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Chemical Compound Review

CCRIS 2382     2-[[(3R)-5-chloro-8-hydroxy- 3-methyl-1-oxo...

Synonyms: NCI-C56586, HSDB 4305, AC1L1SUM, NSC 201422, BRN 1301486, ...
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Disease relevance of OCHRATOXIN A


Psychiatry related information on OCHRATOXIN A


High impact information on OCHRATOXIN A

  • The potential carcinogenic effects of the mycotoxin ochratoxin A [(OA); CAS: 303-47-9] were assessed in a 24-month feeding study in male and female (C57BL/6J X C3H)F1 (B6C3F1) mice [9].
  • Analysis of ochratoxin A (OTA) in wine by LC/MS and multiple mass spectrometry (MS/MS) permits to confirm the toxin presence without the use of expensive immunoaffinity columns, or time and solvent consuming sample derivatization procedures [10].
  • Because uptake by isolated hepatocytes was not dependent on sodium ions and was blocked by ochratoxin A, we assume basolateral transport by an oatp-type bile acid carrier [11].
  • Development of human cytochrome P450-expressing cell lines: application in mutagenicity testing of ochratoxin A [12].
  • Natural occurrence of ochratoxin A in food commodities has been linked to an increased incidence of urinary tract tumors in certain geographic regions [12].

Chemical compound and disease context of OCHRATOXIN A


Biological context of OCHRATOXIN A


Anatomical context of OCHRATOXIN A


Associations of OCHRATOXIN A with other chemical compounds


Gene context of OCHRATOXIN A


Analytical, diagnostic and therapeutic context of OCHRATOXIN A


  1. Molecular aspects of the transport and toxicity of ochratoxin a. Dai, J., Park, G., Perry, J.L., Il'ichev, Y.V., Bow, D.A., Pritchard, J.B., Faucet, V., Pfohl-Leszkowicz, A., Manderville, R.A., Simon, J.D. Acc. Chem. Res. (2004) [Pubmed]
  2. Selective immunosuppression in mice of natural killer cell activity by ochratoxin A. Luster, M.I., Germolec, D.R., Burleson, G.R., Jameson, C.W., Ackermann, M.F., Lamm, K.R., Hayes, H.T. Cancer Res. (1987) [Pubmed]
  3. Chemically induced renal tubule tumors in the laboratory rat and mouse: review of the NCI/NTP database and categorization of renal carcinogens based on mechanistic information. Lock, E.A., Hard, G.C. Crit. Rev. Toxicol. (2004) [Pubmed]
  4. Sex- and strain-specific induction of renal tumors by ochratoxin A in rats correlates with DNA adduction. Castegnaro, M., Mohr, U., Pfohl-Leszkowicz, A., Estève, J., Steinmann, J., Tillmann, T., Michelon, J., Bartsch, H. Int. J. Cancer (1998) [Pubmed]
  5. Metabolism of ochratoxin A by rats. Støren, O., Holm, H., Størmer, F.C. Appl. Environ. Microbiol. (1982) [Pubmed]
  6. Presence of ochratoxin A in human milk in relation to dietary intake. Skaug, M.A., Helland, I., Solvoll, K., Saugstad, O.D. Food additives and contaminants. (2001) [Pubmed]
  7. Critical period and minimum single oral dose of ochratoxin A for inducing developmental toxicity in pregnant Wistar rats. Patil, R.D., Dwivedi, P., Sharma, A.K. Reprod. Toxicol. (2006) [Pubmed]
  8. Multifactorial determination of hypertensive nephroangiosclerosis. Tylicki, L., Rutkowski, B., Hörl, W.H. Kidney Blood Press. Res. (2002) [Pubmed]
  9. Ochratoxin A carcinogenesis in the (C57BL/6J X C3H)F1 mouse. Bendele, A.M., Carlton, W.W., Krogh, P., Lillehoj, E.B. J. Natl. Cancer Inst. (1985) [Pubmed]
  10. Mass spectrometry in grape and wine chemistry. Part II: The consumer protection. Flamini, R., Panighel, A. Mass spectrometry reviews. (2006) [Pubmed]
  11. Hepatobiliary transport of bile acid amino acid, bile acid peptide, and bile acid oligonucleotide conjugates in rats. Petzinger, E., Wickboldt, A., Pagels, P., Starke, D., Kramer, W. Hepatology (1999) [Pubmed]
  12. Development of human cytochrome P450-expressing cell lines: application in mutagenicity testing of ochratoxin A. de Groene, E.M., Hassing, I.G., Blom, M.J., Seinen, W., Fink-Gremmels, J., Horbach, G.J. Cancer Res. (1996) [Pubmed]
  13. Inhibition of phenylalanine tRNA synthetase from Bacillus subtilis by ochratoxin A. Konrad, I., Röschenthaler, R. FEBS Lett. (1977) [Pubmed]
  14. Extracellular acidosis ameliorates metabolic-inhibitor-induced and potentiates oxidant-induced cell death in renal proximal tubules. Rodeheaver, D.P., Schnellmann, R.G. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  15. Lack of mutagenicity of ochratoxin A and B, citrinin, patulin and cnestine in Salmonella typhimurium TA102. Würgler, F.E., Friederich, U., Schlatter, J. Mutat. Res. (1991) [Pubmed]
  16. Mitochondrial dysfunction is an early event in ochratoxin A but not oosporein toxicity to rat renal proximal tubules. Aleo, M.D., Wyatt, R.D., Schnellmann, R.G. Toxicol. Appl. Pharmacol. (1991) [Pubmed]
  17. Co-occurrence of ochratoxin A and citrinin in cereals from Bulgarian villages with a history of Balkan endemic nephropathy. Vrabcheva, T., Usleber, E., Dietrich, R., Märtlbauer, E. J. Agric. Food Chem. (2000) [Pubmed]
  18. Free radical generation as induced by ochratoxin A and its analogs in bacteria (Bacillus brevis). Hoehler, D., Marquardt, R.R., McIntosh, A.R., Xiao, H. J. Biol. Chem. (1996) [Pubmed]
  19. Ochratoxin A secretion in primary cultures of rabbit renal proximal tubule cells. Groves, C.E., Nowak, G., Morales, M. J. Am. Soc. Nephrol. (1999) [Pubmed]
  20. Melatonin counteracts oxidative stress in rats fed an ochratoxin A contaminated diet. Abdel-Wahhab, M.A., Abdel-Galil, M.M., El-Lithey, M. J. Pineal Res. (2005) [Pubmed]
  21. Inhibition of mitochondria prevents cell death in kidney epithelial cells by intra- and extracellular acidification. Schwerdt, G., Freudinger, R., Schuster, C., Silbernagl, S., Gekle, M. Kidney Int. (2003) [Pubmed]
  22. Inhibition of renal gluconeogenesis in rats by ochratoxin. Meisner, H., Selanik, P. Biochem. J. (1979) [Pubmed]
  23. Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. Youngblood, G.L., Sweet, D.H. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  24. Relative contribution of OAT and OCT transporters to organic electrolyte transport in rabbit proximal tubule. Zhang, X., Groves, C.E., Bahn, A., Barendt, W.M., Prado, M.D., Rödiger, M., Chatsudthipong, V., Burckhardt, G., Wright, S.H. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  25. Formation of (4R)- and (4S)-4-hydroxyochratoxin A from ochratoxin A by liver microsomes from various species. Størmer, F.C., Hansen, C.E., Pedersen, J.I., Hvistendahl, G., Aasen, A.J. Appl. Environ. Microbiol. (1981) [Pubmed]
  26. Archaebacterial phenylalanyl-tRNA synthetase. Accuracy of the phenylalanyl-tRNA synthetase from the archaebacterium Methanosarcina barkeri, Zn(II)-dependent synthesis of diadenosine 5',5'''-P1,P4-tetraphosphate, and immunological relationship of OFFnylalanyl-tRNA synthetases from different urkingdoms. Rauhut, R., Gabius, H.J., Engelhardt, R., Cramer, F. J. Biol. Chem. (1985) [Pubmed]
  27. Transport of organic anions across the basolateral membrane of proximal tubule cells. Burckhardt, B.C., Burckhardt, G. Rev. Physiol. Biochem. Pharmacol. (2003) [Pubmed]
  28. Synergistic interaction in simultaneous exposure to Streptomyces californicus and Stachybotrys chartarum. Huttunen, K., Pelkonen, J., Nielsen, K.F., Nuutinen, U., Jussila, J., Hirvonen, M.R. Environ. Health Perspect. (2004) [Pubmed]
  29. Metabolism of aflatoxin, ochratoxin, zearalenone, and three trichothecenes by intact rumen fluid, rumen protozoa, and rumen bacteria. Kiessling, K.H., Pettersson, H., Sandholm, K., Olsen, M. Appl. Environ. Microbiol. (1984) [Pubmed]
  30. Immunosuppression by ochratoxin A and its prevention by phenylalanine. Haubeck, H.D., Lorkowski, G., Kölsch, E., Röschenthaler, R. Appl. Environ. Microbiol. (1981) [Pubmed]
  31. ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Leier, I., Hummel-Eisenbeiss, J., Cui, Y., Keppler, D. Kidney Int. (2000) [Pubmed]
  32. Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules. Anzai, N., Jutabha, P., Enomoto, A., Yokoyama, H., Nonoguchi, H., Hirata, T., Shiraya, K., He, X., Cha, S.H., Takeda, M., Miyazaki, H., Sakata, T., Tomita, K., Igarashi, T., Kanai, Y., Endou, H. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  33. Genetic susceptibility in the neural tube defects induced by ochratoxin A in the genetic arhinencephaly mouse, Pdn/Pdn. Ohta, K., Maekawa, M., Katagiri, R., Ueta, E., Naruse, I. Congenital anomalies. (2006) [Pubmed]
  34. Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. Cha, S.H., Sekine, T., Kusuhara, H., Yu, E., Kim, J.Y., Kim, D.K., Sugiyama, Y., Kanai, Y., Endou, H. J. Biol. Chem. (2000) [Pubmed]
  35. Ochratoxin A-induced renal cortex fibrosis and epithelial-to-mesenchymal transition: molecular mechanisms of ochratoxin A-injury and potential effects of red wine. Gagliano, N., Torri, C., Donetti, E., Grizzi, F., Costa, F., Bertelli, A.A., Migliori, M., Filippi, C., Bedoni, M., Panichi, V., Giovannini, L., Gioia, M. Mol. Med. (2005) [Pubmed]
  36. Strain-specific mammary proliferative lesion development following lifetime oral administration of ochratoxin A in DA and Lewis rats. Son, W.C., Kamino, K., Lee, Y.S., Kang, K.S. Int. J. Cancer (2003) [Pubmed]
  37. Array biosensor for detection of ochratoxin A in cereals and beverages. Ngundi, M.M., Shriver-Lake, L.C., Moore, M.H., Lassman, M.E., Ligler, F.S., Taitt, C.R. Anal. Chem. (2005) [Pubmed]
  38. Ochratoxin A: isolation and subsequent purification by high-pressure liquid chromatography. Peterson, R.E., Ciegler, A. Appl. Environ. Microbiol. (1978) [Pubmed]
  39. Enzyme-linked immunosorbent assay for detection of ochratoxin A. Pestka, J.J., Steinert, B.W., Chu, F.S. Appl. Environ. Microbiol. (1981) [Pubmed]
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