Gene Review:
Ren2 - renin 2 tandem duplication of Ren1
Mus musculus
Synonyms:
Angiotensinogenase, Ren, Ren-1, Ren-2, Ren-B, ...
- Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats. Kantachuvesiri, S., Haley, C.S., Fleming, S., Kurian, K., Whitworth, C.E., Wenham, P., Kotelevtsev, Y., Mullins, J.J. Kidney Int. (1999)
- Effect of melatonin on exploration and anxiety in normotensive and hypertensive rats with high activity of renin-angiotensin system. Krsková, L., Vrabcová, M., Zeman, M. Neuro. Endocrinol. Lett. (2007)
- Ren1d and Ren2 cooperate to preserve homeostasis: evidence from mice expressing GFP in place of Ren1d. Pentz, E.S., Lopez, M.L., Kim, H.S., Carretero, O., Smithies, O., Gomez, R.A. Physiol. Genomics (2001)
- Renin-promoter SV40 large T-antigen transgenes induce tumors irrespective of normal cellular expression of renin genes. Sola, C., Tronik, D., Dreyfus, M., Babinet, C., Rougeon, F. Oncogene Res. (1989)
- Proximal tubule microvilli remodeling and albuminuria in the Ren2 transgenic rat. Hayden, M.R., Chowdhury, N.A., Cooper, S.A., Whaley-Connell, A., Habibi, J., Witte, L., Wiedmeyer, C., Manrique, C.M., Lastra, G., Ferrario, C., Stump, C., Sowers, J.R. Am. J. Physiol. Renal Physiol. (2007)
- Effects of angiotensin II subtype 1 receptor blockade on cardiac fibrosis and sarcoplasmic reticulum Ca2+ handling in hypertensive transgenic rats overexpressing the Ren2 gene. Rothermund, L., Pinto, Y.M., Vetter, R., Herfort, N., Kossmehl, P., Neumayer, H.H., Paul, M., Kreutz, R. J. Hypertens. (2001)
- A DNA polymorphism, consistent with gene duplication, correlates with high renin levels in the mouse submaxillary gland. Piccini, N., Knopf, J.L., Gross, K.W. Cell (1982)
- Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Mullins, J.J., Peters, J., Ganten, D. Nature (1990)
- Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes. Merrill, D.C., Thompson, M.W., Carney, C.L., Granwehr, B.P., Schlager, G., Robillard, J.E., Sigmund, C.D. J. Clin. Invest. (1996)
- Expression of the DBA/2J Ren-2 gene in the adrenal gland of transgenic mice. Mullins, J.J., Sigmund, C.D., Kane-Haas, C., Gross, K.W., McGowan, R.A. EMBO J. (1989)
- Nifedipine, losartan and captopril effects on hyperplasia of vascular smooth muscle from Ren-2 transgenic rats. Peiró, C., Angulo, J., Regadera, J., Llergo, J.L., Sánchez-Ferrer, A., Rodríguez-Mañas, L., Sánchez-Ferrer, C.F. Eur. J. Pharmacol. (1997)
- Angiotensin II mediates cell hypertrophy in vascular smooth muscle cultures from hypertensive Ren-2 transgenic rats by an amiloride- and furosemide-sensitive mechanism. Peiró, C., Angulo, J., Llergo, J.L., Rodríguez-Mañas, L., Marín, J., Sánchez-Ferrer, C.F. Biochem. Biophys. Res. Commun. (1997)
- Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy. Mifsud, S., Kelly, D.J., Qi, W., Zhang, Y., Pollock, C.A., Wilkinson-Berka, J.L., Gilbert, R.E. Nephron. Physiology [electronic resource]. (2003)
- Dual renin gene targeting by Cre-mediated interchromosomal recombination. Matsusaka, T., Kon, V., Takaya, J., Katori, H., Chen, X., Miyazaki, J., Homma, T., Fogo, A., Ichikawa, I. Genomics (2000)
- Thyroxine and testosterone transcriptionally regulate renin gene expression in the submaxillary gland of normal and transgenic mice carrying extra copies of the Ren2 gene. Tronik, D., Rougeon, F. FEBS Lett. (1988)
- Kidney and submaxillary gland renins are encoded by two non-allelic genes in Swiss mice. Panthier, J.J., Rougeon, F. EMBO J. (1983)
- Differential extra-renal expression of the mouse renin genes. Miller, C.C., Carter, A.T., Brooks, J.I., Lovell-Badge, R.H., Brammar, W.J. Nucleic Acids Res. (1989)
- The activity of the mouse renin promoter in cells that do not normally produce renin is dependent upon the presence of a functional enhancer. Ekker, M., Sola, C., Rougeon, F. FEBS Lett. (1989)
- The angiotensinogen gene of Swiss mice is closely linked to a retrovirus-like element. Clouston, W.M. DNA Cell Biol. (1990)
- Ontogenetic regulation of mouse Ren-2d renin gene in transgenic hypertensive rats, TGR(mREN2)27. Zhao, Y., Bader, M., Kreutz, R., Fernandez-Alfonso, M., Zimmermann, F., Ganten, U., Metzger, R., Ganten, D., Mullins, J.J., Peters, J. Am. J. Physiol. (1993)
- Tissue and gene specificity of mouse renin expression. Field, L.J., McGowan, R.A., Dickinson, D.P., Gross, K.W. Hypertension (1984)
- Salt-sensitive hypertension develops after transient induction of ANG II-dependent hypertension in Cyp1a1-Ren2 transgenic rats. Howard, L.L., Patterson, M.E., Mullins, J.J., Mitchell, K.D. Am. J. Physiol. Renal Physiol. (2005)
- The crystal structure of the mouse glandular kallikrein-13 (prorenin converting enzyme). Timm, D.E. Protein Sci. (1997)
- Immunocytochemical localization of renin in kidneys and submandibular glands of SWR/J and C57BL/6J mice. Tanaka, T., Gresik, E.W., Michelakis, A.M., Barka, T. J. Histochem. Cytochem. (1980)
- Mechanisms of hypertension in transgenic rats expressing the mouse Ren-2 gene. Moriguchi, A., Brosnihan, K.B., Kumagai, H., Ganten, D., Ferrario, C.M. Am. J. Physiol. (1994)
- Ablation of renin-expressing juxtaglomerular cells results in a distinct kidney phenotype. Pentz, E.S., Moyano, M.A., Thornhill, B.A., Sequeira Lopez, M.L., Gomez, R.A. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004)
- Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse. Wilson, C.M., Erdös, E.G., Wilson, J.D., Taylor, B.A. Proc. Natl. Acad. Sci. U.S.A. (1978)
- Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22). Kikkawa, Y., Yamanaka, N., Tada, J., Kanamori, N., Tsumura, K., Hosoi, K. Biochim. Biophys. Acta (1998)
- A processing enzyme for prorenin in mouse submandibular gland. Purification and characterization. Kim, W.S., Hatsuzawa, K., Ishizuka, Y., Hashiba, K., Murakami, K., Nakayama, K. J. Biol. Chem. (1990)
- Targeted inactivation of the Ren-2 gene in mice. Sharp, M.G., Fettes, D., Brooker, G., Clark, A.F., Peters, J., Fleming, S., Mullins, J.J. Hypertension (1996)
- Ren-2 as well as Ren-1 renin exists in the kidney and plasma of a two-renin gene mouse. Suzuki, F., Yamashita, S., Ito, M., Nagata, Y., Nakamura, Y. Agric. Biol. Chem. (1990)