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Chemical Compound Review: 

Coropres     1-(9H-carbazol-4-yloxy)-3-[2- (2...

Synonyms: Eucardic, Coropress, Dilatrend, Artist, Dibloc, ...
 
 
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Disease relevance of carvedilol

  • The effect of carvedilol (CAS 72956-09-3, Artist), and alpha-/beta-blocking agent, on hepatic and systemic hemodynamics in 10 patients with portal hypertension was evaluated [1].
  • We hypothesize that such signaling may contribute to the special efficacy of carvedilol in the treatment of heart failure and may serve as a prototype for a new generation of therapeutic beta2AR ligands [2].
 

High impact information on carvedilol

  • ECE-1 mRNA was unaltered in the CARV and LOS group and was decreased by 20% in the QIN group [3].
  • CARV also reduced blood pressure but did not normalize it [3].
  • LV weight was increased in the Ren-2 rats compared to SD rats, and was significantly reduced to normal in the LOS and QIN but not in the CARV group [3].
  • Carvedilol (CAS 72956-09-3, Dilatrend) is a beta-blocker with additional vasodilating, antiproliferative and antioxidative properties [4].

References

  1. Effects of the alpha-/beta-blocking agent carvedilol on hepatic and systemic hemodynamics in patients with cirrhosis and portal hypertension. Sekiyama, T., Komeichi, H., Nagano, T., Ohsuga, M., Terada, H., Katsuta, Y., Satomura, K., Aramaki, T. Arzneimittel-Forschung. (1997) [Pubmed]
  2. A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Wisler, J.W., DeWire, S.M., Whalen, E.J., Violin, J.D., Drake, M.T., Ahn, S., Shenoy, S.K., Lefkowitz, R.J. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  3. Interaction of the renin-angiotensin system and the endothelin system in cardiac hypertrophy. Stula, M., Pinto, Y.M., Gschwend, S., Teisman, A.C., van Gilst, W.H., Böhm, M., Dietz, R., Paul, M. J. Cardiovasc. Pharmacol. (1998) [Pubmed]
  4. In vitro absorption studies with carvedilol using a new model with porcine intestine called BM-RIMO (Boehringer-Mannheim ring model). Nolte, K., Backfisch, G., Neidlein, R. Arzneimittel-Forschung. (1999) [Pubmed]
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