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Chemical Compound Review

CLONIXIN     2-[(3-chloro-2-methyl- phenyl)amino]pyridin...

Synonyms: Chlonixin, Clonixine, Clonixino, Clonixinum, Deltar, ...
 
 
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Disease relevance of CLONIXIN

  • When conformational differences among loops of individual inhibitors were compared using root mean square deviation (rmsd) in atomic coordinates for all main chain atoms (deltar method) and rmsd operating in main chain torsion angles (deltat method), differences of up to 2.1 A and 72.3 degrees, respectively, were observed [1].
 

High impact information on CLONIXIN

  • A2 subunit increased the fluorescence anisotropy of fluorescein-Phe-Phe-Arg-factor IXa (Deltar = 0.015) and markedly increased anisotropy in the presence of factor X (Deltar = 0.057), suggesting that it contributes to the orientation of the factor IXa active site and its relation to substrate [2].
  • A related parameter indicating the degree of order of cross-bridges in muscle fibers, Deltar, was small in rigor fibers (-0.009) and increased in relaxed fibers (0.030) [3].
  • The analgesic effect of clonixine is not mediated by 5-HT3 subtype receptors [4].
 

Analytical, diagnostic and therapeutic context of CLONIXIN

  • For given film and substrate refractive indices, the angle of incidence and film thickness are selected such that the ellipsometric differential phase shifts in reflection and transmission deltar, and deltat, differ by +/- pi/2, and the normalized determinant of the instrument matrix is maximized [5].

References

  1. Variability of the canonical loop conformations in serine proteinases inhibitors and other proteins. Apostoluk, W., Otlewski, J. Proteins (1998) [Pubmed]
  2. The A2 subunit of factor VIIIa modulates the active site of factor IXa. Fay, P.J., Koshibu, K. J. Biol. Chem. (1998) [Pubmed]
  3. The power stroke causes changes in the orientation and mobility of the termini of essential light chain 1 of myosin. Borejdo, J., Ushakov, D.S., Moreland, R., Akopova, I., Reshetnyak, Y., Saraswat, L.D., Kamm, K., Lowey, S. Biochemistry (2001) [Pubmed]
  4. The analgesic effect of clonixine is not mediated by 5-HT3 subtype receptors. Paeile, C., Bustamante, S.E., Sierralta, F., Bustamante, D., Miranda, H.F. Gen. Pharmacol. (1995) [Pubmed]
  5. Single-layer-coated beam splitters for the division-of-amplitude photopolarimeter. Azzam, R.M., Sudradjat, F.F. Applied optics. (2005) [Pubmed]
 
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