play a role in the neurotoxicity associated with exposure to dichloroacetylene and perhaps to other toxins [3].
Carcinogenicity of dichloroacetylene: an inhalation study [4].
Dichloroacetylene: effects on the rat trigeminal nerve somatosensory evoked potential [5].
Morphometric analysis was used to compare the effects of trichloroethylene (Tri) and dichloroacetylene (Dca) on the fibre parameters of the trigeminal nerve [6].

References

Brain uptake of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine, the glutathione and cysteine S-conjugates of the neurotoxin dichloroacetylene. Patel, N.J., Fullone, J.S., Anders, M.W. Brain Res. Mol. Brain Res. (1993) [Pubmed]
Metabolism of 14C-dichloroethyne in rats. Kanhai, W., Koob, M., Dekant, W., Henschler, D. Xenobiotica (1991) [Pubmed]
Glutamine transaminase K and omega-amidase activities in primary cultures of astrocytes and neurons and in embryonic chick forebrain: marked induction of brain glutamine transaminase K at time of hatching. Makar, T.K., Nedergaard, M., Preuss, A., Hertz, L., Cooper, A.J. J. Neurochem. (1994) [Pubmed]
Carcinogenicity of dichloroacetylene: an inhalation study. Reichert, D., Spengler, U., Romen, W., Henschler, D. Carcinogenesis (1984) [Pubmed]
Dichloroacetylene: effects on the rat trigeminal nerve somatosensory evoked potential. Albee, R.R., Nitschke, K.D., Mattsson, J.L., Stebbins, K.E. Neurotoxicology and teratology. (1997) [Pubmed]
A morphometric evaluation of the effects of trichloroethylene and dichloroacetylene on the rat mental nerve. Preliminary results. Barret, L., Torch, S., Usson, Y., Gonthier, B., Saxod, R. Neurosci. Lett. (1991) [Pubmed]

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