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Chemical Compound Review:

Chlorisept 5-chloroquinolin-8-ol

Synonyms: cloxyquin, Cloxiquina, Cloxiquine, Cloxiquinum, Dermofongin, ...

Cosgrove, R.F. et al., Malaveille, C. et al., Wantke, F. et al.

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Disease relevance of Chlorisept

The in vitro activities of 5-chloro-8-hydroxyquinoline (CHQ) against single strains of 12 different species of mycoplasma and the impacts of repeated exposure of these strains to CHQ on their susceptibility to this agent have been studied [1].
Contact dermatitis from cloxyquin [2].

High impact information on Chlorisept

At a concentration range of 0.1-4 mM, ochratoxin A, chloroxine, 5-chloro-8-quinolinol, 4-chloro-meta-cresol and chloroxylenol were found to induce SOS-DNA repair in the absence of an exogenous metabolic activation system [3].

References

In vitro activity of chlorhydroxyquinoline against mycoplasma species. Cosgrove, R.F., Baines, S. Antimicrob. Agents Chemother. (1978) [Pubmed]
Contact dermatitis from cloxyquin. Wantke, F., Götz, M., Jarisch, R. Contact Derm. (1995) [Pubmed]
Genotoxicity of ochratoxin A and structurally related compounds in Escherichia coli strains: studies on their mode of action. Malaveille, C., Brun, G., Bartsch, H. IARC Sci. Publ. (1991) [Pubmed]

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