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MeSH Review

Trigeminal Nerve

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Disease relevance of Trigeminal Nerve


High impact information on Trigeminal Nerve

  • The LEF-1-deficient mice also lack the mesencephalic nucleus of the trigeminal nerve, the only neural crest-derived neuronal populations [6].
  • Viral transport via the trigeminal nerve was not affected by removal of the olfactory bulb, showing that the surgical procedure was specific for the olfactory pathway [7].
  • Sequential evaluations were made of the morphology and biochemistry of trigeminal nerves from control and ethylnitrosourea (ENU)-exposed rats from 1 day to 6 months of age [8].
  • Similarly, desmosterol increased only slightly in developing normal trigeminal nerve compared to the high levels observed in developing cerebrum [9].
  • Substance P, a potent vasodilating peptide, seems to be released from trigeminal nerve endings in response to nervous stimulation and is involved in the transmission of painful stimuli within the periphery [10].

Chemical compound and disease context of Trigeminal Nerve


Biological context of Trigeminal Nerve


Anatomical context of Trigeminal Nerve


Associations of Trigeminal Nerve with chemical compounds

  • Chronic division of the ipsilateral trigeminal nerve in cats did not modify the magnitude of arteriolar responses to perivascular microapplication of either vasoconstrictor or vasodilator agents, but the duration of vasoconstrictor responses to norepinephrine (0.1 mM) or alkaline solutions (pH 7.6) was significantly increased [26].
  • MRI scan showed a marked reduction in the calibre of the left trigeminal nerve from the nerve root exit zone in the pons to Meckel's cave [27].
  • MRI in the coronal plane under gadolinium enhancement established the diagnosis by visualization of the lower divisions of the trigeminal nerve [28].
  • The authors report two patients with idiopathic trigeminal sensory neuropathy who showed gadolinium enhancement of the cisternal segment of the corresponding trigeminal nerve in cranial MRI [29].
  • Evidence from animal and human studies suggests that sumatriptan constricts dural vessels and inhibits neuropeptide release from trigeminal nerve endings by activating 5-HT1 receptors [30].

Gene context of Trigeminal Nerve


Analytical, diagnostic and therapeutic context of Trigeminal Nerve


  1. The interaction mode of premalignant Schwann and immune effector cells during chemically induced carcinogenesis in the rat peripheral nervous system is strongly influenced by genetic background. Gering, K.M., Marx, J.A., Lennartz, K., Fischer, C., Rajewsky, M.F., Kindler-Röhrborn, A. Cancer Res. (2006) [Pubmed]
  2. Substance P-induced cadherin expression and its signal transduction in a cloned human corneal epithelial cell line. Araki-Sasaki, K., Aizawa, S., Hiramoto, M., Nakamura, M., Iwase, O., Nakata, K., Sasaki, Y., Mano, T., Handa, H., Tano, Y. J. Cell. Physiol. (2000) [Pubmed]
  3. The olfactory nerve and not the trigeminal nerve is the major site of CNS entry for mouse hepatitis virus, strain JHM. Barnett, E.M., Perlman, S. Virology (1993) [Pubmed]
  4. Schmidt-Lanterman's incisures--the principal target of autoimmune attack in demyelinating Guillain-Barré syndrome? Görtzen, A., Schlüter, S., Veh, R.W. J. Neuroimmunol. (1999) [Pubmed]
  5. Aseptic meningitis caused by Teflon implantation for microvascular decompression. Case report. Bobek, M.P., Sagher, O. J. Neurosurg. (1999) [Pubmed]
  6. Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. van Genderen, C., Okamura, R.M., Fariñas, I., Quo, R.G., Parslow, T.G., Bruhn, L., Grosschedl, R. Genes Dev. (1994) [Pubmed]
  7. Effect of olfactory bulb ablation on spread of a neurotropic coronavirus into the mouse brain. Perlman, S., Evans, G., Afifi, A. J. Exp. Med. (1990) [Pubmed]
  8. Sequential development of ethylnitrosourea-induced neurinomas: morphology, biochemistry, and transplantability. Swenberg, J.A., Clendenon, N., Denlinger, R., Gordon, W.A. J. Natl. Cancer Inst. (1975) [Pubmed]
  9. Desmosterol in rat central and peripheral nervous systems during normal and neoplastic growth. Weiss, J.F., Cravioto, H., Ransohoff, J. J. Natl. Cancer Inst. (1975) [Pubmed]
  10. Neurotransmitters and the fifth cranial nerve: is there a relation to the headache phase of migraine? Moskowitz, M.A., Reinhard, J.F., Romero, J., Melamed, E., Pettibone, D.J. Lancet (1979) [Pubmed]
  11. Neonatal capsaicin administration: effects on behavioral development of the rat. Carrillo, P., Manzo, J., Martinez-Gomez, M., Salas, M., Pacheco, P. Pharmacol. Biochem. Behav. (1994) [Pubmed]
  12. Ocular responses to antidromic trigeminal stimulation, intracameral prostaglandin E1 and E2, capsaicin and substance P. Mandahl, A., Bill, A. Acta Physiol. Scand. (1981) [Pubmed]
  13. In the eye (D-Pro2, D-Trp7,9)-SP is a substance P agonist, which modifies the responses to substance P, prostaglandin E1 and antidromic trigeminal nerve stimulation. Mandahl, A., Bill, A. Acta Physiol. Scand. (1983) [Pubmed]
  14. Clinicopathologic variation in raccoons infected with different street rabies virus isolates. Hamir, A.N., Moser, G., Rupprecht, C.E. J. Vet. Diagn. Invest. (1996) [Pubmed]
  15. Somatostatin, galanin and peptide histidine isoleucine in the newborn and adult human trigeminal ganglion and spinal nucleus: immunohistochemistry, neuronal morphometry and colocalization with substance P. Del Fiacco, M., Quartu, M. J. Chem. Neuroanat. (1994) [Pubmed]
  16. Reduction of ethylnitrosourea-induced neoplastic proliferation in rat trigeminal nerves by nerve growth factor. Vinores, S.A., Koestner, A. Cancer Res. (1982) [Pubmed]
  17. Gene expression of bone matrix proteins and endothelin receptors in endothelin-1-deficient mice revealed by in situ hybridization. Kitano, Y., Kurihara, H., Kurihara, Y., Maemura, K., Ryo, Y., Yazaki, Y., Harii, K. J. Bone Miner. Res. (1998) [Pubmed]
  18. Absence of parasympathetic vasodilatation in cat dental pulp. Sasano, T., Shoji, N., Kuriwada, S., Sanjo, D., Izumi, H., Karita, K. J. Dent. Res. (1995) [Pubmed]
  19. Frequency dependent activation of a slow N-methyl-D-aspartate-dependent excitatory postsynaptic potential in turtle cerebellum by mossy fibre afferents. Larson-Prior, L.J., Morrison, P.D., Bushey, R.M., Slater, N.T. Neuroscience (1995) [Pubmed]
  20. Trigeminal nerve ganglion stimulation-induced neurovascular reflexes in the anaesthetized cat: role of endothelin(B) receptors in carotid vasodilatation. Raval, P., Bingham, S., Aiyar, N., Elliott, J.D., Hunter, A.J., Ohlstein, E.H., Parsons, A.A. Br. J. Pharmacol. (1999) [Pubmed]
  21. Regional variation in expression of acetylcholinesterase mRNA in adult rat brain analyzed by in situ hybridization. Hammond, P., Rao, R., Koenigsberger, C., Brimijoin, S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  22. Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human. Mezey, E., Tóth, Z.E., Cortright, D.N., Arzubi, M.K., Krause, J.E., Elde, R., Guo, A., Blumberg, P.M., Szallasi, A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  23. Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression. Bondy, C.A., Werner, H., Roberts, C.T., LeRoith, D. Mol. Endocrinol. (1990) [Pubmed]
  24. The Gem GTP-binding protein promotes morphological differentiation in neuroblastoma. Leone, A., Mitsiades, N., Ward, Y., Spinelli, B., Poulaki, V., Tsokos, M., Kelly, K. Oncogene (2001) [Pubmed]
  25. Magnetic resonance angiography in facial and other pain: neurovascular mechanisms of trigeminal sensation. May, A., Büchel, C., Turner, R., Goadsby, P.J. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  26. Calcitonin gene-related peptide: functional role in cerebrovascular regulation. McCulloch, J., Uddman, R., Kingman, T.A., Edvinsson, L. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  27. Persistence of attacks of cluster headache after trigeminal nerve root section. Matharu, M.S., Goadsby, P.J. Brain (2002) [Pubmed]
  28. Trigeminal neuropathy secondary to perineural invasion of head and neck carcinomas. Boerman, R.H., Maassen, E.M., Joosten, J., Kaanders, H.A., Marres, H.A., van Overbeeke, J., De Wilde, P. Neurology (1999) [Pubmed]
  29. Idiopathic trigeminal sensory neuropathy with gadolinium enhancement in the cisternal segment. Seidel, E., Hansen, C., Urban, P.P., Vogt, T., Müller-Forell, W., Hopf, H.C. Neurology (2000) [Pubmed]
  30. Sumatriptan in the treatment of migraine. Ferrari, M.D. Neurology (1993) [Pubmed]
  31. Transcriptional mRNA of bone morphogenetic proteins 2, 3, 4, and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors. Tang, C.S., Jin, Y., Cheng, K.I., Yu, K.L., Suwa, F., Nakatsuji, I., Makigusa, K., Fang, Y.R. The Kaohsiung journal of medical sciences. (2001) [Pubmed]
  32. Neuronal and nonneuronal expression of neurotrophins and their receptors in sensory and sympathetic ganglia suggest new intercellular trophic interactions. Wetmore, C., Olson, L. J. Comp. Neurol. (1995) [Pubmed]
  33. GFAP immunoreactivity and transcription in trigeminal and dental tissues of rats and transgenic GFP/GFAP mice. Byers, M.R., Maeda, T., Brown, A.M., Westenbroek, R.E. Microsc. Res. Tech. (2004) [Pubmed]
  34. Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors. Jin, Y., Lu, H.B., Liong, E., Lau, T.Y., Tipoe, G.L. Histol. Histopathol. (2001) [Pubmed]
  35. A quantitative study of the progress of myelination in the rat central nervous system, using the immunohistochemical method for proteolipid protein. Hamano, K., Takeya, T., Iwasaki, N., Nakayama, J., Ohto, T., Okada, Y. Brain Res. Dev. Brain Res. (1998) [Pubmed]
  36. Capsaicin-insensitive sensory-efferent meningeal vasodilatation evoked by electrical stimulation of trigeminal nerve fibres in the rat. Peitl, B., Pethô, G., Pórszász, R., Németh, J., Szolcsányi, J. Br. J. Pharmacol. (1999) [Pubmed]
  37. Trigeminal projections in snakes possessing infrared sensitivity. Schroeder, D.M., Loop, M.S. J. Comp. Neurol. (1976) [Pubmed]
  38. Two cases of medically and surgically intractable SUNCT: a reason for caution and an argument for a central mechanism. Black, D.F., Dodick, D.W. Cephalalgia : an international journal of headache. (2002) [Pubmed]
  39. The ontogeny of substance P fibers in the mouse trigeminal nerve. Mohamed, S.S., Atkinson, M.E. Brain Res. (1982) [Pubmed]
  40. Protective and defensive airway reflexes evoked by nasal exposure to wood smoke in anesthetized rats. Ho, C.L., Kou, Y.R. J. Appl. Physiol. (2000) [Pubmed]
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