Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Bonefos (dichloro-phosphono- methyl)phosphonic acid

Synonyms: Clodronate, Clodronic Acid, Acid, Clodronic, Sodium, Clodronate, Disodium, Clodronate, ...

Dunn, C.J. et al., Caicedo, A. et al., Ahlmark, M. et al., Hurst, M. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Dichloromethanediphosphonic acid

Like other members of its class, the bisphosphonate clodronate (clodronic acid) inhibits bone resorption [1].

High impact information on Dichloromethanediphosphonic acid

Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel clodronic acid dianhydrides as bioreversible prodrugs of clodronate [2].
Depleting circulating macrophages with clodronic acid diminished the density of F4/80 immunoreactive cells as well as the density of pERK immunoreactive Muller cells in the retina under CNV [3].
Although 3-day intravenous therapy with etidronic acid 7.5 mg/kg/day has shown superior efficacy to rehydration and forced diuresis in the management of hypercalcaemia of malignancy, the efficacy of the drug is lower than that of the newer bisphosphonates, pamidronic acid and clodronic acid [4].

References

Clodronate: a review of its use in breast cancer. Hurst, M., Noble, S. Drugs & aging. (1999) [Pubmed]
Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel clodronic acid dianhydrides as bioreversible prodrugs of clodronate. Ahlmark, M., Vepsäläinen, J., Taipale, H., Niemi, R., Järvinen, T. J. Med. Chem. (1999) [Pubmed]
Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization. Caicedo, A., Espinosa-Heidmann, D.G., Piña, Y., Hernandez, E.P., Cousins, S.W. Exp. Eye Res. (2005) [Pubmed]
Etidronic acid. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease. Dunn, C.J., Fitton, A., Sorkin, E.M. Drugs & aging. (1994) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share