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MeSH Review

Fluid Therapy

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Disease relevance of Fluid Therapy


Psychiatry related information on Fluid Therapy

  • 1. The effects of urine flow rate and urinary pH on renal prostaglandin E2 (PGE2) and kallikrein excretion were investigated in conscious dogs during water deprivation followed by rehydration and under conditions which altered urine pH, but caused similar change in salt and water excretion [6].

High impact information on Fluid Therapy

  • The intake of oral rehydration solution was significantly lower in the racecadotril group than in the placebo group (P<0.001) [7].
  • Treatment with bismuth subsalicylate decreases the duration of diarrhea and is a safe and effective adjunct to oral rehydration therapy for infants and young children with acute watery diarrhea [8].
  • In infants the treatment of acute diarrhea with glucose-based solutions results in rehydration but does not reduce the severity of diarrhea [9].
  • Oral rehydration: is it as good as parenteral therapy [10]?
  • None of the 26 patients suspected to have cholera received appropriate fluids; severely dehydrated patients did not receive Ringer's lactate solution and those not severely dehydrated did not receive an oral rehydration solution [11].

Chemical compound and disease context of Fluid Therapy


Biological context of Fluid Therapy

  • As a new biochemical mechanism for peptide bond synthesis that has a potential for applications in biotechnology, it is here proposed that the energy necessary to drive peptide synthesis from free peptides comes from the sizable free energy drop associated with rehydration of the active site of pepsin in 55 M water [16].
  • Energy transfer to PSII and PSI by the respective antennae was fully established within 10 to 20 min of rehydration [17].
  • Episodes of nausea and/or vomiting requiring no specific therapy were observed in groups A, B and D. Nifedipine-treated groups also had a significant fall in blood pressure which was controlled by rehydration [18].
  • CONCLUSION: Catecholamines can alter the intravascular volume expansion of fluid therapy. beta-Receptor (isoproterenol) stimulation augmented blood volume expansion, whereas alpha (phenylephrine) stimulation reduced blood volume expansion [19].
  • We have previously shown that rehydration of the naturally desiccated lichen Ramalina lacera resulted in a rapid increase in photosynthesis and was accompanied by a burst of intracellular production of reactive oxygen species and nitric oxide, as well as a transient decrease in water-soluble antioxidant capacity [20].

Anatomical context of Fluid Therapy


Associations of Fluid Therapy with chemical compounds


Gene context of Fluid Therapy


Analytical, diagnostic and therapeutic context of Fluid Therapy


  1. The acidosis of cholera. Contributions of hyperproteinemia, lactic acidemia, and hyperphosphatemia to an increased serum anion gap. Wang, F., Butler, T., Rabbani, G.H., Jones, P.K. N. Engl. J. Med. (1986) [Pubmed]
  2. Severe hyperglycemia: effects of rehydration on endocrine derangements and blood glucose concentration. Waldhäusl, W., Kleinberger, G., Korn, A., Dudczak, R., Bratusch-Marrain, P., Nowotny, P. Diabetes (1979) [Pubmed]
  3. In vivo targeting of acoustically reflective liposomes for intravascular and transvascular ultrasonic enhancement. Demos, S.M., Alkan-Onyuksel, H., Kane, B.J., Ramani, K., Nagaraj, A., Greene, R., Klegerman, M., McPherson, D.D. J. Am. Coll. Cardiol. (1999) [Pubmed]
  4. Oral rehydration therapy: efficacy of sodium citrate equals to sodium bicarbonate for correction of acidosis in diarrhoea. Islam, M.R., Samadi, A.R., Ahmed, S.M., Bardhan, P.K., Ali, A. Gut (1984) [Pubmed]
  5. Etidronate disodium in the management of malignancy-related hypercalcemia. Hasling, C., Charles, P., Mosekilde, L. Am. J. Med. (1987) [Pubmed]
  6. Effect of urinary pH and urine flow rate on prostaglandin E2 and kallikrein excretion by the conscious dog. Filep, J., Földes-Filep, E. J. Physiol. (Lond.) (1987) [Pubmed]
  7. Racecadotril in the treatment of acute watery diarrhea in children. Salazar-Lindo, E., Santisteban-Ponce, J., Chea-Woo, E., Gutierrez, M. N. Engl. J. Med. (2000) [Pubmed]
  8. A controlled trial of bismuth subsalicylate in infants with acute watery diarrheal disease. Figueroa-Quintanilla, D., Salazar-Lindo, E., Sack, R.B., León-Barúa, R., Sarabia-Arce, S., Campos-Sánchez, M., Eyzaguirre-Maccan, E. N. Engl. J. Med. (1993) [Pubmed]
  9. Rice-based oral electrolyte solutions for the management of infantile diarrhea. Pizarro, D., Posada, G., Sandi, L., Moran, J.R. N. Engl. J. Med. (1991) [Pubmed]
  10. Oral rehydration: is it as good as parenteral therapy? Carpenter, C.C. N. Engl. J. Med. (1982) [Pubmed]
  11. Diagnosis and treatment of cholera in the United States. Are we prepared? Besser, R.E., Feikin, D.R., Eberhart-Phillips, J.E., Mascola, L., Griffin, P.M. JAMA (1994) [Pubmed]
  12. CYP707A3, a major ABA 8'-hydroxylase involved in dehydration and rehydration response in Arabidopsis thaliana. Umezawa, T., Okamoto, M., Kushiro, T., Nambara, E., Oono, Y., Seki, M., Kobayashi, M., Koshiba, T., Kamiya, Y., Shinozaki, K. Plant J. (2006) [Pubmed]
  13. Chronic epidural bupivacaine-opioid infusion in intractable cancer pain. Du Pen, S.L., Kharasch, E.D., Williams, A., Peterson, D.G., Sloan, D.C., Hasche-Klunder, H., Krembs, A.W. Pain (1992) [Pubmed]
  14. 3-Hydroxyisobutyric aciduria: an inborn error of valine metabolism. Ko, F.J., Nyhan, W.L., Wolff, J., Barshop, B., Sweetman, L. Pediatr. Res. (1991) [Pubmed]
  15. Mineral excretion during acute, dehydrating diarrhea treated with oral rehydration therapy. Ruz, M., Solomons, N.W. Pediatr. Res. (1990) [Pubmed]
  16. Transpeptidation by porcine pepsin catalyzed by a noncovalent intermediate unique to its iso-mechanism. Cho, Y.K., Northrop, D.B. J. Biol. Chem. (1998) [Pubmed]
  17. Activation of photosynthesis and resistance to photoinhibition in cyanobacteria within biological desert crust. Harel, Y., Ohad, I., Kaplan, A. Plant Physiol. (2004) [Pubmed]
  18. Enhancement of the epidural morphine-induced analgesia by systemic nifedipine. Pereira, I.T., Prado, W.A., Dos Reis, M.P. Pain (1993) [Pubmed]
  19. Effects of different catecholamines on the dynamics of volume expansion of crystalloid infusion. Vane, L.A., Prough, D.S., Kinsky, M.A., Williams, C.A., Grady, J.J., Kramer, G.C. Anesthesiology (2004) [Pubmed]
  20. Characterization of enzymatic antioxidants in the lichen Ramalina lacera and their response to rehydration. Weissman, L., Garty, J., Hochman, A. Appl. Environ. Microbiol. (2005) [Pubmed]
  21. Oral rehydration therapy: new explanations for an old remedy. Rao, M.C. Annu. Rev. Physiol. (2004) [Pubmed]
  22. Hypothalamic paraventricular nucleus differentially supports lumbar and renal sympathetic outflow in water-deprived rats. Stocker, S.D., Hunwick, K.J., Toney, G.M. J. Physiol. (Lond.) (2005) [Pubmed]
  23. Dehydration and rehydration selectively and reversibly alter glial fibrillary acidic protein immunoreactivity in the rat supraoptic nucleus and subjacent glial limitans. Hawrylak, N., Fleming, J.C., Salm, A.K. Glia (1998) [Pubmed]
  24. Treatment of acute infectious diarrhoea in infants and children with a mixture of three Lactobacillus rhamnosus strains--a randomized, double-blind, placebo-controlled trial. Szymański, H., Pejcz, J., Jawień, M., Chmielarczyk, A., Strus, M., Heczko, P.B. Aliment. Pharmacol. Ther. (2006) [Pubmed]
  25. Sterile connector. Tenczar, F.J. Transfusion (1976) [Pubmed]
  26. Evaluation of a sucrose/electrolyte solution for oral rehydration in acute infantile diarrhoea. Chatterjee, A., Mahalanabis, D., Jalan, K.N., Maitra, T.K., Agarwal, S.K., Bagchi, D.K., Indra, S. Lancet (1977) [Pubmed]
  27. L-glutamine stimulates jejunal sodium and chloride absorption in pig rotavirus enteritis. Rhoads, J.M., Keku, E.O., Quinn, J., Woosely, J., Lecce, J.G. Gastroenterology (1991) [Pubmed]
  28. Oral rehydration without chloride. Hill, G.W. Lancet (1988) [Pubmed]
  29. The use of chlorpromazine in the treatment of cholera and other severe acute watery diarrheal diseases. Islam, M.R., Sack, D.A., Holmgren, J., Bardhan, P.K., Rabbani, G.H. Gastroenterology (1982) [Pubmed]
  30. Renal salt wasting in patients treated with cisplatin. Hutchison, F.N., Perez, E.A., Gandara, D.R., Lawrence, H.J., Kaysen, G.A. Ann. Intern. Med. (1988) [Pubmed]
  31. Growth hormone and prolactin response to rehydration during exercise: effect of water and carbohydrate solutions. Saini, J., Bothorel, B., Brandenberger, G., Candas, V., Follenius, M. European journal of applied physiology and occupational physiology. (1990) [Pubmed]
  32. Assignment of the human Na+/glucose cotransporter gene SGLT1 to chromosome 22q13.1. Turk, E., Klisak, I., Bacallao, R., Sparkes, R.S., Wright, E.M. Genomics (1993) [Pubmed]
  33. Effects of water deprivation and rehydration on c-Fos and FosB staining in the rat supraoptic nucleus and lamina terminalis region. Ji, L.L., Fleming, T., Penny, M.L., Toney, G.M., Cunningham, J.T. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005) [Pubmed]
  34. Molecular dynamics simulations of the rehydration of folded and unfolded cytochrome C ions in the vapor phase. Mao, Y., Ratner, M.A., Jarrold, M.F. J. Am. Chem. Soc. (2001) [Pubmed]
  35. Effect of rehydration on atrial natriuretic peptide release during exercise in the heat. Follenius, M., Candas, V., Bothorel, B., Brandenberger, G. J. Appl. Physiol. (1989) [Pubmed]
  36. Identification in traditional herbal medications and confirmation by synthesis of factors that inhibit cholera toxin-induced fluid accumulation. Oi, H., Matsuura, D., Miyake, M., Ueno, M., Takai, I., Yamamoto, T., Kubo, M., Moss, J., Noda, M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  37. Effect of bicarbonate on efficacy of oral rehydration therapy: studies in an experimental model of secretory diarrhoea. Elliott, E.J., Watson, A.J., Walker-Smith, J.A., Farthing, M.J. Gut (1988) [Pubmed]
  38. Evidence of a dominant role for low osmolality in the efficacy of cereal based oral rehydration solutions: studies in a model of secretory diarrhoea. Thillainayagam, A.V., Carnaby, S., Dias, J.A., Clark, M.L., Farthing, M.J. Gut (1993) [Pubmed]
  39. Revival of a resurrection plant correlates with its antioxidant status. Kranner, I., Beckett, R.P., Wornik, S., Zorn, M., Pfeifhofer, H.W. Plant J. (2002) [Pubmed]
  40. Isolation, chromosomal localization, and differential expression of mitochondrial manganese superoxide dismutase and chloroplastic copper/zinc superoxide dismutase genes in wheat. Wu, G., Wilen, R.W., Robertson, A.J., Gusta, L.V. Plant Physiol. (1999) [Pubmed]
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