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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Heart Failure

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Chemical compound and disease context of Heart Failure


Gene context of Heart Failure

  • Adrenal gland-specific GRK2 inhibition reversed alpha2AR dysregulation in heart failure, resulting in lowered plasma catecholamine levels, improved cardiac betaAR signaling and function, and increased sympatholytic efficacy of a alpha2AR agonist [3].
  • ADRB1 and ADRA2C polymorphisms synergistically influence the ejection fraction response to beta-blocker therapy of heart failure patients [4].
  • Two SNPs (IVS-4 G/A and Lys198Asn) in the endothelin-1 gene, however, predicted time to the combined endpoint of heart failure hospitalization or all-cause death in bucindolol-treated patients [5].


  1. Levosimendan: beyond its simple inotropic effect in heart failure. Antoniades, C., Tousoulis, D., Koumallos, N., Marinou, K., Stefanadis, C. Pharmacol. Ther. (2007) [Pubmed]
  2. Proteomic analysis of left ventricular remodeling in an experimental model of heart failure. Cieniewski-Bernard, C., Mulder, P., Henry, J.P., Drobecq, H., Dubois, E., Pottiez, G., Thuillez, C., Amouyel, P., Richard, V., Pinet, F. J. Proteome Res. (2008) [Pubmed]
  3. Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure. Lymperopoulos, A., Rengo, G., Funakoshi, H., Eckhart, A.D., Koch, W.J. Nat. Med. (2007) [Pubmed]
  4. Synergistic polymorphisms of beta1 and alpha2C-adrenergic receptors and the influence on left ventricular ejection fraction response to beta-blocker therapy in heart failure. Lobmeyer, M.T., Gong, Y., Terra, S.G., Beitelshees, A.L., Langaee, T.Y., Pauly, D.F., Schofield, R.S., Hamilton, K.K., Herbert Patterson, J., Adams, K.F., Hill, J.A., Aranda, J.M., Johnson, J.A. Pharmacogenet. Genomics (2007) [Pubmed]
  5. Pharmacogenetic effect of an endothelin-1 haplotype on response to bucindolol therapy in chronic heart failure. Taylor, M.R., Slavov, D., Humphrey, K., Zhao, L., Cockroft, J., Zhu, X., Lavori, P., Bristow, M.R., Mestroni, L., Lazzeroni, L.C. Pharmacogenet. Genomics (2009) [Pubmed]
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