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Chemical Compound Review:

Adodatad (2R,3S,4R,5R)-2-[[1-amino-8- (3...

Synonyms: AC1MIWEU, CHEMBL315995, CHEBI:240977, 118436-57-0, S-Adenosyl-1,12-diamino-3-thio-9-azadodecane

Pegg, A.E. et al., Pegg, A.E. et al., Woster, P.M. et al.

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High impact information on Adodatad

The effects of the potent spermine synthase inhibitor S-adenosyl-1,12-diamino-3-thio-9-azadodecane (AdoDatad) on polyamine biosynthesis have been studied in transformed mouse fibroblasts (SV 3T3 cells) and in mouse leukemia cells (L1210) [1].
Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase [2].
Although higher concentrations were required, BDAP was as effective an inhibitor of spermine synthesis as the mechanism-based inhibitor, S-adenosyl-1,12-diamino-3-thio-9-azadodecane (AdoDATAD), and produced similar decreases in spermine and increases in AdoMetDC [3].

References

Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells. Pegg, A.E., Wechter, R., Poulin, R., Woster, P.M., Coward, J.K. Biochemistry (1989) [Pubmed]
Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase. Woster, P.M., Black, A.Y., Duff, K.J., Coward, J.K., Pegg, A.E. J. Med. Chem. (1989) [Pubmed]
Effect of N-(n-butyl)-1,3-diaminopropane on polyamine metabolism, cell growth and sensitivity to chloroethylating agents. Pegg, A.E., Coward, J.K. Biochem. Pharmacol. (1993) [Pubmed]

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