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Chemical Compound Review

Trielina     1,1,2-trichloroethene

Synonyms: Anamenth, Benzinol, Cecolene, Chorylen, Lethurin, ...
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Disease relevance of Ethinyl trichloride


Psychiatry related information on Ethinyl trichloride


High impact information on Ethinyl trichloride


Chemical compound and disease context of Ethinyl trichloride


Biological context of Ethinyl trichloride


Anatomical context of Ethinyl trichloride


Associations of Ethinyl trichloride with other chemical compounds


Gene context of Ethinyl trichloride

  • This contrasts with a recent report of reduced risk of RCC associated with GSTT1 null in a cohort of trichloroethene-exposed workers and suggests that specific chemical exposures alter the effect of GSTT1 on cancer risk [26].
  • Differences in cytochrome P450-catalysed oxidation of benzene, toluene and trichloroethylene (TRI) between male Wistar rats and male B6C3F1 mice were investigated by immunoblot and immunoinhibition assays using monoclonal antibodies (MAbs) to cytochrome P450 (CYP1A1/2, CYP2B1/2, CYP2E1 and CYP2C11/6) [27].
  • Taken collectively, metabolism of trichloroethylene by CYP2E1 is responsible, at least in part, for the CD4+ T cell alterations associated with exposure to this environmental toxicant [28].
  • Exposure to a metabolite of the environmental toxicant, trichloroethylene, attenuates CD4+ T cell activation-induced cell death by metalloproteinase-dependent FasL shedding [29].
  • Although this polymorphism is limited in the case of Japanese as well as other Asian subjects, the inhibitors of ALDH2 activity such as trichloroethylene may produce a false polymorphism of this gene [30].

Analytical, diagnostic and therapeutic context of Ethinyl trichloride


  1. Trichloroethylene exposure and specific somatic mutations in patients with renal cell carcinoma. Brauch, H., Weirich, G., Hornauer, M.A., Störkel, S., Wöhl, T., Brüning, T. J. Natl. Cancer Inst. (1999) [Pubmed]
  2. Chronic dysphagia and trigeminal anesthesia after trichloroethylene exposure. Lawrence, W.H., Partyka, E.K. Ann. Intern. Med. (1981) [Pubmed]
  3. Biodegradation of low-molecular-weight halogenated hydrocarbons by methanotrophic bacteria. Hanson, R.S., Tsien, H.C., Tsuji, K., Brusseau, G.A., Wackett, L.P. FEMS Microbiol. Rev. (1990) [Pubmed]
  4. Functional analyses of Bph-Tod hybrid dioxygenase, which exhibits high degradation activity toward trichloroethylene. Maeda, T., Takahashi, Y., Suenaga, H., Suyama, A., Goto, M., Furukawa, K. J. Biol. Chem. (2001) [Pubmed]
  5. Renal toxicity and carcinogenicity of trichloroethylene: key results, mechanisms, and controversies. Brüning, T., Bolt, H.M. Crit. Rev. Toxicol. (2000) [Pubmed]
  6. Repeated inhalation of toluene by rats performing a signal detection task leads to behavioral tolerance on some performance measures. Oshiro, W.M., Krantz, Q.T., Bushnell, P.J. Neurotoxicology and teratology (2007) [Pubmed]
  7. Mid-frequency hearing loss and reduction of acoustic startle responding in rats following trichloroethylene exposure. Jaspers, R.M., Muijser, H., Lammers, J.H., Kulig, B.M. Neurotoxicology and teratology. (1993) [Pubmed]
  8. Time-dependent effects of trichloroethylene on motor activity in rats. Motohashi, Y., Miyazaki, Y. Chronobiol. Int. (1990) [Pubmed]
  9. Effect of ethanol on the metabolism of trichloroethylene in the perfused rat liver. Watanabe, M., Takano, T., Nakamura, K. J. Toxicol. Environ. Health Part A (1998) [Pubmed]
  10. Setting information priorities for remediation decisions at a contaminated-groundwater site. Ma, H.W., Wu, K.Y., Ton, C.D. Chemosphere (2002) [Pubmed]
  11. Hepatotoxicity of trichloroethylene-carbon tetrachloride mixtures in rats. A possible consequence of the potentiation by trichloroethylene of carbon tetrachloride-induced lipid peroxidation and liver lesions. Pessayre, D., Cobert, B., Descatoire, V., Degott, C., Babany, G., Funck-Brentano, C., Delaforge, M., Larrey, D. Gastroenterology (1982) [Pubmed]
  12. Carcinogens induce reversion of the mouse pink-eyed unstable mutation. Schiestl, R.H., Aubrecht, J., Khogali, F., Carls, N. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  13. An association of human congenital cardiac malformations and drinking water contaminants. Goldberg, S.J., Lebowitz, M.D., Graver, E.J., Hicks, S. J. Am. Coll. Cardiol. (1990) [Pubmed]
  14. Possible involvement of glutathione and p53 in trichloroethylene- and perchloroethylene-induced lipid peroxidation and apoptosis in human lung cancer cells. Chen, S.J., Wang, J.L., Chen, J.H., Huang, R.N. Free Radic. Biol. Med. (2002) [Pubmed]
  15. 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline-induced apoptosis in the human neuroblastoma cell line SK-N-SH. Akundi, R.S., Macho, A., Muñoz, E., Lieb, K., Bringmann, G., Clement, H.W., Hüll, M., Fiebich, B.L. J. Neurochem. (2004) [Pubmed]
  16. Covalent binding of xenobiotics to specific proteins in the liver. Pumford, N.R., Halmes, N.C., Hinson, J.A. Drug Metab. Rev. (1997) [Pubmed]
  17. Constitutive expression of the cloned phenol hydroxylase gene(s) from Alcaligenes eutrophus JMP134 and concomitant trichloroethylene oxidation. Kim, Y., Ayoubi, P., Harker, A.R. Appl. Environ. Microbiol. (1996) [Pubmed]
  18. Cardiac teratogenesis of halogenated hydrocarbon-contaminated drinking water. Dawson, B.V., Johnson, P.D., Goldberg, S.J., Ulreich, J.B. J. Am. Coll. Cardiol. (1993) [Pubmed]
  19. Sex-dependent regulation of hepatic peroxisome proliferation in mice by trichloroethylene via peroxisome proliferator-activated receptor alpha (PPARalpha). Nakajima, T., Kamijo, Y., Usuda, N., Liang, Y., Fukushima, Y., Kametani, K., Gonzalez, F.J., Aoyama, T. Carcinogenesis (2000) [Pubmed]
  20. ras proto-oncogene activation in dichloroacetic acid-, trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice. Anna, C.H., Maronpot, R.R., Pereira, M.A., Foley, J.F., Malarkey, D.E., Anderson, M.W. Carcinogenesis (1994) [Pubmed]
  21. Review of experimental carcinogenesis by compounds related to vinyl chloride. Chu, K.C., Milman, H.A. Environ. Health Perspect. (1981) [Pubmed]
  22. Metabolism of trichloroethylene in isolated hepatocytes, microsomes, and reconstituted enzyme systems containing cytochrome P-450. Miller, R.E., Guengerich, F.P. Cancer Res. (1983) [Pubmed]
  23. Covalent interaction of metabolites of the carcinogen trichloroethylene in rat hepatic microsomes. Van Duuren, B.L., Banerjee, S. Cancer Res. (1976) [Pubmed]
  24. Trapping and identification of the dichloroacetate radical from the reductive dehalogenation of trichloroacetate by mouse and rat liver microsomes. Merdink, J.L., Bull, R.J., Schultz, I.R. Free Radic. Biol. Med. (2000) [Pubmed]
  25. Mechanistic studies of the photocatalytic oxidation of trichloroethylene with visible-light-driven N-doped TiO2 photocatalysts. Joung, S.K., Amemiya, T., Murabayashi, M., Itoh, K. Chemistry (Weinheim an der Bergstrasse, Germany) (2006) [Pubmed]
  26. Glutathione S-transferase M1, T1, and P1 polymorphisms as risk factors for renal cell carcinoma: a case-control study. Sweeney, C., Farrow, D.C., Schwartz, S.M., Eaton, D.L., Checkoway, H., Vaughan, T.L. Cancer Epidemiol. Biomarkers Prev. (2000) [Pubmed]
  27. Cytochrome P450-related differences between rats and mice in the metabolism of benzene, toluene and trichloroethylene in liver microsomes. Nakajima, T., Wang, R.S., Elovaara, E., Park, S.S., Gelboin, H.V., Vainio, H. Biochem. Pharmacol. (1993) [Pubmed]
  28. Inhibition of CYP2E1 reverses CD4+ T-cell alterations in trichloroethylene-treated MRL+/+ mice. Griffin, J.M., Gilbert, K.M., Pumford, N.R. Toxicol. Sci. (2000) [Pubmed]
  29. Exposure to a metabolite of the environmental toxicant, trichloroethylene, attenuates CD4+ T cell activation-induced cell death by metalloproteinase-dependent FasL shedding. Blossom, S.J., Gilbert, K.M. Toxicol. Sci. (2006) [Pubmed]
  30. Polymorphism of drug-metabolizing enzymes in relation to individual susceptibility to industrial chemicals. Nakajima, T., Aoyama, T. Industrial health. (2000) [Pubmed]
  31. Airway injury by trichloroethylene: a scanning electron microscopic study. Forkert, P.G., Troughton, K.M. J. Pathol. (1987) [Pubmed]
  32. Coupling transport and biodegradation of VOCs in surface and subsurface soils. Hunt, J.R., Holden, P.A., Firestone, M.K. Environ. Health Perspect. (1995) [Pubmed]
  33. Cardiac teratogenicity of dichloroethylene in a chick model. Goldberg, S.J., Dawson, B.V., Johnson, P.D., Hoyme, H.E., Ulreich, J.B. Pediatr. Res. (1992) [Pubmed]
  34. Dose-response analyses of the carcinogenic effects of trichloroethylene in experimental animals. Rhomberg, L.R. Environ. Health Perspect. (2000) [Pubmed]
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