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Chemical Compound Review:

Sdpflrfamide (3S)-4-[(2S)-2-[[(1S)-1- [[(1S)-1-[[(1S)-1...

Synonyms: AC1MIZ2I, 110325-86-5, Ser-As-pro-phe-leu-arg-phe-amide

Santama, N. et al., Saunders, S.E. et al., Skingsley, D.R. et al., Bright, K. et al., Moulis, A., et al.

Moulis,

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High impact information on Sdpflrfamide

The FMRFamide gene of the snail Lymnaea encodes tetrapeptides (FMRFamide/FLRFamide) and heptapeptides (GDPFLRFamide/SDPFLRFamide) on separate exons [1].
Neuropeptides Gly-Asp-Pro-Phe-Leu-Arg-Phe-amide (GDPFLRFamide) and Ser-Asp-Pro-Phe-Leu-Arg-Phe-amide (SDPFLRFamide) are encoded by an exon 3' to Phe-Met-Arg-Phe-NH2 (FMRFamide) in the snail Lymnaea stagnalis [2].
This novel peptide, abundant in the snail brain (0.7 pmol per central nervous system), includes the N-terminal sequence SDPFFRF, which was previously considered to be a variant of the known heptapeptide SDPFLRFamide, also encoded within the same protein precursor [3].
A molecularly defined cardiorespiratory interneuron expressing SDPFLRFamide/GDPFLRFamide in the snail Lymnaea: monosynaptic connections and pharmacology [4].
The effects of some of the members of this superfamily (FMRFamide. FLRFamide, YMRFamide, TNRNFLRFamide, SDPFLRFamide, LMS) were examined [5].

Biological context of Sdpflrfamide

In Lymnaea, the FMRFamide and GDP/SDPFLRFamide neuropeptides are encoded by separate exons [6].

References

Mutually exclusive expression of alternatively spliced FMRFamide transcripts in identified neuronal systems of the snail Lymnaea. Bright, K., Kellett, E., Saunders, S.E., Brierley, M., Burke, J.F., Benjamin, P.R. J. Neurosci. (1993) [Pubmed]
Neuropeptides Gly-Asp-Pro-Phe-Leu-Arg-Phe-amide (GDPFLRFamide) and Ser-Asp-Pro-Phe-Leu-Arg-Phe-amide (SDPFLRFamide) are encoded by an exon 3' to Phe-Met-Arg-Phe-NH2 (FMRFamide) in the snail Lymnaea stagnalis. Saunders, S.E., Bright, K., Kellett, E., Benjamin, P.R., Burke, J.F. J. Neurosci. (1991) [Pubmed]
Post-translational processing of the alternative neuropeptide precursor encoded by the FMRFamide gene in the pulmonate snail Lymnaea stagnalis. Santama, N., Li, K.W., Geraerts, W.P., Benjamin, P.R., Burke, J.F. Eur. J. Neurosci. (1996) [Pubmed]
A molecularly defined cardiorespiratory interneuron expressing SDPFLRFamide/GDPFLRFamide in the snail Lymnaea: monosynaptic connections and pharmacology. Skingsley, D.R., Bright, K., Santama, N., van Minnen, J., Brierley, M.J., Burke, J.F., Benjamin, P.R. J. Neurophysiol. (1993) [Pubmed]
RFamide neuropeptide actions on the molluscan heart. Moulis, A. Acta. Biol. Hung. (2004) [Pubmed]
Cell-specific alternative RNA splicing of an FMRFamide gene transcript in the brain. Saunders, S.E., Kellett, E., Bright, K., Benjamin, P.R., Burke, J.F. J. Neurosci. (1992) [Pubmed]

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