Gene Review:
Htr3a - 5-hydroxytryptamine (serotonin) receptor 3A
Mus musculus
Synonyms:
5-HT-3, 5-HT3 receptor, 5-HT3-A, 5-HT3A, 5-HT3R, ...
- Ca2+ permeability of cloned and native 5-hydroxytryptamine type 3 receptors. Hargreaves, A.C., Lummis, S.C., Taylor, C.W. Mol. Pharmacol. (1994)
- Expression of recombinant homo-oligomeric 5-hydroxytryptamine3 receptors provides new insights into their maturation and structure. Green, T., Stauffer, K.A., Lummis, S.C. J. Biol. Chem. (1995)
- Ca2+ influx through voltage-gated Ca2+ channels regulates 5-HT3 receptor channel desensitization in rat glioma x mouse neuroblastoma hybrid NG108-15 cells. Jones, S., Yakel, J.L. J. Physiol. (Lond.) (1998)
- Orally active benzoxazole derivative as 5-HT3 receptor partial agonist for treatment of diarrhea-predominant irritable bowel syndrome. Yoshida, S., Shiokawa, S., Kawano, K., Ito, T., Murakami, H., Suzuki, H., Sato, Y. J. Med. Chem. (2005)
- Characterization of a mouse serotonin 5-HT3 receptor purified from mammalian cells. Hovius, R., Tairi, A.P., Blasey, H., Bernard, A., Lundström, K., Vogel, H. J. Neurochem. (1998)
- Deletion of the 5-HT3 receptor differentially affects behavior of males and females in the Porsolt forced swim and defensive withdrawal tests. Bhatnagar, S., Nowak, N., Babich, L., Bok, L. Behav. Brain Res. (2004)
- 5-HT(3A) receptor subunit is required for 5-HT3 antagonist-induced reductions in alcohol drinking. Hodge, C.W., Kelley, S.P., Bratt, A.M., Iller, K., Schroeder, J.P., Besheer, J. Neuropsychopharmacology (2004)
- Effects of acute administration of the 5-HT3 receptor antagonist, BRL 46470A, on the behaviour of mice in a two compartment light-dark box and during social interactions in their home cage and an unfamiliar neutral cage. Gao, B., Cutler, M.G. Neuropharmacology (1992)
- Role of 5-HT4 receptors in the mouse passive avoidance test. Galeotti, N., Ghelardini, C., Bartolini, A. J. Pharmacol. Exp. Ther. (1998)
- 5-HT3 receptor over-expression decreases ethanol self administration in transgenic mice. Engel, S.R., Lyons, C.R., Allan, A.M. Psychopharmacology (Berl.) (1998)
- Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Labarca, C., Nowak, M.W., Zhang, H., Tang, L., Deshpande, P., Lester, H.A. Nature (1995)
- Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Maricq, A.V., Peterson, A.S., Brake, A.J., Myers, R.M., Julius, D. Science (1991)
- 5-HT3 receptors mediate rapid responses in cultured hippocampus and a clonal cell line. Yakel, J.L., Jackson, M.B. Neuron (1988)
- Functional characterization of two 5-HT3 receptor splice variants isolated from a mouse hippocampal cell line. Glitsch, M., Wischmeyer, E., Karschin, A. Pflugers Arch. (1996)
- Ultrastructure of the 5-hydroxytryptamine3 receptor. Boess, F.G., Beroukhim, R., Martin, I.L. J. Neurochem. (1995)
- Effects of 5-HT3 receptor antagonists on neuroleptic-induced catalepsy in mice. Silva, S.R., Futuro-Neto, H.A., Pires, J.G. Neuropharmacology (1995)
- Agonist and antagonist effects of apomorphine enantiomers on 5-HT3 receptors. van Hooft, J.A., Vijverberg, H.P. Neuropharmacology (1998)
- An ethological study of the effects of buspirone and the 5-HT3 receptor antagonist, BRL 43694 (granisetron) on behaviour during social interactions in female and male mice. Cutler, M.G. Neuropharmacology (1991)
- Cloning and functional expression of an apparent splice variant of the murine 5-HT3 receptor A subunit. Hope, A.G., Downie, D.L., Sutherland, L., Lambert, J.J., Peters, J.A., Burchell, B. Eur. J. Pharmacol. (1993)
- Expression of a serotonin-gated ion channel in embryonic neural and nonneural tissues. Tecott, L., Shtrom, S., Julius, D. Mol. Cell. Neurosci. (1995)
- Pharmacological characterization of 5-hydroxytryptamine3 receptors in murine brain and ileum using the novel radioligand [3H]RS-42358-197: evidence for receptor heterogeneity. Bonhaus, D.W., Wong, E.H., Stefanich, E., Kunysz, E.A., Eglen, R.M. J. Neurochem. (1993)
- Organization of the mouse 5-HT3 receptor gene and functional expression of two splice variants. Werner, P., Kawashima, E., Reid, J., Hussy, N., Lundström, K., Buell, G., Humbert, Y., Jones, K.A. Brain Res. Mol. Brain Res. (1994)
- Uropathic observations in mice expressing a constitutively active point mutation in the 5-HT3A receptor subunit. Bhattacharya, A., Dang, H., Zhu, Q.M., Schnegelsberg, B., Rozengurt, N., Cain, G., Prantil, R., Vorp, D.A., Guy, N., Julius, D., Ford, A.P., Lester, H.A., Cockayne, D.A. J. Neurosci. (2004)
- The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. Zeitz, K.P., Guy, N., Malmberg, A.B., Dirajlal, S., Martin, W.J., Sun, L., Bonhaus, D.W., Stucky, C.L., Julius, D., Basbaum, A.I. J. Neurosci. (2002)
- S-(+)-fenfluramine-induced nociceptive behavior in mice: Involvement of interactions between spinal serotonin and substance P systems. Tan-No, K., Takahashi, K., Shimoda, M., Sugawara, M., Nakagawasai, O., Niijima, F., Sato, T., Satoh, S., Tadano, T. Neuropeptides (2007)
- Structural features of the ligand-binding domain of the serotonin 5HT3 receptor. Yan, D., Schulte, M.K., Bloom, K.E., White, M.M. J. Biol. Chem. (1999)
- Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel. Lummis, S.C., Beene, D.L., Lee, L.W., Lester, H.A., Broadhurst, R.W., Dougherty, D.A. Nature (2005)
- Ion permeation through 5-hydroxytryptamine-gated channels in neuroblastoma N18 cells. Yang, J. J. Gen. Physiol. (1990)
- Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives. Cappelli, A., Anzini, M., Vomero, S., Mennuni, L., Makovec, F., Doucet, E., Hamon, M., Bruni, G., Romeo, M.R., Menziani, M.C., De Benedetti, P.G., Langer, T. J. Med. Chem. (1998)
- Agonist and antagonist effects of histamine H3 receptor ligands on 5-HT3 receptor-mediated ion currents in NG108-15 cells. Allen, M.C. Eur. J. Pharmacol. (1998)
- Ifenprodil influences changes in mouse behaviour related to acute and chronic ethanol administration. Malinowska, B., Napiórkowska-Pawlak, D., Pawlak, R., Buczko, W., Göthert, M. Eur. J. Pharmacol. (1999)
- Characteristics of [14C]guanidinium accumulation in NG 108-15 cells exposed to serotonin 5-HT3 receptor ligands and substance P. Emerit, M.B., Riad, M., Fattaccini, C.M., Hamon, M. J. Neurochem. (1993)
- 5-HT3 receptor antagonism by anpirtoline, a mixed 5-HT1 receptor agonist/5-HT3 receptor antagonist. Göthert, M., Hamon, M., Barann, M., Bönisch, H., Gozlan, H., Laguzzi, R., Metzenauer, P., Nickel, B., Szelenyi, I. Br. J. Pharmacol. (1995)
- Coexpression of the cannabinoid receptor type 1 with dopamine and serotonin receptors in distinct neuronal subpopulations of the adult mouse forebrain. Hermann, H., Marsicano, G., Lutz, B. Neuroscience (2002)
- Highly potent inhibitory effects of 5-HT3 receptor antagonist, GR38032F, on non-opioid defeat analgesia in male mice. Rodgers, R.J., Shepherd, J.K., Randall, J.I. Neuropharmacology (1990)