Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1MIYYS (3S,5R,9R,10R,13R,17R)-3,14- dihydroxy-10...

Synonyms: 39219-57-3, 5beta-Ketodiol (ecdysone)

Meister, M.F. et al., Bollenbacher, W.E. et al.

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High impact information on 2,22,25-Trideoxyecdysone

Larval epidermis and fat body are also able to transform 2,22,25-trideoxyecdysone into ecdysone; Malpighian tubules and midgut hydroxylate the precursor at C-2 but are apparently unable to hydroxylate both at C-22 and C-25 [1].
A high specific activity tritiated ecdysone precursor, 2,22,25-trideoxyecdysone, was used to probe the capacity of various embryonic and larval tissues to perform the last 3 hydroxylation steps in ecdysone biosynthesis [1].
alpha-Ecdysone (2beta,3beta,14alpha,22R,25-pentahydroxy-5beta-cholest-7-en-6-one) has been identified as the metabolism product of 3beta,14alpha-dihydroxy-5beta-cholest-7-en-6-one in isolated prothoracic glands of the tobacco hornworm, Manduca sexta [2].

References

Conversion of a radiolabelled ecdysone precursor, 2,22,25-trideoxyecdysone, by embryonic and larval tissues of Locusta migratoria. Meister, M.F., Dimarcq, J.L., Kappler, C., Hetru, C., Lagueux, M., Lanot, R., Luu, B., Hoffmann, J.A. Mol. Cell. Endocrinol. (1985) [Pubmed]
In vitro metabolism of 3beta-hydroxy-, and 3beta,14alpha-dihydroxy-[3alpha-3H]-5beta-cholest-7-en-6-one by the prothoracic glands of Manduca sexta. Bollenbacher, W.E., Galbraith, M.N., Gilbert, L.I., Horn, D.H. Steroids (1977) [Pubmed]

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