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Disease relevance of Manduca


High impact information on Manduca

  • Steroid-dependent survival of identifiable neurons in cultured ganglia of the moth Manduca sexta [6].
  • After discovery of the corazonin receptor in Drosophila, we identified its ortholog in the moth, Manduca sexta, as a prelude to physiological studies [7].
  • Rapid biosynthesis of N-linolenoyl-L-glutamine, an elicitor of plant volatiles, by membrane-associated enzyme(s) in Manduca sexta [8].
  • We have isolated from the tobacco hornworm, Manduca sexta, a serine proteinase that activates proPO, and have cloned its cDNA [9].
  • This discovery of a Manduca sexta CRABP (msCRABP) demonstrates the presence of a CRABP in invertebrates [10].

Chemical compound and disease context of Manduca


Biological context of Manduca


Anatomical context of Manduca


Associations of Manduca with chemical compounds

  • L-Canavanine and protein synthesis in the tobacco hornworm Manduca sexta [24].
  • 125I-Labeled alpha-bungarotoxin has been used to determine the distribution of putative acetylcholine receptors in normal and chronically deafferented antennal lobes in the brain of the moth Manduca sexta [25].
  • In Manduca, accessory planta retractor (APR) motoneurons undergo dendritic loss at the end of larval life in response to a rise in 20-hydroxyecdysone (20E) [26].
  • The cells in the embryonic CNS of the tobacco hawkmoth, Manduca sexta, that synthesize a cardioacceleratory peptide 2 (CAP2)-like antigen were identified using immunohistochemical techniques [27].
  • The EGPs: the eclosion hormone and cyclic GMP-regulated phosphoproteins. I. Appearance and partial characterization in the CNS of Manduca sexta [28].

Gene context of Manduca

  • The structural similarity to a Manduca early gene and the expression similarities to Drosophila early genes suggest that the DHR3 gene may also belong to the early gene class [29].
  • The structure of the DHR3 protein is strikingly similar to that of the MHR3 protein (e.g., 97% amino acid identity for the DNA binding domains), another orphan receptor encoded by an ecdysone-inducible early gene of another insect, Manduca sexta [29].
  • In both Manduca and Drosophila, the broad (br) gene is expressed in the epidermis during the formation of the pupa, but not during adult differentiation [30].
  • Isolation and embryonic expression of an abdominal-A-like gene from the lepidopteran, Manduca sexta [31].
  • Sequence analysis and in situ hybridizations to tissue sections suggest that the Manduca gene encodes a lepidopteran homologue of the Drosophila Bithorax complex gene abdominal-A [31].

Analytical, diagnostic and therapeutic context of Manduca


  1. Role of domain II, loop 2 residues of Bacillus thuringiensis CryIAb delta-endotoxin in reversible and irreversible binding to Manduca sexta and Heliothis virescens. Rajamohan, F., Cotrill, J.A., Gould, F., Dean, D.H. J. Biol. Chem. (1996) [Pubmed]
  2. Immulectin-2, a lipopolysaccharide-specific lectin from an insect, Manduca sexta, is induced in response to gram-negative bacteria. Yu, X.Q., Kanost, M.R. J. Biol. Chem. (2000) [Pubmed]
  3. Mutagenesis of specificity and toxicity regions of a Bacillus thuringiensis protoxin gene. Aronson, A.I., Wu, D., Zhang, C. J. Bacteriol. (1995) [Pubmed]
  4. Histamine-immunoreactive neurons in the midbrain and suboesophageal ganglion of sphinx moth Manduca sexta. Homberg, U., Hildebrand, J.G. J. Comp. Neurol. (1991) [Pubmed]
  5. Pest-managing efficacy of trans-asarone isolated from Daucus carota L. seeds. Momin, R.A., Nair, M.G. J. Agric. Food Chem. (2002) [Pubmed]
  6. Steroid-dependent survival of identifiable neurons in cultured ganglia of the moth Manduca sexta. Bennett, K.L., Truman, J.W. Science (1985) [Pubmed]
  7. Corazonin receptor signaling in ecdysis initiation. Kim, Y.J., Spalovská-Valachová, I., Cho, K.H., Zitnanova, I., Park, Y., Adams, M.E., Zitnan, D. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  8. Rapid biosynthesis of N-linolenoyl-L-glutamine, an elicitor of plant volatiles, by membrane-associated enzyme(s) in Manduca sexta. Lait, C.G., Alborn, H.T., Teal, P.E., Tumlinson, J.H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  9. Pro-phenol oxidase activating proteinase from an insect, Manduca sexta: a bacteria-inducible protein similar to Drosophila easter. Jiang, H., Wang, Y., Kanost, M.R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  10. Molecular cloning and characterization of an invertebrate cellular retinoic acid binding protein. Mansfield, S.G., Cammer, S., Alexander, S.C., Muehleisen, D.P., Gray, R.S., Tropsha, A., Bollenbacher, W.E. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  11. Molecular cloning of an insect aminopeptidase N that serves as a receptor for Bacillus thuringiensis CryIA(c) toxin. Knight, P.J., Knowles, B.H., Ellar, D.J. J. Biol. Chem. (1995) [Pubmed]
  12. Role of Bacillus thuringiensis Cry1 delta endotoxin binding in determining potency during lepidopteran larval development. Gilliland, A., Chambers, C.E., Bone, E.J., Ellar, D.J. Appl. Environ. Microbiol. (2002) [Pubmed]
  13. Differential inhibition by Bacillus thuringiensis delta endotoxin of leucine and aspartic acid uptake into BBMV from midgut of Manduca sexta. Reuveni, M., Dunn, P.E. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  14. Analysis of the properties of Bacillus thuringiensis insecticidal toxins using a potential-sensitive fluorescent probe. Kirouac, M., Vachon, V., Rivest, S., Schwartz, J.L., Laprade, R. J. Membr. Biol. (2003) [Pubmed]
  15. Proenzyme of Manduca sexta phenol oxidase: purification, activation, substrate specificity of the active enzyme, and molecular cloning. Hall, M., Scott, T., Sugumaran, M., Söderhäll, K., Law, J.H. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  16. Targeted ablation of CCAP neuropeptide-containing neurons of Drosophila causes specific defects in execution and circadian timing of ecdysis behavior. Park, J.H., Schroeder, A.J., Helfrich-Förster, C., Jackson, F.R., Ewer, J. Development (2003) [Pubmed]
  17. Sequencing and characterization of the ntp gene cluster for vacuolar-type Na(+)-translocating ATPase of Enterococcus hirae. Takase, K., Kakinuma, S., Yamato, I., Konishi, K., Igarashi, K., Kakinuma, Y. J. Biol. Chem. (1994) [Pubmed]
  18. Molecular cloning, developmental expression, and phosphorylation of ribosomal protein S6 in the endocrine gland responsible for insect molting. Song, Q., Gilbert, L.I. J. Biol. Chem. (1997) [Pubmed]
  19. Anti-immunoglobulin augments the B-cell antigen-presentation function independently of internalization of receptor-antigen complex. Casten, L.A., Lakey, E.K., Jelachich, M.L., Margoliash, E., Pierce, S.K. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  20. Isolation and molecular cloning of transferrin from the tobacco hornworm, Manduca sexta. Sequence similarity to the vertebrate transferrins. Bartfeld, N.S., Law, J.H. J. Biol. Chem. (1990) [Pubmed]
  21. Control of juvenile hormone biosynthesis. Evidence for phosphorylation of the 3-hydroxy-3-methylglutaryl coenzyme A reductase of insect corpus allatum. Monger, D.J., Law, J.H. J. Biol. Chem. (1982) [Pubmed]
  22. The B10.A mouse B cell response to pigeon cytochrome c is directed against the same area of the protein that is recognized by B10.A T cells in association with the Ek beta:Ek alpha Ia molecule. Hannum, C.H., Matis, L.A., Schwartz, R.H., Margoliash, E. J. Immunol. (1985) [Pubmed]
  23. A vacuolar-type proton pump energizes K+/H+ antiport in an animal plasma membrane. Wieczorek, H., Putzenlechner, M., Zeiske, W., Klein, U. J. Biol. Chem. (1991) [Pubmed]
  24. L-Canavanine and protein synthesis in the tobacco hornworm Manduca sexta. Rosenthal, G.A., Dahlman, D.L. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  25. Distribution of binding sites for 125I-labeled alpha-bungarotoxin in normal and deafferented antennal lobes of Manduca sexta. Hildebrand, J.G., Hall, L.M., Osmond, B.C. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  26. Thinking globally, acting locally: steroid hormone regulation of the dendritic architecture, synaptic connectivity and death of an individual neuron. Weeks, J.C. Prog. Neurobiol. (2003) [Pubmed]
  27. Immunological, biochemical and physiological analyses of cardioacceleratory peptide 2 (CAP2) activity in the embryo of the tobacco hawkmoth Manduca sexta. Broadie, K.S., Sylwester, A.W., Bate, M., Tublitz, N.J. Development (1990) [Pubmed]
  28. The EGPs: the eclosion hormone and cyclic GMP-regulated phosphoproteins. I. Appearance and partial characterization in the CNS of Manduca sexta. Morton, D.B., Truman, J.W. J. Neurosci. (1988) [Pubmed]
  29. DHR3: a Drosophila steroid receptor homolog. Koelle, M.R., Segraves, W.A., Hogness, D.S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  30. Broad specifies pupal development and mediates the 'status quo' action of juvenile hormone on the pupal-adult transformation in Drosophila and Manduca. Zhou, X., Riddiford, L.M. Development (2002) [Pubmed]
  31. Isolation and embryonic expression of an abdominal-A-like gene from the lepidopteran, Manduca sexta. Nagy, L.M., Booker, R., Riddiford, L.M. Development (1991) [Pubmed]
  32. Resolution of the V1 ATPase from Manduca sexta into subcomplexes and visualization of an ATPase-active A3B3EG complex by electron microscopy. Rizzo, V.F., Coskun, U., Radermacher, M., Ruiz, T., Armbruster, A., Gruber, G. J. Biol. Chem. (2003) [Pubmed]
  33. The receptor for Bacillus thuringiensis CrylA(c) delta-endotoxin in the brush border membrane of the lepidopteran Manduca sexta is aminopeptidase N. Knight, P.J., Crickmore, N., Ellar, D.J. Mol. Microbiol. (1994) [Pubmed]
  34. Enhancement by serotonin of the growth in vitro of antennal lobe neurons of the sphinx moth Manduca sexta. Mercer, A.R., Kirchhof, B.S., Hildebrand, J.G. J. Neurobiol. (1996) [Pubmed]
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